| CXCL6: A potential therapeutic target for inflammation and cancer. | CXCL6: A potential therapeutic target for inflammation and cancer.
Dai CL, Yang HX, Liu QP, Rahman K, Zhang H. | 12/22/2023 |
| circ_0006089 Facilitates Gastric Cancer Progression via Decoying miR- 515-5p and Up-regulating CXCL6. | circ_0006089 Facilitates Gastric Cancer Progression via Decoying miR- 515-5p and Up-regulating CXCL6.
Guo Q, Ding X, Lv F, Wang A, Wang J. | 06/2/2023 |
| CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation. | CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation.
Wang X, Dai Y, Zhang X, Pan K, Deng Y, Wang J, Xu T., Free PMC Article | 12/4/2021 |
| CXCL6 fuels the growth and metastases of esophageal squamous cell carcinoma cells both in vitro and in vivo through upregulation of PD-L1 via activation of STAT3 pathway. | CXCL6 fuels the growth and metastases of esophageal squamous cell carcinoma cells both in vitro and in vivo through upregulation of PD-L1 via activation of STAT3 pathway.
Zheng S, Shen T, Liu Q, Liu T, Tuerxun A, Zhang Q, Yang L, Han X, Lu X. | 10/9/2021 |
| Hypoxia-CXCL6 axis affects arteriolar niche remodeling in acute myeloid leukemia. | Hypoxia-CXCL6 axis affects arteriolar niche remodeling in acute myeloid leukemia.
Li L, Man J, Zhao L., Free PMC Article | 04/24/2021 |
| Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting C-X-C Motif Chemokine Ligand 6. | Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting C-X-C Motif Chemokine Ligand 6.
Wang SZ, Zhang YL, Shi HB. | 03/28/2021 |
| Diagnostic value of GCP-2/CXCL-6 and hs-CRP in the diagnosis of acute appendicitis.", trans "Akut apandisit tanisinda GCP-2/CXCL-6 ve hs-CRP'nin tanisal degeri. | Diagnostic value of GCP-2/CXCL-6 and hs-CRP in the diagnosis of acute appendicitis.
Yücel Ç, Fırat Oğuz E, Er S, Balamir İ, Turhan T, Tez M. | 10/31/2020 |
| High CXCL6 expression in the wound exudate is associated with rapid wound healing of diabetic foot ulcers. | Wound exudate CXCL6: a potential biomarker for wound healing of diabetic foot ulcers.
Wang X, Li J, Wang Z, Deng A. | 01/11/2020 |
| our results reveal that CXCL6 plays an important role in liver fibrosis through stimulating the release of TGF-beta by Kupffer cells and thereby activating hepatic stellate cell. | CXCL6-EGFR-induced Kupffer cells secrete TGF-β1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C-MYC/EZH2 pathway in liver fibrosis.
Cai X, Li Z, Zhang Q, Qu Y, Xu M, Wan X, Lu L., Free PMC Article | 11/23/2019 |
| The results suggest a notable angiogenic potential of cardiac progenitor cells and identify CXCL6 as an important paracrine factor for cardiac progenitor cells that signals mainly through CXCR2. | CXCL6 is an important paracrine factor in the pro-angiogenic human cardiac progenitor-like cell secretome.
Torán JL, Aguilar S, López JA, Torroja C, Quintana JA, Santiago C, Abad JL, Gomes-Alves P, Gonzalez A, Bernal JA, Jiménez-Borreguero LJ, Alves PM, R-Borlado L, Vázquez J, Bernad A., Free PMC Article | 07/20/2019 |
| CXCL6 could reduce the expression of miR-515-5p in NSCLC cells; MiR-515-5p acted as a tumor suppressor by targeting CXCL6 in non-small cell lung cancer cell cells. | CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5p.
Li J, Tang Z, Wang H, Wu W, Zhou F, Ke H, Lu W, Zhang S, Zhang Y, Yang S, Ni S, Huang J. | 08/11/2018 |
| Study has provided the first report of fibroblast-derived CXCL12 enhancement of CXCL6 secretion in colon cancer cells, and of both CXCL12 and CXCL6 co-operatively regulating metastasis through the PI3K/Akt/mTOR signaling pathway. | Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer.
Ma JC, Sun XW, Su H, Chen Q, Guo TK, Li Y, Chen XC, Guo J, Gong ZQ, Zhao XD, Qi JB., Free PMC Article | 05/12/2018 |
| CXCL6 expression is upregulated by Fli1 deficiency in fibroblasts and endothelial cells, potentially contributing to the development of fibrosis and vasculopathy in the skin, lung, and heart of systemic sclerosis. | Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis.
Taniguchi T, Asano Y, Nakamura K, Yamashita T, Saigusa R, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sato S. | 05/5/2018 |
| There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1, CCL20, CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase inhibitors | Gene expression profile of renal cell carcinomas after neoadjuvant treatment with sunitinib: new pathways revealed.
Dzik C, Reis ST, Viana NI, Brito G, Paloppi I, Nahas W, Srougi M, Leite KRM. | 02/24/2018 |
| CXCL6 level is high in the serum of chronic hepatitis B patients.CXCL6 promotes human hepatocyte proliferation through the CXCR1-NFkappaB pathway and inhibits collagen I secretion by hepatic stellate cells. | CXCL6 promotes human hepatocyte proliferation through the CXCR1-NFκB pathway and inhibits collagen I secretion by hepatic stellate cells.
Li Z, Zhang Q, Zhang Q, Xu M, Qu Y, Cai X, Lu L. | 06/24/2017 |
| The role of PITX2 in glaucoma may be mediated partly by regulating the expression of CXCL6 and BBS5 and thus affecting immune functions and intraocular pressure. | Expression of CXCL6 and BBS5 that may be glaucoma relevant genes is regulated by PITX2.
Moazzeni H, Akbari MT, Yazdani S, Elahi E. | 01/28/2017 |
| This is the first study to note that elevated systemic CCL5 and CXCL6 were associated with moderate/severe lumbar disc degeneration. These chemokines may be systemic biomarkers for the diagnosis and monitoring of disc degeneration. | Systemic blood plasma CCL5 and CXCL6: Potential biomarkers for human lumbar disc degeneration.
Grad S, Bow C, Karppinen J, Luk KD, Cheung KM, Alini M, Samartzis D. | 10/22/2016 |
| The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA. | The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA.
Jovic S, Linge HM, Shikhagaie MM, Olin AI, Lannefors L, Erjefält JS, Mörgelin M, Egesten A. | 10/1/2016 |
| HIF-1alpha promotes HCC progression and metastasis by upregulating CXCL6 transcription in HCC cells. | HIF-1α plays a role in the chemotactic migration of hepatocarcinoma cells through the modulation of CXCL6 expression.
Tian H, Huang P, Zhao Z, Tang W, Xia J. | 08/15/2015 |
| Expression of the CXCL8, CXCL6 and CXCL1 genes are under the primary control of 1,25-dihydroxyvitamin D3 and its receptor. | Primary 1,25-dihydroxyvitamin D3 response of the interleukin 8 gene cluster in human monocyte- and macrophage-like cells.
Ryynänen J, Carlberg C., Free PMC Article | 06/28/2014 |
| Data suggest that expression of CXCL6 in trophoblasts is up-regulated during pregnancy development/placentation; CXCL6 expression inhibits trophoblast cell migration and invasion by down-regulating activity of MMP2 (matrix metalloproteinase 2). | The chemokine CXCL6 restricts human trophoblast cell migration and invasion by suppressing MMP-2 activity in the first trimester.
Zhang H, Hou L, Li CM, Zhang WY. | 03/22/2014 |
| Overexpression of GCP-2 in mesenchymal stem cells has the potential to enhance their angiogenic and survival properties. | Mesenchymal stem cells overexpressing GCP-2 improve heart function through enhanced angiogenic properties in a myocardial infarction model.
Kim SW, Lee DW, Yu LH, Zhang HZ, Kim CE, Kim JM, Park TH, Cha KS, Seo SY, Roh MS, Lee KC, Jung JS, Kim MH. | 01/12/2013 |
| Studies show that functional blocking of GCP-2 inhibits tumor growth and metastases. | Isotypic neutralizing antibodies against mouse GCP-2/CXCL6 inhibit melanoma growth and metastasis.
Verbeke H, Struyf S, Berghmans N, Van Coillie E, Opdenakker G, Uyttenhove C, Van Snick J, Van Damme J. | 04/23/2011 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)., Free PMC Article | 09/15/2010 |
| The aim of this study was to investigate the role of the transcription factors, AP-1 and NF-kappaB, in IL-6 and CXCL8 regulation in Jurkat T-cells. | Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells.
Khalaf H, Jass J, Olsson PE., Free PMC Article | 09/13/2010 |