| SCN4B inhibits the progression of lung adenocarcinoma and is associated with better prognosis. | SCN4B inhibits the progression of lung adenocarcinoma and is associated with better prognosis.
Ma M, Guo B, Lu H, Hong L., Free PMC Article | 12/23/2023 |
| The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells. | The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells.
Doray A, Lemoine R, Severin M, Chadet S, Lopez-Charcas O, Héraud A, Baron C, Besson P, Monteil A, Pedersen SF, Roger S., Free PMC Article | 10/30/2021 |
| Silencing of microRNA-3175 represses cell proliferation and invasion in prostate cancer by targeting the potential tumor-suppressor SCN4B. | Silencing of microRNA-3175 represses cell proliferation and invasion in prostate cancer by targeting the potential tumor-suppressor SCN4B.
Huang H, Qing XY, Zhou Q, Li HD, Hu ZY. | 10/30/2021 |
| These data suggest that rare variant p.Gly8Ser of SCN4B confers a significant risk of AF, and SCN4B is a candidate susceptibility gene for AF. | Significant association of rare variant p.Gly8Ser in cardiac sodium channel β4-subunit SCN4B with atrial fibrillation.
Xiong H, Yang Q, Zhang X, Wang P, Chen F, Liu Y, Wang P, Zhao Y, Li S, Huang Y, Chen S, Wang X, Zhang H, Yu D, Tan C, Fang C, Huang Y, Wu G, Wu Y, Cheng X, Liao Y, Zhang R, Yang Y, Ke T, Ren X, Li H, Tu X, Xia Y, Xu C, Chen Q, Wang QK., Free PMC Article | 05/9/2020 |
| Data identified one rare nonsynonymous heterozygous variant, p.Gly8Ser, in SCN4B that was significantly associated with a risk of ventricular tachycardia (VT) in two independent populations. | Identification of rare variants in cardiac sodium channel β4-subunit gene SCN4B associated with ventricular tachycardia.
Yang Q, Xiong H, Xu C, Huang Y, Tu X, Wu G, Fu F, Wang Z, Wang L, Zhao Y, Li S, Huang Y, Wang C, Wang D, Yao Y, Wang F, Wang Y, Xue Y, Wang P, Chen Q, Pu J, Wang QK., Free PMC Article | 08/3/2019 |
| this study reports the cryo-electron microscopy structure of the human Nav1.4-beta1 complex at 3.2-A resolution. | Structure of the human voltage-gated sodium channel Na(v)1.4 in complex with β1.
Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N. | 12/22/2018 |
| SCN4B overexpression reduces cancer cell invasiveness and tumour progression. | SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer.
Bon E, Driffort V, Gradek F, Martinez-Caceres C, Anchelin M, Pelegrin P, Cayuela ML, Marionneau-Lambot S, Oullier T, Guibon R, Fromont G, Gutierrez-Pajares JL, Domingo I, Piver E, Moreau A, Burlaud-Gaillard J, Frank PG, Chevalier S, Besson P, Roger S., Free PMC Article | 09/8/2018 |
| Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer. | Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer.
Gong Y, Yang J, Wu W, Liu F, Su A, Li Z, Zhu J, Wei T., Free PMC Article | 08/11/2018 |
| Data suggest that extracellular domains of SCN4B directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); SCN4B homodimers appear to play role in cell-cell adhesion. | Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion.
Shimizu H, Tosaki A, Ohsawa N, Ishizuka-Katsura Y, Shoji S, Miyazaki H, Oyama F, Terada T, Shirouzu M, Sekine SI, Nukina N, Yokoyama S., Free PMC Article | 08/26/2017 |
| The expression of a human-specific isoform of the voltage-gated sodium channel subunit SCN4B was significantly correlated to lifetime alcohol consumption | Transcriptome organization for chronic alcohol abuse in human brain.
Farris SP, Arasappan D, Hunicke-Smith S, Harris RA, Mayfield RD., Free PMC Article | 08/6/2016 |
| Contribution of Cardiac Sodium Channel beta-Subunit Variants to Brugada Syndrome. | Contribution of Cardiac Sodium Channel β-Subunit Variants to Brugada Syndrome.
Peeters U, Scornik F, Riuró H, Pérez G, Komurcu-Bayrak E, Van Malderen S, Pappaert G, Tarradas A, Pagans S, Daneels D, Breckpot K, Brugada P, Bonduelle M, Brugada R, Van Dooren S. | 07/16/2016 |
| Human Nav1.6 channels generate larger resurgent currents than human Nav1.1 channels, but the SCN4B-derived Navbeta4 peptide does not protect either isoform from use-dependent reduction. | Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.
Patel RR, Barbosa C, Xiao Y, Cummins TR., Free PMC Article | 04/30/2016 |
| In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes. | The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.
Winkel BG, Yuan L, Olesen MS, Sadjadieh G, Wang Y, Risgaard B, Jabbari R, Haunsø S, Holst AG, Hollegaard MV, Tfelt-Hansen J, Jespersen T. | 03/12/2016 |
| results suggest the presence of a docking site that is maintained by a cysteine bridge buried within the hydrophobic core of beta4. | Crystallographic insights into sodium-channel modulation by the β4 subunit.
Gilchrist J, Das S, Van Petegem F, Bosmans F., Free PMC Article | 03/1/2014 |
| this is the first study to demonstrate an association of SCN4B mutations with AF, suggesting SCN4B as a novel AF susceptibility gene. | Mutations of the SCN4B-encoded sodium channel β4 subunit in familial atrial fibrillation.
Li RG, Wang Q, Xu YJ, Zhang M, Qu XK, Liu X, Fang WY, Yang YQ. | 12/14/2013 |
| SCN5A-SCN4B were found to be essential for positive selection of CD4(+) T cells. | A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells.
Lo WL, Donermeyer DL, Allen PM., Free PMC Article | 10/27/2012 |
| The researchers found evidence of an association between SCN4B subunit mutations and sudden infant death syndrome pathogenesis. | Sudden infant death syndrome-associated mutations in the sodium channel beta subunits.
Tan BH, Pundi KN, Van Norstrand DW, Valdivia CR, Tester DJ, Medeiros-Domingo A, Makielski JC, Ackerman MJ, Tan BH, Pundi KN, Van Norstrand DW, Valdivia CR, Tester DJ, Medeiros-Domingo A, Makielski JC, Ackerman MJ., Free PMC Articles: PMC2909680, PMC2909680 | 06/18/2011 |
| The paroxysmal extreme pain disorder associated Nav1.7 missense mutations M1627K, T1464I and V1299F increase Navbeta4 peptide-mediated resurgent sodium currents, in contrast to the erythromelalgia associated I848T and L858H Nav1.7 missense mutations. | Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents.
Theile JW, Jarecki BW, Piekarz AD, Cummins TR., Free PMC Article | 05/28/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesMutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation.
Olesen MS, Jespersen T, Nielsen JB, Liang B, Møller DV, Hedley P, Christiansen M, Varró A, Olesen SP, Haunsø S, Schmitt N, Svendsen JH. Sudden infant death syndrome-associated mutations in the sodium channel beta subunits.
Tan BH, Pundi KN, Van Norstrand DW, Valdivia CR, Tester DJ, Medeiros-Domingo A, Makielski JC, Ackerman MJ, Tan BH, Pundi KN, Van Norstrand DW, Valdivia CR, Tester DJ, Medeiros-Domingo A, Makielski JC, Ackerman MJ. Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation.
Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM, Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM. | 12/2/2009 |
| Loss of function mutations in sodium channel beta-subunits were identified in patients with atrial fibrillation and were associated with a distinctive ECG phenotype | Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation.
Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM, Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM., Free PMC Articles: PMC2727725, PMC2727725 | 01/21/2010 |
| Co-expression of the beta1 subunit impeded slow inactivation elicited by a 30-s depolarization, such that the voltage dependence was right shifted (depolarized) and recovery was hastened. | Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit.
Webb J, Wu FF, Cannon SC., Free PMC Article | 01/21/2010 |
| molecular cloning and characterization of sodium channel beta4 | Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.
Yu FH, Westenbroek RE, Silos-Santiago I, McCormick KA, Lawson D, Ge P, Ferriera H, Lilly J, DiStefano PS, Catterall WA, Scheuer T, Curtis R., Free PMC Article | 01/21/2010 |
| SCN4B is a long QT syndrome susceptibility gene. | SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome.
Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ., Free PMC Article | 01/21/2010 |