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    PCGEM1 PCGEM1 prostate-specific transcript [ Homo sapiens (human) ]

    Gene ID: 64002, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1.

    Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1.
    Li J, Zhang Y, Sun F, Zhang G, Pan XA, Zhou Q., Free PMC Article

    04/19/2023
    A review on the role of PCGEM1 lncRNA in cancer.

    A review on the role of PCGEM1 lncRNA in cancer.
    Ghafouri-Fard S, Khoshbakht T, Hussen BM, Baniahmad A, Taheri M, Mokhtari M.

    12/17/2022
    LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis.

    LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis.
    Xu W, Wu L, Lu H, Xiang X, Wang F, Li S.

    10/29/2022
    lncRNA PCGEM1 Regulates the Progress of Colorectal Cancer through Targeting miR-129-5p/SOX4.

    lncRNA PCGEM1 Regulates the Progress of Colorectal Cancer through Targeting miR-129-5p/SOX4.
    Guan B, Chen F, Wu Z, Wang C, Yang J., Free PMC Article

    10/15/2022
    Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1beta-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes.

    Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1β-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes.
    Zeng G, Deng G, Xiao S, Li F.

    07/23/2022
    Long non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression.

    Long non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression.
    Fu Q, Wang F, Yang J, Sun W, Hu Z, Xu L, Chu H, Wang X, Zhang W., Free PMC Article

    04/30/2022
    PCGEM1 promotes proliferation, migration and invasion in prostate cancer by sponging miR-506 to upregulate TRIAP1.

    PCGEM1 promotes proliferation, migration and invasion in prostate cancer by sponging miR-506 to upregulate TRIAP1.
    Liu H, He X, Li T, Qu Y, Xu L, Hou Y, Fu Y, Wang H., Free PMC Article

    03/12/2022
    Exosome-transmitted lncRNA PCGEM1 promotes invasive and metastasis in gastric cancer by maintaining the stability of SNAI1.

    Exosome-transmitted lncRNA PCGEM1 promotes invasive and metastasis in gastric cancer by maintaining the stability of SNAI1.
    Piao HY, Guo S, Wang Y, Zhang J.

    08/28/2021
    LncRNA PCGEM1 contributes to malignant behaviors of glioma by regulating miR-539-5p/CDK6 axis.

    LncRNA PCGEM1 contributes to malignant behaviors of glioma by regulating miR-539-5p/CDK6 axis.
    Liu SL, Chen MH, Wang XB, You RK, An XW, Zhao Q, Wang RS., Free PMC Article

    07/24/2021
    LncRNA PCGEM1 accelerates non-small cell lung cancer progression via sponging miR-433-3p to upregulate WTAP.

    LncRNA PCGEM1 accelerates non-small cell lung cancer progression via sponging miR-433-3p to upregulate WTAP.
    Weng L, Qiu K, Gao W, Shi C, Shu F., Free PMC Article

    05/29/2021
    Down-regulation of lncRNA PCGEM1 inhibits cervical carcinoma by modulating the miR-642a-5p/LGMN axis.

    Down-regulation of lncRNA PCGEM1 inhibits cervical carcinoma by modulating the miR-642a-5p/LGMN axis.
    Liu Y, Wang Y, Shen X, Chen C, Ni H, Sheng N, Hua M, Wu Y.

    02/6/2021
    LncRNA PCGEM1 enhances metastasis and gastric cancer invasion through targeting of miR-129-5p to regulate P4HA2 expression.

    LncRNA PCGEM1 enhances metastasis and gastric cancer invasion through targeting of miR-129-5p to regulate P4HA2 expression.
    Zhang T, Piao HY, Guo S, Zhao Y, Wang Y, Zheng ZC, Zhang J.

    12/19/2020
    LncRNA PCGEM1 promotes renal carcinoma progression by targeting miR-433-3p to regulate FGF2 expression.

    LncRNA PCGEM1 promotes renal carcinoma progression by targeting miR-433-3p to regulate FGF2 expression.
    Cai X, Zhang X, Mo L, Zhu J, Yu H.

    12/5/2020
    [Mechanism of long-chain noncoding RNA PCGEM1 in the regulation of the invasion and metastasis of oral squamous carcinoma cells via transforming growth factor beta2/Smad2 signaling pathway].

    [Mechanism of long-chain noncoding RNA PCGEM1 in the regulation of the invasion and metastasis of oral squamous carcinoma cells via transforming growth factor β2/Smad2 signaling pathway].
    Weng X, Li JS, Fan S., Free PMC Article

    10/31/2020
    ROC curve showed that the area values under the curve of exosomal lncRNA PCGEM1 were 0.879, 0.757, and 0.593, respectively

    Synovial fluid-derived exosomal lncRNA PCGEM1 as biomarker for the different stages of osteoarthritis.
    Zhao Y, Xu J.

    02/29/2020
    High expression of PCGEM1 is associated with invasion and metastasis of gastric cancer.

    Hypoxia-induced LncRNA PCGEM1 promotes invasion and metastasis of gastric cancer through regulating SNAI1.
    Zhang J, Jin HY, Wu Y, Zheng ZC, Guo S, Wang Y, Yang D, Meng XY, Xu X, Zhao Y.

    01/11/2020
    we confirmed that PCGEM1 could upregulate the expression of STAT3 by acting as a competing endogenous RNA for miR-129-5p, thereby affecting the occurrence and development of endometrial carcinoma

    The relationship between lncRNA PCGEM1 and STAT3 during the occurrence and development of endometrial carcinoma.
    Li Q, Shen F, Zhao L.

    01/5/2019
    PCGME1 silencing by small interfering RNA significantly induced early cell apoptosis but this effect was reduced by a miR148a inhibitor. In conclusion, the present study demonstrated a positive regulatory association between MEF2 and PCGEM1, and a reciprocal negative regulatory association between PCGEM1 and miR148a that controls cell apoptosis.

    MEF2‑activated long non‑coding RNA PCGEM1 promotes cell proliferation in hormone‑refractory prostate cancer through downregulation of miR‑148a.
    Zhang S, Li Z, Zhang L, Xu Z., Free PMC Article

    10/20/2018
    PCGEM1 may be an inducer in epithelial ovarian cancer tumorigenesis and progression by upregulating RhoA and the subsequent expression of YAP, P70S6K, MMP2, and Bcl-xL.

    LncRNA PCGEM1 Induces Ovarian Carcinoma Tumorigenesis and Progression Through RhoA Pathway.
    Chen S, Wang LL, Sun KX, Liu Y, Guan X, Zong ZH, Zhao Y.

    08/18/2018
    we demonstrate an androgen deprivation-mediated AR3 expression involving PCGEM1 and splicing factors in prostate cancer

    Regulation of androgen receptor splice variant AR3 by PCGEM1.
    Zhang Z, Zhou N, Huang J, Ho TT, Zhu Z, Qiu Z, Zhou X, Bai C, Wu F, Xu M, Mo YY., Free PMC Article

    12/9/2017
    overexpression of PCGEM1 in synoviocytes suppressed miR-770 by direct binding

    PCGEM1 stimulates proliferation of osteoarthritic synoviocytes by acting as a sponge for miR-770.
    Kang Y, Song J, Kim D, Ahn C, Park S, Chun CH, Jin EJ.

    08/6/2016
    PCGEM1 was uniformly distributed in PCa cell nucleus and cytoplasm which remained unaltered upon AR transcriptional activation.

    The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo.
    Parolia A, Crea F, Xue H, Wang Y, Mo F, Ramnarine VR, Liu HH, Lin D, Saidy NR, Clermont PL, Cheng H, Collins C, Wang Y, Helgason CD., Free PMC Article

    01/16/2016
    We demonstrate a reciprocal negative control relationship between PCGEM1 and miR-145 that regulates both LNCaP cell proliferation and nu/nu PCa tumor growth.

    Reciprocal regulation of PCGEM1 and miR-145 promote proliferation of LNCaP prostate cancer cells.
    He JH, Zhang JZ, Han ZP, Wang L, Lv YB, Li YG., Free PMC Article

    09/26/2015
    By being a coactivator for both c-Myc and AR, PCGEM1 reprograms the androgen network and the central metabolism in a tumor-specific way, making it a promising target for therapeutic intervention.

    A long noncoding RNA connects c-Myc to tumor metabolism.
    Hung CL, Wang LY, Yu YL, Chen HW, Srivastava S, Petrovics G, Kung HJ., Free PMC Article

    04/25/2015
    we conclusively demonstrate that PCGEM1 and PRNCR1 are not prognostic lncRNAs in prostate cancer and we refute suggestions that these lncRNAs interact in androgen receptor signaling.

    The IncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer.
    Prensner JR, Sahu A, Iyer MK, Malik R, Chandler B, Asangani IA, Poliakov A, Vergara IA, Alshalalfa M, Jenkins RB, Davicioni E, Feng FY, Chinnaiyan AM., Free PMC Article

    01/24/2015
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