| LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25. | LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25.
Li J, Muhammad J, Xie T, Sun J, Lei Y, Wei Z, Pan S, Qin H, Shao L, Jiang D, Zhang Q. | 12/25/2021 |
| CCL25 and CCR9 is a unique pathway that potentiates pannus formation by remodeling RA macrophages into mature osteoclasts. | CCL25 and CCR9 is a unique pathway that potentiates pannus formation by remodeling RA macrophages into mature osteoclasts.
Umar S, Palasiewicz K, Van Raemdonck K, Volin MV, Romay B, Ahmad I, Tetali C, Sweiss N, Amin MA, Zomorrodi RK, Shahrara S., Free PMC Article | 09/25/2021 |
| The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes. | The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes.
Atanes P, Lee V, Huang GC, Persaud SJ. | 12/26/2020 |
| Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9(+) T cells. | Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9(+) T cells.
Chen H, Cong X, Wu C, Wu X, Wang J, Mao K, Li J, Zhu G, Liu F, Meng X, Song J, Sun X, Wang X, Liu S, Zhang S, Yang X, Song Y, Yang YG, Sun T., Free PMC Article | 11/21/2020 |
| Thymusexpressed chemokine secreted by breast cancer cells promotes metastasis and inhibits apoptosis. | Thymus‑expressed chemokine secreted by breast cancer cells promotes metastasis and inhibits apoptosis.
Chen L, Zhang S, Shen Y, Qi L, Zhang Z, Tian H, Zou Z., Free PMC Article | 11/21/2020 |
| this study shows increased expression of CCL25 in chronic Rhinosinusitis with Nasal Polyps | Increased Expressions and Roles of CC Chemokine Ligand 21 and CC Chemokine Ligand 25 in Chronic Rhinosinusitis with Nasal Polyps.
Liu MZ, Chen SM, Xu Y, Kong YG, Deng YQ, Li F, Tao ZZ. | 05/16/2020 |
| CCL25 was able to induce proteoglycan and collagen type I production in anulus fibrosus-derived cells. | Chemokine CCL25 Induces Migration and Extracellular Matrix Production of Anulus Fibrosus-Derived Cells.
Stich S, Möller A, Cabraja M, Krüger JP, Hondke S, Endres M, Ringe J, Sittinger M., Free PMC Article | 11/17/2018 |
| It plays a pathogenic role in liver diseases and it will be a therapeutic target of the diseases. | [Role of inflammatory macrophages and CCR9/CCL25 chemokine axis in the pathogenesis of liver injury as a therapeutic target].
Nakamoto N. | 03/25/2017 |
| TECK was shown to be expressed by osteoblasts, and its receptor, CCR9, by osteoclast precursors. TECK increased P. gingivalis LPS-induced osteoclast numbers in an in vitro osteoclast formation assay using osteoclast precursors. T | Thymus-expressed chemokine enhances Porphyromonas gingivalis LPS-induced osteoclast formation via NFATc1 activation.
Usui M, Okamatsu Y, Sato T, Hanatani T, Moritani Y, Sano K, Yamamoto M, Nakashima K. | 02/18/2017 |
| that CCL25/CCR9 signal may provide cancer cells with chemotactic abilities through influencing several epithelial-mesenchymal transitionmarkers | CCL25/CCR9 Signal Promotes Migration and Invasion in Hepatocellular and Breast Cancer Cell Lines.
Zhang Z, Sun T, Chen Y, Gong S, Sun X, Zou F, Peng R. | 02/4/2017 |
| CCR9/CCL25 interactions are not only involved in colitis pathogenesis but also correlate with colonic inflammatory burden; further supporting the existence of overlapping mucosal lymphocyte recruitment pathways between the inflamed colon and liver. | Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity.
Trivedi PJ, Bruns T, Ward S, Mai M, Schmidt C, Hirschfield GM, Weston CJ, Adams DH., Free PMC Article | 12/17/2016 |
| CpG methylation is reduced in gingival biopsies of patients with periodontitis | Epigenetic characteristics in inflammatory candidate genes in aggressive periodontitis.
Schulz S, Immel UD, Just L, Schaller HG, Gläser C, Reichert S. | 11/12/2016 |
| Studies indicate important roles played by chemokine ligand 25 (CCL25)/chemokine receptor 9 (CCR9) in tumorigenesis, tumor chemoresistance and metastasis. | CCR9 in cancer: oncogenic role and therapeutic targeting.
Tu Z, Xiao R, Xiong J, Tembo KM, Deng X, Xiong M, Liu P, Wang M, Zhang Q., Free PMC Article | 10/29/2016 |
| CCL25 mRNA and protein levels were significantly increased in the nasopharyngeal carcinoma group compared with the control group. | Intracellular expression profile and clinical significance of the CCR9-CCL25 chemokine receptor complex in nasopharyngeal carcinoma.
Ye LF, Huang J, Zhang LP, Chen Z. | 05/7/2016 |
| CCR9-CCL25 interaction promoted proliferation and suppressed apoptosis of non-small cell lung cancer cells by activating the PI3K/Akt pathway. | CCR9-CCL25 interaction suppresses apoptosis of lung cancer cells by activating the PI3K/Akt pathway.
Li B, Wang Z, Zhong Y, Lan J, Li X, Lin H. | 03/19/2016 |
| High CCL25 expression is associated with the pathogenesis of ulcerative colitis. | CCL25/CCR9 interactions regulate the function of iNKT cells in oxazolone-induced colitis in mice.
Zhu S, Bing Y, Wang X, Yu Q, Wang Y, Xu S, Song L, Wang X, Xia B, Zhu Y, Zhou R., Free PMC Article | 10/31/2015 |
| Expression of CCR9 and CCL25, the only natural ligand of CCR9, was significantly higher (p<0.0001) in NSCLC tissues and serum respectively, compared to their respective controls. | CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis.
Gupta P, Sharma PK, Mir H, Singh R, Singh N, Kloecker GH, Lillard JW Jr, Singh S., Free PMC Article | 08/8/2015 |
| TECK derived from endometrial stromal cell and macrophages upregulates the number and function of Tregs in the ectopic milieu. | CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions.
Li MQ, Wang Y, Chang KK, Meng YH, Liu LB, Mei J, Wang Y, Wang XQ, Jin LP, Li DJ., Free PMC Article | 07/25/2015 |
| CCL25 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus. | Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J, Oppenheim JJ. | 09/10/2014 |
| CCL25 and CCR9 regulate colorectal cancer progression and invasion. | Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis.
Chen HJ, Edwards R, Tucci S, Bu P, Milsom J, Lee S, Edelmann W, Gümüs ZH, Shen X, Lipkin S., Free PMC Article | 11/24/2012 |
| cell migration assays revealed that mesenchymal stromal cells (MSCs) have tropism toward multiple myeloma (MM) cells, and CCL25 was identified as a major MM cell-produced chemoattractant for MSCs. | Bone marrow-derived mesenchymal stromal cells are attracted by multiple myeloma cell-produced chemokine CCL25 and favor myeloma cell growth in vitro and in vivo.
Xu S, Menu E, De Becker A, Van Camp B, Vanderkerken K, Van Riet I. | 05/26/2012 |
| We provide the first evidence that CCR9 and its natural ligand CCL25 are highly expressed by ovarian cancer tissue and their expression correlates with histological subtypes. | Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer.
Singh R, Stockard CR, Grizzle WE, Lillard JW Jr, Singh S., Free PMC Article | 10/8/2011 |
| CCL25 enhanced the expression of MMP-1, -9, -11 and -13 active proteins by BrCa cells in a CCR9-dependent fashion. | CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion.
Johnson-Holiday C, Singh R, Johnson E, Singh S, Stockard CR, Grizzle WE, Lillard JW Jr., Free PMC Article | 08/6/2011 |
| CCL25 may be involved in the differentiation of monocytes to macrophages particularly in rheumatoid arthritis | Monocytes/macrophages express chemokine receptor CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation.
Schmutz C, Cartwright A, Williams H, Haworth O, Williams JH, Filer A, Salmon M, Buckley CD, Middleton J., Free PMC Article | 01/22/2011 |
| over-expressed TECK interacts with CCR9 on the endometrial stromal cells in the endometriotic milieu, which may contribute to the onset and progression of endometriosis. | Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells.
Wang Y, Yu J, Luo X, Wang X, Li M, Wang L, Li D., Free PMC Article | 03/15/2010 |