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    CCL2 C-C motif chemokine ligand 2 [ Homo sapiens (human) ]

    Gene ID: 6347, updated on 19-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.

    LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.
    Lin H, Fu L, Zhou X, Yu A, Chen Y, Liao W, Shu G, Zhang L, Tan L, Liang H, Wang Z, Deng Q, Wang J, Jin M, Chen Z, Wei J, Cao J, Chen W, Li X, Li P, Lu J, Luo J.

    09/5/2024
    Virus-Induced Host Chemokine CCL2 in COVID-19 Pathogenesis: Potential Prognostic Marker and Target of Anti-Inflammatory Strategy.

    Virus-Induced Host Chemokine CCL2 in COVID-19 Pathogenesis: Potential Prognostic Marker and Target of Anti-Inflammatory Strategy.
    Ansari AW, Ahmad F, Alam MA, Raheed T, Zaqout A, Al-Maslamani M, Ahmad A, Buddenkotte J, Al-Khal A, Steinhoff M.

    09/4/2024
    CCL2 mediated IKZF1 expression promotes M2 polarization of glioma-associated macrophages through CD84-SHP2 pathway.

    CCL2 mediated IKZF1 expression promotes M2 polarization of glioma-associated macrophages through CD84-SHP2 pathway.
    Song Y, Zhang Y, Wang Z, Lin Y, Cao X, Han X, Li G, Hou A, Han S.

    09/4/2024
    Epithelial cells derived exosomal miR-203a-3p facilitates stromal inflammation of type IIIA chronic prostatitis/chronic pelvic pain syndrome by targeting DUSP5 and increasing MCP-1 generation.

    Epithelial cells derived exosomal miR-203a-3p facilitates stromal inflammation of type IIIA chronic prostatitis/chronic pelvic pain syndrome by targeting DUSP5 and increasing MCP-1 generation.
    Song G, Zhao F, Ni R, Deng B, Chen S, Hu R, Zheng J, Peng Y, Liu H, Luo Y, Zhou Z, Huang G, Shen W., Free PMC Article

    06/11/2024
    Association of CC-chemokine ligand-2 gene polymorphisms with leprosy reactions.

    Association of CC-chemokine ligand-2 gene polymorphisms with leprosy reactions.
    Biswas SK, Mohanty KK, Singh V, Natrajan M, Arora M, Chakma JK, Tripathy SP.

    06/8/2024
    Association of MCP-1 promotor polymorphism with disease severity of Crimean-Congo hemorrhagic fever.

    Association of MCP-1 promotor polymorphism with disease severity of Crimean-Congo hemorrhagic fever.
    Bagci B, Bagci G, Buyuktuna SA, Elaldi N.

    06/5/2024
    Hypoxia-induced miR-210-3p expression in lung adenocarcinoma potentiates tumor development by regulating CCL2 mediated monocyte infiltration.

    Hypoxia-induced miR-210-3p expression in lung adenocarcinoma potentiates tumor development by regulating CCL2 mediated monocyte infiltration.
    Arora L, Patra D, Roy S, Nanda S, Singh N, Verma AK, Chakraborti A, Dasgupta S, Pal D., Free PMC Article

    05/9/2024
    MCP-1 controls IL-17-promoted monocyte migration and M1 polarization in osteoarthritis.

    MCP-1 controls IL-17-promoted monocyte migration and M1 polarization in osteoarthritis.
    Hsieh SL, Yang SY, Lin CY, He XY, Tsai CH, Fong YC, Lo YS, Tang CH.

    05/1/2024
    BRG1 mediates epigenetic regulation of TNFalpha-induced CCL2 expression in oral tongue squamous cell carcinoma cells.

    BRG1 mediates epigenetic regulation of TNFα-induced CCL2 expression in oral tongue squamous cell carcinoma cells.
    Xu M, Lu X, Zhu F, Sun X, Yao H, Zhang J, Chen W, Zhu H, Liu F, Shi SL, Deng X.

    04/17/2024
    Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling.

    Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling.
    Yamazaki S, Mabuchi Y, Kimura T, Suto EG, Hisamatsu D, Naraoka Y, Kondo A, Azuma Y, Kikuchi R, Nishikii H, Morishita S, Araki M, Komatsu N, Akazawa C., Free PMC Article

    03/21/2024
    CCL2 promotes metastasis and epithelial-mesenchymal transition of non-small cell lung cancer via PI3K/Akt/mTOR and autophagy pathways.

    CCL2 promotes metastasis and epithelial-mesenchymal transition of non-small cell lung cancer via PI3K/Akt/mTOR and autophagy pathways.
    Xu H, Wang J, Al-Nusaif M, Ma H, Le W., Free PMC Article

    03/13/2024
    MCP-1/CCR2 axis is involved in the regulation of gammadeltaT cells in lupus nephritis.

    MCP-1/CCR2 axis is involved in the regulation of γδT cells in lupus nephritis.
    Deng T, Lei F, Wang Z, Wang Y, Li G, Zhu Y, Du B, Xi X.

    03/6/2024
    Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway.

    Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway.
    Tian S, Chen X, Wu W, Lin H, Qing X, Liu S, Wang B, Xiao Y, Shao Z, Peng Y., Free PMC Article

    03/6/2024
    [Expression of MCP-1 and CCR2 in Newly Diagnosed Diffuse Large B-Cell Lymphoma and Clinical Significance].

    [Expression of MCP-1 and CCR2 in Newly Diagnosed Diffuse Large B-Cell Lymphoma and Clinical Significance].
    Wang M, Zhang PP, Zhu Q, Hu ZL, Bai X, Wu YP, Li JJ.

    02/27/2024
    Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study.

    Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study.
    Fang Y, Wang B, Pang B, Zhou Z, Xing Y, Pang P, Zheng D, Zhang G, Yang B., Free PMC Article

    02/15/2024
    FNDC4 reduces inflammation, proliferation, invasion and migration of rheumatoid synovial cells by inhibiting CCL2/ERK signaling.

    FNDC4 reduces inflammation, proliferation, invasion and migration of rheumatoid synovial cells by inhibiting CCL2/ERK signaling.
    Xiao C, Xie S, Ouyang S.

    02/8/2024
    Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 (MCP-1) and 28-Day Mortality in Elderly Patients with Sepsis: A Retrospective Single-Center Study.

    Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 (MCP-1) and 28-Day Mortality in Elderly Patients with Sepsis: A Retrospective Single-Center Study.
    Duan Y, Liu M, Wang J, Wei B., Free PMC Article

    01/9/2024
    CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung cancer (NSCLC).

    CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung cancer (NSCLC).
    Drosslerova M, Sterclova M, Taskova A, Hytych V, Richterova E, Bruzova M, Spunda M, Komarc M, Koziar Vasakova M.

    12/18/2023
    Association between the MCP-1 -2518 A > G (rs1024611) polymorphism and susceptibility to type 2 diabetes mellitus and diabetic nephropathy: a meta-analysis.

    Association between the MCP-1 -2518 A > G (rs1024611) polymorphism and susceptibility to type 2 diabetes mellitus and diabetic nephropathy: a meta-analysis.
    Chang WW, Zhang L, Wen LY, Tao YJ, Xiong JJ, Tong X, Jin YL, Su H., Free PMC Article

    12/6/2023
    Macrophage-Derived Factors with the Potential to Contribute to Pathogenicity of HIV-1 and HIV-2: Role of CCL-2/MCP-1.

    Macrophage-Derived Factors with the Potential to Contribute to Pathogenicity of HIV-1 and HIV-2: Role of CCL-2/MCP-1.
    Gao C, Ouyang W, Kutza J, Grimm TA, Fields K, Lankford CSR, Schwartzkopff F, Paciga M, Stantchev T, Tiffany L, Strebel K, Clouse KA., Free PMC Article

    12/4/2023
    C5a enhances Vdelta1 T cells recruitment via the CCL2-CCR2 axis in IgA nephropathy.

    C5a enhances Vδ1 T cells recruitment via the CCL2-CCR2 axis in IgA nephropathy.
    Deng S, Zhou F, Wang F, Jiang Y, Tang J, Hu X, Luo L, Jin Y, Huang L, Sun D, Xiao G, Feng J, Li X.

    11/30/2023
    Prediction of spontaneous preterm birth using CCL2 and CXCL10 in maternal serum of symptomatic high-risk pregnant women: a prospective cohort study.

    Prediction of spontaneous preterm birth using CCL2 and CXCL10 in maternal serum of symptomatic high-risk pregnant women: a prospective cohort study.
    Hoffmann JA, Gründler K, Richter DU, Stubert J., Free PMC Article

    11/27/2023
    CCL2 is a key regulator and therapeutic target for periodontitis.

    CCL2 is a key regulator and therapeutic target for periodontitis.
    Jiang W, Xu T, Song Z, Wang X, Yuan S, Li Q, Wei Y, Wang C, Yang G, Cao J, Mo Y, Liu Z, Li N, Li S, Lv P, Zhang Y, Wang Y, Hu W.

    11/20/2023
    Serum cytokines MCP-1 and GCS-F as potential biomarkers in pediatric inflammatory bowel disease.

    Serum cytokines MCP-1 and GCS-F as potential biomarkers in pediatric inflammatory bowel disease.
    Ott A, Tutdibi E, Goedicke-Fritz S, Schöpe J, Zemlin M, Nourkami-Tutdibi N., Free PMC Article

    11/8/2023
    FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.

    FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
    Hu WM, Li M, Ning JZ, Tang YQ, Song TB, Li LZ, Zou F, Cheng F, Yu WM., Free PMC Article

    11/7/2023
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