| m6Am methyltransferase PCIF1 negatively regulates ciliation by inhibiting BICD2 expression. | m6Am methyltransferase PCIF1 negatively regulates ciliation by inhibiting BICD2 expression.
Xie S, Kuang W, Guo M, Yang F, Jin H, Chen X, Yi L, Huo C, Xu Z, Lin A, Liu W, Mao J, Shu Q, Zhou T., | 03/28/2024 |
| The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head and neck squamous cell carcinoma. | The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head and neck squamous cell carcinoma.
Li K, Chen J, Zhang C, Cheng M, Chen S, Song W, Yang C, Ling R, Chen Z, Wang X, Xiong G, Ma J, Zhu Y, Yuan Q, Liu Q, Peng L, Chen Q, Chen D., Free PMC Article | 11/1/2023 |
| Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy. | Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.
Wang L, Wu L, Zhu Z, Zhang Q, Li W, Gonzalez GM, Wang Y, Rana TM., Free PMC Article | 02/11/2023 |
| Effects of the m6Am methyltransferase PCIF1 on cell proliferation and survival in gliomas. | Effects of the m6Am methyltransferase PCIF1 on cell proliferation and survival in gliomas.
Gao S, Zhou J, Hu Z, Zhang S, Wu Y, Musunuru PP, Zhang T, Yang L, Luo X, Bai J, Meng Q, Yu R. | 10/1/2022 |
| Enzymatic characterization of mRNA cap adenosine-N6 methyltransferase PCIF1 activity on uncapped RNAs. | Enzymatic characterization of mRNA cap adenosine-N6 methyltransferase PCIF1 activity on uncapped RNAs.
Yu D, Dai N, Wolf EJ, Corrêa IR Jr, Zhou J, Wu T, Blumenthal RM, Zhang X, Cheng X., Free PMC Article | 05/7/2022 |
| The comprehensive interactomes of human adenosine RNA methyltransferases and demethylases reveal distinct functional and regulatory features. | The comprehensive interactomes of human adenosine RNA methyltransferases and demethylases reveal distinct functional and regulatory features.
Covelo-Molares H, Obrdlik A, Poštulková I, Dohnálková M, Gregorová P, Ganji R, Potěšil D, Gawriyski L, Varjosalo M, Vaňáčová Š., Free PMC Article | 12/25/2021 |
| Methylation of viral mRNA cap structures by PCIF1 attenuates the antiviral activity of interferon-beta. | Methylation of viral mRNA cap structures by PCIF1 attenuates the antiviral activity of interferon-β.
Tartell MA, Boulias K, Hoffmann GB, Bloyet LM, Greer EL, Whelan SPJ., Free PMC Article | 12/18/2021 |
| HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1. | HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1.
Zhang Q, Kang Y, Wang S, Gonzalez GM, Li W, Hui H, Wang Y, Rana TM., Free PMC Article | 10/16/2021 |
| Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima. | Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima.
Yu D, Kaur G, Blumenthal RM, Zhang X, Cheng X., Free PMC Article | 08/28/2021 |
| PCIF1 depletion leads to loss of m6Am RNA modification from the transcriptional-start-sites of mRNAs | Atlas of quantitative single-base-resolution N(6)-methyl-adenine methylomes.
Koh CWQ, Goh YT, Goh WSS., Free PMC Article | 06/11/2020 |
| The authors identified, characterized biochemical property and substrate preference of PCIF1 as "stand-alone" RNA methyltransferase and proposed a model for mammalian mRNA m6Am modification mediated by PCIF1. | Cap-specific, terminal N(6)-methylation by a mammalian m(6)Am methyltransferase.
Sun H, Zhang M, Li K, Bai D, Yi C., Free PMC Article | 03/7/2020 |
| we identify the only human mRNA m6Am methyltransferase and demonstrate a mechanism of gene expression regulation through PCIF1-mediated m6Am mRNA methylation. | PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression.
Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete-Perea J, Sheng W, Gygi SP, Adelman K, Shi Y., Free PMC Article | 01/18/2020 |
| We find that depleting PCIF1 does not substantially affect mRNA translation but is associated with reduced stability of a subset of m(6)Am-annotated mRNAs. The discovery of PCIF1 and our accurate mapping technique will facilitate future studies to characterize m(6)Am's function. | Identification of the m(6)Am Methyltransferase PCIF1 Reveals the Location and Functions of m(6)Am in the Transcriptome.
Boulias K, Toczydłowska-Socha D, Hawley BR, Liberman N, Takashima K, Zaccara S, Guez T, Vasseur JJ, Debart F, Aravind L, Jaffrey SR, Greer EL., Free PMC Article | 01/18/2020 |
| PCIF1/CAPAM (cap-specific adenosine methyltransferase) is a cap-specific N (6)-methyladenosine writer for mRNAs | Cap-specific terminal N (6)-methylation of RNA by an RNA polymerase II-associated methyltransferase.
Akichika S, Hirano S, Shichino Y, Suzuki T, Nishimasu H, Ishitani R, Sugita A, Hirose Y, Iwasaki S, Nureki O, Suzuki T. | 08/3/2019 |
| These results suggest that Pin1 may have overlapping cellular function with PCIF1. | Prolyl isomerase Pin1 shares functional similarity with phosphorylated CTD interacting factor PCIF1 in vertebrate cells.
Yunokuchi I, Fan H, Iwamoto Y, Araki C, Yuda M, Umemura H, Harada F, Ohkuma Y, Hirose Y. | 01/21/2010 |
| These data suggest that icariin exerts its potent osteogenic effect through induction of Runx2 expression, production of BMP-4 and activation of BMP signaling. | Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II.
Hirose Y, Iwamoto Y, Sakuraba K, Yunokuchi I, Harada F, Ohkuma Y. | 01/21/2010 |
| Data suggest that phosphorylated CTD interacting factor 1 (PCIF1) may play a role in mRNA synthesis by modulating RNA polymerase II activity. | PCIF1, a novel human WW domain-containing protein, interacts with the phosphorylated RNA polymerase II.
Fan H, Sakuraba K, Komuro A, Kato S, Harada F, Hirose Y. | 01/21/2010 |