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    PIEZO2 piezo type mechanosensitive ion channel component 2 [ Homo sapiens (human) ]

    Gene ID: 63895, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Mechanisms of mechanotransduction and physiological roles of PIEZO channels.

    Mechanisms of mechanotransduction and physiological roles of PIEZO channels.
    Xiao B.

    10/31/2024
    TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction.

    TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction.
    Zhang X, Shao J, Wang C, Liu C, Hao H, Li X, An Y, He J, Zhao W, Zhao Y, Kong Y, Jia Z, Wan S, Yuan Y, Zhang H, Zhang H, Du X.

    04/30/2024
    Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.

    Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.
    Gaite JJ, Solé-Magdalena A, García-Mesa Y, Cuendias P, Martin-Cruces J, García-Suárez O, Cobo T, Vega JA, Martín-Biedma B.

    04/16/2024
    PIEZO2 expression is an independent biomarker prognostic for gastric cancer and represents a potential therapeutic target.

    PIEZO2 expression is an independent biomarker prognostic for gastric cancer and represents a potential therapeutic target.
    Zhang YC, Yang M, Lu CD, Li QY, Shi JN, Shi J., Free PMC Article

    02/6/2024
    Asymmetric expression of PIEZO2 in paraspinal muscles of adolescent idiopathic scoliosis.

    Asymmetric expression of PIEZO2 in paraspinal muscles of adolescent idiopathic scoliosis.
    You X, Wu D, Chen A, Zhou X, Fan H, Jiang Y.

    01/17/2024
    Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics.

    Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics.
    Raha A, Wu Y, Zhong L, Raveenthiran J, Hong M, Taiyab A, Wang L, Wang B, Geng F., Free PMC Article

    01/3/2024
    Disrupted Neural Regeneration in Dry Eye Secondary to Ankylosing Spondylitis-With a Theoretical Link between Piezo2 Channelopathy and Gateway Reflex, WDR Neurons, and Flare-Ups.

    Disrupted Neural Regeneration in Dry Eye Secondary to Ankylosing Spondylitis-With a Theoretical Link between Piezo2 Channelopathy and Gateway Reflex, WDR Neurons, and Flare-Ups.
    Sonkodi B, Marsovszky L, Csorba A, Balog A, Kopper B, Keller-Pintér A, Nagy ZZ, Resch MD., Free PMC Article

    11/1/2023
    PIEZO2 and perineal mechanosensation are essential for sexual function.

    PIEZO2 and perineal mechanosensation are essential for sexual function.
    Lam RM, von Buchholtz LJ, Falgairolle M, Osborne J, Frangos E, Servin-Vences MR, Nagel M, Nguyen MQ, Jayabalan M, Saade D, Patapoutian A, Bönnemann CG, Ryba NJP, Chesler AT., Free PMC Article

    08/28/2023
    Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.

    Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.
    Obeidat AM, Wood MJ, Adamczyk NS, Ishihara S, Li J, Wang L, Ren D, Bennett DA, Miller RJ, Malfait AM, Miller RE., Free PMC Article

    08/25/2023
    PIEZO2 in somatosensory neurons controls gastrointestinal transit.

    PIEZO2 in somatosensory neurons controls gastrointestinal transit.
    Servin-Vences MR, Lam RM, Koolen A, Wang Y, Saade DN, Loud M, Kacmaz H, Frausto S, Zhang Y, Beyder A, Marshall KL, Bönnemann CG, Chesler AT, Patapoutian A., Free PMC Article

    08/9/2023
    PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.

    PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
    Shang H, Xu A, Yan H, Xu D, Zhang J, Fang X.

    07/27/2023
    PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2.

    PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2.
    Schaefer I, Verkest C, Vespermann L, Mair T, Voß H, Zeitzschel N, Lechner SG., Free PMC Article

    07/13/2023
    The role of PIEZO ion channels in the musculoskeletal system.

    The role of PIEZO ion channels in the musculoskeletal system.
    Savadipour A, Palmer D, Ely EV, Collins KH, Garcia-Castorena JM, Harissa Z, Kim YS, Oestrich A, Qu F, Rashidi N, Guilak F., Free PMC Article

    03/22/2023
    Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension.

    Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension.
    Tian S, Cai Z, Sen P, van Uden D, van de Kamp E, Thuillet R, Tu L, Guignabert C, Boomars K, Van der Heiden K, Brandt MM, Merkus D.

    01/28/2023
    Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy.

    Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy.
    Sonkodi B, Resch MD, Hortobágyi T., Free PMC Article

    08/20/2022
    Distal Arthrogryposis type 5 in an Italian family due to an autosomal dominant gain-of-function mutation of the PIEZO2 gene.

    Distal Arthrogryposis type 5 in an Italian family due to an autosomal dominant gain-of-function mutation of the PIEZO2 gene.
    Serra G, Antona V, Cannata C, Giuffrè M, Piro E, Schierz IAM, Corsello G., Free PMC Article

    08/6/2022
    PIEZO2 ion channels in proprioception.

    PIEZO2 ion channels in proprioception.
    Nagel M, Chesler AT.

    07/30/2022
    Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes.

    Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes.
    Kloth B, Mearini G, Weinberger F, Stenzig J, Geertz B, Starbatty J, Lindner D, Schumacher U, Reichenspurner H, Eschenhagen T, Hirt MN., Free PMC Article

    05/28/2022
    The Form and Function of PIEZO2.

    The Form and Function of PIEZO2.
    Szczot M, Nickolls AR, Lam RM, Chesler AT., Free PMC Article

    01/29/2022
    Molecular Sensors of Temperature, Pressure, and Pain with Special Focus on TRPV1, TRPM8, and PIEZO2 Ion Channels.

    Molecular Sensors of Temperature, Pressure, and Pain with Special Focus on TRPV1, TRPM8, and PIEZO2 Ion Channels.
    Ji RR, Lee SY., Free PMC Article

    12/25/2021
    Piezo2 downregulation via the Cre-lox system affects aqueous humor dynamics in mice.

    Piezo2 downregulation via the Cre-lox system affects aqueous humor dynamics in mice.
    Fang J, Hou F, Wu S, Liu Y, Wang L, Zhang J, Wang N, Wang K, Zhu W., Free PMC Article

    12/11/2021
    Glans clitoris innervation: PIEZO2 and sexual mechanosensitivity.

    Glans clitoris innervation: PIEZO2 and sexual mechanosensitivity.
    García-Mesa Y, Cárcaba L, Coronado C, Cobo R, Martín-Cruces J, García-Piqueras J, Feito J, García-Suárez O, Vega JA., Free PMC Article

    08/14/2021
    Confirming the involvement of PIEZO2 in the etiology of Marden-Walker syndrome.

    Confirming the involvement of PIEZO2 in the etiology of Marden-Walker syndrome.
    Seidahmed MZ, Maddirevula S, Miqdad AM, Al Faifi A, Al Samadi A, Alkuraya FS.

    07/24/2021
    PIEZO2 in sensory neurons and urothelial cells coordinates urination.

    PIEZO2 in sensory neurons and urothelial cells coordinates urination.
    Marshall KL, Saade D, Ghitani N, Coombs AM, Szczot M, Keller J, Ogata T, Daou I, Stowers LT, Bönnemann CG, Chesler AT, Patapoutian A., Free PMC Article

    02/6/2021
    The Piezo2 ion channel is mechanically activated by low-threshold positive pressure.

    The Piezo2 ion channel is mechanically activated by low-threshold positive pressure.
    Shin KC, Park HJ, Kim JG, Lee IH, Cho H, Park C, Sung TS, Koh SD, Park SW, Bae YM., Free PMC Article

    10/10/2020
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