| Aberrant inactivation of SCNN1G promotes the motility of head and neck squamous cell carcinoma. | Aberrant inactivation of SCNN1G promotes the motility of head and neck squamous cell carcinoma.
Yang Y, Zhong X, Lan Y, Liang P, Huang Y, Wang Y, Zhou X, Zhang Z, Liang Y, Xiao X. | 12/10/2022 |
| gammaENaC/CD9 in urinary extracellular vesicles as a potential biomarker of MR activity. | γENaC/CD9 in urinary extracellular vesicles as a potential biomarker of MR activity.
Hayakawa T, Fukuhara A, Saiki A, Otsuki M, Shimomura I. | 12/25/2021 |
| Pediatric Liddle Syndrome Caused by a Novel SCNN1G Variant in a Chinese Family and Characterized by Early-Onset Hypertension. | Pediatric Liddle Syndrome Caused by a Novel SCNN1G Variant in a Chinese Family and Characterized by Early-Onset Hypertension.
Fan P, Pan XC, Zhang D, Yang KQ, Zhang Y, Tian T, Luo F, Ma WJ, Liu YX, Wang LP, Zhang HM, Song L, Cai J, Zhou XL., Free PMC Article | 07/17/2021 |
| DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes. | DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes.
Pierandrei S, Truglio G, Ceci F, Del Porto P, Bruno SM, Castellani S, Conese M, Ascenzioni F, Lucarelli M., Free PMC Article | 05/15/2021 |
| Phosphatidylinositol 4,5-bisphosphate directly interacts with the beta and gamma subunits of the sodium channel ENaC. | Phosphatidylinositol 4,5-bisphosphate directly interacts with the β and γ subunits of the sodium channel ENaC.
Archer CR, Enslow BT, Carver CM, Stockand JD., Free PMC Article | 01/2/2021 |
| Liddle syndrome due to a novel mutation in the gamma subunit of the epithelial sodium channel (ENaC) in family from Russia: a case report. | Liddle syndrome due to a novel mutation in the γ subunit of the epithelial sodium channel (ENaC) in family from Russia: a case report.
Kozina AA, Trofimova TA, Okuneva EG, Baryshnikova NV, Obuhova VA, Krasnenko AY, Tsukanov KY, Klimchuk OI, Surkova EI, Shatalov PA, Ilinsky VV., Free PMC Article | 10/31/2020 |
| Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption. | Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption.
Nattramilarasu PK, Bücker R, Lobo de Sá FD, Fromm A, Nagel O, Lee IM, Butkevych E, Mousavi S, Genger C, Kløve S, Heimesaat MM, Bereswill S, Schweiger MR, Nielsen HL, Troeger H, Schulzke JD., Free PMC Article | 10/3/2020 |
| SCNN1G was not associated with Salt Sensitivity of Blood Pressure in rare variant analyses. | Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.
Gu X, Gu D, He J, Rao DC, Hixson JE, Chen J, Li J, Huang J, Wu X, Rice TK, Shimmin LC, Kelly TN., Free PMC Article | 11/9/2019 |
| Albuminuria in kidney transplant recipients is associated with hypertension, ability of urine to proteolytically activate ENaC current, and increased abundance of gammaENaC. | Albuminuria in kidney transplant recipients is associated with increased urinary serine proteases and activation of the epithelial sodium channel.
Hinrichs GR, Michelsen JS, Zachar R, Friis UG, Svenningsen P, Birn H, Bistrup C, Jensen BL. | 07/20/2019 |
| Proteolytic cleavage activates epithelial sodium channel (SCNN) by removal of specific segments in finger domains of alpha and gamma subunits. Data suggest that the lower "palm" domain of SCNN1A is essential for allosteric activation of the SCNN heterotetramer [SCNN1A(1)-SCNN1B-SCNN1A(2)-SCNN1G]. | Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel.
Shobair M, Popov KI, Dang YL, He H, Stutts MJ, Dokholyan NV., Free PMC Article | 01/16/2019 |
| In the present study, the SCNN1G gene was associated with 24-h urinary sodium excretion but was not related to blood pressure. The SCNN1A and SCNN1B genes were not associated with blood pressure either. | Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure.
Yang YJ, Kim J, Kwock CK., Free PMC Article | 11/3/2018 |
| The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells. | Derlin-1 promotes ubiquitylation and degradation of the epithelial Na(+) channel, ENaC.
You H, Ge Y, Zhang J, Cao Y, Xing J, Su D, Huang Y, Li M, Qu S, Sun F, Liang X. | 08/12/2017 |
| hENaC incorporating the Liddle-mutated beta-subunit lacks one or more PKC phosphorylation sites, thereby significantly reducing the inhibitory effect of PKC on Na(+) channel activity, whereas hENaC incorporating Liddle-mutated gamma-subunits remains as susceptible to PKC as wild-type hENaC. | Liddle-Mutation of the β-Subunit, but not the γ-Subunit, Attenuates Protein Kinase C-Mediated Inhibition of Human Epithelial Sodium Channels (hENaC).
Robins GG, Sandle GI., Free PMC Article | 07/29/2017 |
| deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP. | δβγ-ENaC is inhibited by CFTR but stimulated by cAMP in Xenopus laevis oocytes.
Rauh R, Hoerner C, Korbmacher C. | 06/24/2017 |
| One nonsynonymous amino acid variants in SCNN1G in nonwhite Cystic fibrosis patients with non-diagnostic CFTR genotypes was identified. | Assessment of epithelial sodium channel variants in nonwhite cystic fibrosis patients with non-diagnostic CFTR genotypes.
Brennan ML, Pique LM, Schrijver I. | 10/29/2016 |
| Both vascular smooth muscle cell and bronchial gamma-ENaC downregulation may explain pulmonary fluid disturbances and participate in pulmonary edema pathogenesis. | A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury.
Ampawong S, Chaisri U, Viriyavejakul P, Prapansilp P, Grau GE, Turner GD, Pongponratn E., Free PMC Article | 06/28/2016 |
| The transcriptional expression of alpha, beta, and gamma subunits of ENaC was elevated in nasal polyp compared to nasal mucosa | Expression and distribution of epithelial sodium channel in nasal polyp and nasal mucosa.
Jiang Y, Xu J, Chen Y, Shi J, Zhang C, Li J. | 05/28/2016 |
| Suggest that SCNN1G gene has important roles in blood pressure regulation in the Han Chinese population. | Associations of epithelial sodium channel genes with blood pressure: the GenSalt study.
Liu F, Yang X, Mo X, Huang J, Chen J, Kelly TN, Hixson JE, Rao DC, Gu CC, Shimmin LC, Chen J, Rice TK, Li J, Schwander K, He J, Liu DP, Gu D., Free PMC Article | 12/12/2015 |
| SCNN1A and SCNN1G SNPs may contribute to blood pressure changes over time in the Han Chinese population. | Associations of epithelial sodium channel genes with blood pressure changes and hypertension incidence: the GenSalt study.
Yang X, He J, Gu D, Hixson JE, Huang J, Rao DC, Shimmin LC, Chen J, Rice TK, Li J, Schwander K, Kelly TN., Free PMC Article | 06/20/2015 |
| Data indicate that urokinase-type plasminogen activator (uPA) activates epithelial sodium channel, gamma subunit (ENaC gamma) through catalytic activity-dependent proteolytic modification. | Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites.
Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA., Free PMC Article | 05/16/2015 |
| High serum leptin may reduce endometrial receptivity by activating the STAT3 signal pathway and down-regulating gamma-ENaC expression in the endometrium. | Leptin down-regulates γ-ENaC expression: a novel mechanism involved in low endometrial receptivity.
Lin XH, Liu ME, Xu HY, Chen XJ, Wang H, Tian S, Sheng JZ, Huang HF. | 04/18/2015 |
| human kidney gammaENaC is subject to proteolytic cleavage, yielding fragments compatible with furin cleavage, and proteinuria is associated with cleavage at the putative prostasin/kallikrein site and removal of the inhibitory tract within gammaENaC | The epithelial sodium channel γ-subunit is processed proteolytically in human kidney.
Zachar RM, Skjødt K, Marcussen N, Walter S, Toft A, Nielsen MR, Jensen BL, Svenningsen P., Free PMC Article | 03/21/2015 |
| gamma subunit palmitoylation has a dominant role over beta subunit palmitoylation in modulating ENaC gating | Cysteine palmitoylation of the γ subunit has a dominant role in modulating activity of the epithelial sodium channel.
Mukherjee A, Mueller GM, Kinlough CL, Sheng N, Wang Z, Mustafa SA, Kashlan OB, Kleyman TR, Hughey RP., Free PMC Article | 12/20/2014 |
| WNK4 inhibits ENaC channel activity independently of Nedd4-2-mediated ENaC ubiquitination. | WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.
Yu L, Cai H, Yue Q, Alli AA, Wang D, Al-Khalili O, Bao HF, Eaton DC., Free PMC Article | 09/7/2013 |
| found a diminished expression of the three subunits of the ENaC in the membranes of preeclamptic placentas in comparison with the normal ones | Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta.
Marino GI, Kotsias BA. | 09/7/2013 |