| Regulation of ABCG4 transporter expression by sterols and LXR ligands. | Regulation of ABCG4 transporter expression by sterols and LXR ligands.
Yang A, Alrosan AZ, Sharpe LJ, Brown AJ, Callaghan R, Gelissen IC. | 01/16/2021 |
| Alix serves as a co-factor for the interaction between the E3-ubiquitin ligase NEDD4-1 and the ABC transporter targets, ABCG1 and ABCG4. | The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4.
Alrosan A, Aleidi SM, Yang A, Brown AJ, Gelissen IC., Free PMC Article | 11/23/2019 |
| Intriguingly, DU-145 cells with stably depleted ABCG4 levels not only significantly delayed the development of the tumor but also greatly sensitized the tumor to a low dose of doxorubicin that resulted in complete tumor regression. Collectively, this data reinforces a novel function of ABCG4 in doxorubicin-mediated chemoresistance, and as a potential therapeutic target in drug-induced prostate cancer chemoresistance. | Doxorubicin induces prostate cancer drug resistance by upregulation of ABCG4 through GSH depletion and CREB activation: Relevance of statins in chemosensitization.
Mallappa S, Neeli PK, Karnewar S, Kotamraju S. | 11/9/2019 |
| We show for the first time that Abcg4 may function in vivo to export Abeta at the BBB, in a process that can be antagonized by its putative natural ligand, desmosterol (and possibly cholesterol). | Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-β peptide.
Dodacki A, Wortman M, Saubaméa B, Chasseigneaux S, Nicolic S, Prince N, Lochus M, Raveu AL, Declèves X, Scherrmann JM, Patel SB, Bourasset F., Free PMC Article | 07/6/2019 |
| Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes | Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes.
Deng L, Wang X, Jiang L, Yang J, Zhou X, Lu Z, Hu H. | 11/4/2017 |
| ABCG1 and ABCG4 alter the distribution of gamma-secretase on the plasma membrane, leading to the decreased gamma-secretase activity and suppressed Abeta secretion | ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.
Sano O, Tsujita M, Shimizu Y, Kato R, Kobayashi A, Kioka N, Remaley AT, Michikawa M, Ueda K, Matsuo M., Free PMC Article | 07/15/2017 |
| Both the full-length and the short isoforms of ABCG1 can dimerize with ABCG4, whereas the ABCG2 multidrug transporter is unable to form a heterodimer with ABCG4. | Functional Cooperativity between ABCG4 and ABCG1 Isoforms.
Hegyi Z, Homolya L., Free PMC Article | 07/8/2017 |
| Study suggests that high ABCG4 expression is associated with poor prognosis in patients with non-small-cell lung cancer with advanced stages. | High ABCG4 Expression Is Associated with Poor Prognosis in Non-Small-Cell Lung Cancer Patients Treated with Cisplatin-Based Chemotherapy.
Yang G, Wang XJ, Huang LJ, Zhou YA, Tian F, Zhao JB, Chen P, Liu BY, Wen MM, Li XF, Zhang ZP., Free PMC Article | 05/21/2016 |
| HUWE1 and NEDD4-1 are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 and ABCG4 protein levels and cellular cholesterol export activity | The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.
Aleidi SM, Howe V, Sharpe LJ, Yang A, Rao G, Brown AJ, Gelissen IC., Free PMC Article | 01/16/2016 |
| These results suggest that ABCA1, ABCG1, and ABCG4 are localized to distinct membrane meso-domains and disturb the meso-domain structures by reorganizing lipids on the plasma membrane | ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane.
Sano O, Ito S, Kato R, Shimizu Y, Kobayashi A, Kimura Y, Kioka N, Hanada K, Ueda K, Matsuo M., Free PMC Article | 06/27/2015 |
| This study demonstreated that Abcg4 acts in concert with Abcg2 to efflux Abeta from the brain across the blood-brain barrier. | ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier.
Do TM, Noel-Hudson MS, Ribes S, Besengez C, Smirnova M, Cisternino S, Buyse M, Calon F, Chimini G, Chacun H, Scherrmann JM, Farinotti R, Bourasset F. | 09/15/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) | Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF., Free PMC Article | 04/7/2010 |
| Human ABC transporters ABCG2 (BCRP) and ABCG4 | Human ABC transporters ABCG2 (BCRP) and ABCG4.
Koshiba S, An R, Saito H, Wakabayashi K, Tamura A, Ishikawa T. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. | 09/24/2008 |
| ABCG4 is highly expressed in microglia on alzheimer disease brain. | ATP-binding cassette transporter G4 is highly expressed in microglia in Alzheimer's brain.
Uehara Y, Yamada T, Baba Y, Miura S, Abe S, Kitajima K, Higuchi MA, Iwamoto T, Saku K. | 01/21/2010 |
| ABCG4 is expressed specifically in the brain and the eye. | ABCG4: a novel human white family ABC-transporter expressed in the brain and eye.
Oldfield S, Lowry C, Ruddick J, Lightman S. | 01/21/2010 |
| ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles | ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.
Vaughan AM, Oram JF. | 01/21/2010 |
| Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4: maps to human chromosome 11, is expressed abundantly in brain, and has alternatively-spliced isoforms | Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4.
Annilo T, Tammur J, Hutchinson A, Rzhetsky A, Dean M, Allikmets R. | 01/21/2010 |
| ABCG4 may be involved in macrophage lipid homeostasis. | The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages.
Engel T, Lorkowski S, Lueken A, Rust S, Schlüter B, Berger G, Cullen P, Assmann G. | 11/26/2001 |