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    SDHB succinate dehydrogenase complex iron sulfur subunit B [ Homo sapiens (human) ]

    Gene ID: 6390, updated on 13-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement.

    Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement.
    Taïeb D, Nölting S, Perrier ND, Fassnacht M, Carrasquillo JA, Grossman AB, Clifton-Bligh R, Wanna GB, Schwam ZG, Amar L, Bourdeau I, Casey RT, Crona J, Deal CL, Del Rivero J, Duh QY, Eisenhofer G, Fojo T, Ghayee HK, Gimenez-Roqueplo AP, Gill AJ, Hicks R, Imperiale A, Jha A, Kerstens MN, de Krijger RR, Lacroix A, Lazurova I, Lin FI, Lussey-Lepoutre C, Maher ER, Mete O, Naruse M, Nilubol N, Robledo M, Sebag F, Shah NS, Tanabe A, Thompson GB, Timmers HJLM, Widimsky J, Young WJ Jr, Meuter L, Lenders JWM, Pacak K.

    02/22/2024
    High rates of the SDHB p.Arg46Gln pathogenic variant predisposes New Zealand Maori to phaeochromocytoma/paraganglioma.

    High rates of the SDHB p.Arg46Gln pathogenic variant predisposes New Zealand Māori to phaeochromocytoma/paraganglioma.
    Shand JAD, van Schalkwyk J, Beavis V, Niyagama A, Taylor S, Eagleton C.

    10/23/2023
    Evidence for a Founder Effect of SDHB Exon 1 Deletion in Brazilian Patients With Paraganglioma.

    Evidence for a Founder Effect of SDHB Exon 1 Deletion in Brazilian Patients With Paraganglioma.
    Fagundes GFC, Freitas-Castro F, Santana LS, Afonso ACF, Petenuci J, Funari MFA, Guimaraes AG, Ledesma FL, Pereira MAA, Victor CR, Ferrari MSM, Coelho FMA, Srougi V, Tanno FY, Chambo JL, Latronico AC, Mendonca BB, Fragoso MCBV, Hoff AO, Almeida MQ.

    07/20/2023
    Distortion in transmission of pathogenic SDHB- and SDHD-mutated alleles from parent to offspring.

    Distortion in transmission of pathogenic SDHB- and SDHD-mutated alleles from parent to offspring.
    Davidoff DF, Lim ES, Benn DE, Subramaniam Y, Dorman E, Burgess JR, Akker SA, Clifton-Bligh RJ.

    04/12/2023
    Metabolic Characterization and Glyceraldehyde-3-Phosphate Dehydrogenase-Dependent Regulation of Epithelial Sodium Channels in hPheo1 Wild-type and SDHB Knockdown Cells.

    Metabolic Characterization and Glyceraldehyde-3-Phosphate Dehydrogenase-Dependent Regulation of Epithelial Sodium Channels in hPheo1 Wild-type and SDHB Knockdown Cells.
    Bala N, Yu L, Liu LP, Shelton L, Xu Y, Ghayee HK, Alli AA.

    02/28/2023
    SDHB variant type impacts phenotype and malignancy in pheochromocytoma-paraganglioma.

    SDHB variant type impacts phenotype and malignancy in pheochromocytoma-paraganglioma.
    Bayley JP, Bausch B, Jansen JC, Hensen EF, van der Tuin K, Corssmit EP, Devilee P, Neumann HP.

    01/7/2023
    Gastrointestinal stromal tumors caused by novel germline variants in SDHB and KIT: a report of two cases and literature review.

    Gastrointestinal stromal tumors caused by novel germline variants in SDHB and KIT: a report of two cases and literature review.
    Rasmussen S, Stueck A, Colwell B, Gaston D, Carter M.

    10/29/2022
    Succinate: A Serum Biomarker of SDHB-Mutated Paragangliomas and Pheochromocytomas.

    Succinate: A Serum Biomarker of SDHB-Mutated Paragangliomas and Pheochromocytomas.
    Lamy C, Tissot H, Faron M, Baudin E, Lamartina L, Pradon C, Al Ghuzlan A, Leboulleux S, Perfettini JL, Paci A, Hadoux J, Broutin S.

    10/8/2022
    LncRNA expression and SDHB mutations in pheochromocytomas and paragangliomas.

    LncRNA expression and SDHB mutations in pheochromocytomas and paragangliomas.
    Li H, Hardin H, Zaeem M, Huang W, Hu R, Lloyd RV.

    05/21/2022
    Increased expression of Nrf2 and elevated glucose uptake in pheochromocytoma and paraganglioma with SDHB gene mutation.

    Increased expression of Nrf2 and elevated glucose uptake in pheochromocytoma and paraganglioma with SDHB gene mutation.
    Kamai T, Murakami S, Arai K, Nishihara D, Uematsu T, Ishida K, Kijima T., Free PMC Article

    03/26/2022
    Quantifying evidence toward pathogenicity for rare phenotypes: The case of succinate dehydrogenase genes, SDHB and SDHD.

    Quantifying evidence toward pathogenicity for rare phenotypes: The case of succinate dehydrogenase genes, SDHB and SDHD.
    Garrett A, Loveday C, King L, Butler S, Robinson R, Horton C, Yussuf A, Choi S, Torr B, Durkie M, Burghel GJ, Drummond J, Berry I, Wallace A, Callaway A, Eccles D, Tischkowitz M, Tatton-Brown K, Snape K, McVeigh T, Izatt L, Woodward ER, Burnichon N, Gimenez-Roqueplo AP, Mazzarotto F, Whiffin N, Ware J, Hanson H, Pesaran T, LaDuca H, Buffet A, Maher ER, Turnbull C, Cancer Variant Interpretation Group UK (CanVIG-UK)., Free PMC Article

    03/26/2022
    CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner.

    CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner.
    Sabbir MG, Taylor CG, Zahradka P., Free PMC Article

    02/26/2022
    Loss of SDHB Induces a Metabolic Switch in the hPheo1 Cell Line toward Enhanced OXPHOS.

    Loss of SDHB Induces a Metabolic Switch in the hPheo1 Cell Line toward Enhanced OXPHOS.
    Tabebi M, Kumar Dutta R, Skoglund C, Söderkvist P, Gimm O., Free PMC Article

    02/5/2022
    Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer.

    Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer.
    Aggarwal RK, Luchtel RA, Machha V, Tischer A, Zou Y, Pradhan K, Ashai N, Ramachandra N, Albanese JM, Yang JI, Wang X, Aluri S, Gordon S, Aboumohamed A, Gartrell BA, Hafizi S, Pullman J, Shenoy N., Free PMC Article

    10/9/2021
    MITOCHONDRIA: Succinate dehydrogenase subunit B-associated phaeochromocytoma and paraganglioma.

    MITOCHONDRIA: Succinate dehydrogenase subunit B-associated phaeochromocytoma and paraganglioma.
    Dona M, Neijman K, Timmers HJLM.

    10/2/2021
    One genotype, many phenotypes: SDHB p.R90X mutation-associated paragangliomas.

    One genotype, many phenotypes: SDHB p.R90X mutation-associated paragangliomas.
    Alzahrani AS, Alswailem M, Moria Y, Aldeheshi A, Al-Hindi H.

    08/14/2021
    Differences in Clinical Manifestations and Tumor Features Between Metastatic Pheochromocytoma/Paraganglioma Patients With and Without Germline SDHB Mutation.

    Differences in Clinical Manifestations and Tumor Features Between Metastatic Pheochromocytoma/Paraganglioma Patients With and Without Germline SDHB Mutation.
    Cui Y, Ma X, Wang F, Wang H, Zhou T, Chen S, Tong A, Li Y.

    07/10/2021
    The genetic basis of isolated mitochondrial complex II deficiency.

    The genetic basis of isolated mitochondrial complex II deficiency.
    Fullerton M, McFarland R, Taylor RW, Alston CL., Free PMC Article

    07/3/2021
    Genetic and Clinical Profiles of Pheochromocytoma and Paraganglioma: A Single Center Study.

    Genetic and Clinical Profiles of Pheochromocytoma and Paraganglioma: A Single Center Study.
    Ma X, Li M, Tong A, Wang F, Cui Y, Zhang X, Zhang Y, Chen S, Li Y., Free PMC Article

    06/5/2021
    De novo SDHB gene mutation in a family with extra-adrenal paraganglioma.

    De novo SDHB gene mutation in a family with extra-adrenal paraganglioma.
    Mauer CB, Reys B, Wickiser J.

    05/29/2021
    TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2alpha-Driven Mesenchymal Transition.

    TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.
    Morin A, Goncalves J, Moog S, Castro-Vega LJ, Job S, Buffet A, Fontenille MJ, Woszczyk J, Gimenez-Roqueplo AP, Letouzé E, Favier J.

    03/27/2021
    Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.

    Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
    Wu P, Chen J, Chen J, Tao J, Wu S, Xu G, Wang Z, Wei D, Yin W.

    03/6/2021
    Immunohistochemistry and Mutation Analysis of SDHx Genes in Carotid Paragangliomas.

    Immunohistochemistry and Mutation Analysis of SDHx Genes in Carotid Paragangliomas.
    Snezhkina AV, Kalinin DV, Pavlov VS, Lukyanova EN, Golovyuk AL, Fedorova MS, Pudova EA, Savvateeva MV, Stepanov OA, Poloznikov AA, Demidova TB, Melnikova NV, Dmitriev AA, Krasnov GS, Kudryavtseva AV., Free PMC Article

    02/27/2021
    Variant type is associated with disease characteristics in SDHB, SDHC and SDHD-linked phaeochromocytoma-paraganglioma.

    Variant type is associated with disease characteristics in SDHB, SDHC and SDHD-linked phaeochromocytoma-paraganglioma.
    Bayley JP, Bausch B, Rijken JA, van Hulsteijn LT, Jansen JC, Ascher D, Pires DEV, Hes FJ, Hensen EF, Corssmit EPM, Devilee P, Neumann HPH.

    02/6/2021
    Cardiac paragangliomas: A case series with clinicopathologic features and succinate dehydrogenase B immunostaining.

    Cardiac paragangliomas: A case series with clinicopathologic features and succinate dehydrogenase B immunostaining.
    Alakeel F, Al Sannaa G, Ibarra-Cortez SH, Reardon MJ, Czerniak B, Chan EY, Ro J.

    01/9/2021
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