| Mitochondrial transcription factor B2 overexpression increases M2 macrophage infiltration via cytosolic mitochondrial DNA-stimulated Interleukin-6 secretion in ovarian cancer. | Mitochondrial transcription factor B2 overexpression increases M2 macrophage infiltration via cytosolic mitochondrial DNA-stimulated Interleukin-6 secretion in ovarian cancer.
Wu W, Zhou S, Liu T, Liang D., Free PMC Article | 06/11/2022 |
| TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. | TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication.
Inatomi T, Matsuda S, Ishiuchi T, Do Y, Nakayama M, Abe S, Kasho K, Wanrooij S, Nakada K, Ichiyanagi K, Sasaki H, Yasukawa T, Kang D. | 01/1/2022 |
| Over-expression of TFB2M facilitates cell growth and metastasis via activating ROS-Akt-NF-kappaB signalling in hepatocellular carcinoma. | Over-expression of TFB2M facilitates cell growth and metastasis via activating ROS-Akt-NF-κB signalling in hepatocellular carcinoma.
Geng X, Geng Z, Li H, Zhang Y, Li J, Chang H. | 08/28/2021 |
| Phosphorylation of mitochondrial transcription factor B2 controls mitochondrial DNA binding and transcription. | Phosphorylation of mitochondrial transcription factor B2 controls mitochondrial DNA binding and transcription.
Bostwick AM, Moya GE, Senti ML, Basu U, Shen J, Patel SS, Dittenhafer-Reed KE., Free PMC Article | 02/13/2021 |
| a rare homozygous c.790C>T (His264Tyr) variation in TFB2M gene in two Korean siblings with autism spectrum disorder by whole-exome sequencing, is reported. | Identification of a rare homozygous c.790C>T variation in the TFB2M gene in Korean patients with autism spectrum disorder.
Park CB, Choi VN, Jun JB, Kim JH, Lee Y, Lee J, Lim G, Kim J, Jeong SY, Yim SY. | 05/18/2019 |
| Study reports crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mitochondrial RNA polymerase to achieve promoter-dependent initiation. | Structural Basis of Mitochondrial Transcription Initiation.
Hillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P., Free PMC Article | 12/16/2017 |
| demonstrate that a complex composed of TFAM and POLRMT was readily formed at the promoter but alone was insufficient for promoter melting, which only occurred when TFB2M joined the complex | Human Mitochondrial Transcription Factor B2 Is Required for Promoter Melting during Initiation of Transcription.
Posse V, Gustafsson CM., Free PMC Article | 07/8/2017 |
| The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex. | Organization of the human mitochondrial transcription initiation complex.
Yakubovskaya E, Guja KE, Eng ET, Choi WS, Mejia E, Beglov D, Lukin M, Kozakov D, Garcia-Diaz M., Free PMC Article | 06/28/2014 |
| only two essential initiation factors, TFAM and TFB2M, and two promoters, LSP and HSP1, are required to drive transcription of the mitochondrial genome | Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro.
Litonin D, Sologub M, Shi Y, Savkina M, Anikin M, Falkenberg M, Gustafsson CM, Temiakov D., Free PMC Article | 07/5/2010 |
| The mRNA levels of TFB1M and TFB2M are influenced by endurance training | Training response of mitochondrial transcription factors in human skeletal muscle.
Norrbom J, Wallman SE, Gustafsson T, Rundqvist H, Jansson E, Sundberg CJ. | 03/8/2010 |
| Promoter-independent DNA conformation-dependent transcription required TFB2M. | DNA conformation-dependent activities of human mitochondrial RNA polymerase.
Fukuoh A, Ohgaki K, Hatae H, Kuraoka I, Aoki Y, Uchiumi T, Jacobs HT, Kang D. | 01/21/2010 |
| This study suggested that DNA variants in TFB2M did not contribute to the risk for parkinson disease. | Mutational screening of the mitochondrial transcription factors B1 and B2 (TFB1M and TFB2M) in Parkinson's disease.
Sánchez-Ferrero E, Coto E, Blázquez M, Ribacoba R, Guisasola LM, Salvador C, Alvarez V, Sánchez-Ferrero E, Coto E, Blázquez M, Ribacoba R, Guisasola LM, Salvador C, Alvarez V. | 01/21/2010 |
| rRNA methyltransferase activity is necessary for induction of mitochondrial biogenesis by TFB1M, but not TFB2M. | Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness.
Cotney J, McKay SE, Shadel GS., Free PMC Article | 01/21/2010 |
| determined the variation in the TFAM, TFB1M, and TFB2M genes in cardiac hypertrophy | Mitochondrial transcription factors TFA, TFB1 and TFB2: a search for DNA variants/haplotypes and the risk of cardiac hypertrophy.
Alonso-Montes C, Castro MG, Reguero JR, Perrot A, Ozcelik C, Geier C, Posch MG, Morís C, Alvarez V, Ruiz-Ortega M, Coto E, Alonso-Montes C, Castro MG, Reguero JR, Perrot A, Ozcelik C, Geier C, Posch MG, Morís C, Alvarez V, Ruiz-Ortega M, Coto E., Free PMC Articles: PMC3827797, PMC3827797 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Mitochondrial transcription factors TFA, TFB1 and TFB2: a search for DNA variants/haplotypes and the risk of cardiac hypertrophy.
Alonso-Montes C, Castro MG, Reguero JR, Perrot A, Ozcelik C, Geier C, Posch MG, Morís C, Alvarez V, Ruiz-Ortega M, Coto E, Alonso-Montes C, Castro MG, Reguero JR, Perrot A, Ozcelik C, Geier C, Posch MG, Morís C, Alvarez V, Ruiz-Ortega M, Coto E. Mutational screening of the mitochondrial transcription factors B1 and B2 (TFB1M and TFB2M) in Parkinson's disease.
Sánchez-Ferrero E, Coto E, Blázquez M, Ribacoba R, Guisasola LM, Salvador C, Alvarez V, Sánchez-Ferrero E, Coto E, Blázquez M, Ribacoba R, Guisasola LM, Salvador C, Alvarez V. | 11/19/2008 |
| This transcription factor activates transcription of human mitochondrial DNA. | Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.
Falkenberg M, Gaspari M, Rantanen A, Trifunovic A, Larsson NG, Gustafsson CM. | 01/21/2010 |
| Distinct, but possibly coordinated functions of mtTFB1 and mtTFB2 in mitochondrial gene expression and biogenesis. | Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.
Cotney J, Wang Z, Shadel GS., Free PMC Article | 01/21/2010 |