| Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m(6)A demethylation of EIF4EBP1 and MLST8 mRNA. | Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m(6)A demethylation of EIF4EBP1 and MLST8 mRNA.
Zhang L, Su X., Free PMC Article | 06/25/2022 |
| CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma. | CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma.
Zhang E, Chen S, Tang H, Fei C, Yuan Z, Mu X, Qin Y, Liu H, Fan Y, Tan M, Wang X., Free PMC Article | 01/15/2022 |
| STAT3-mediated MLST8 gene expression regulates cap-dependent translation in cancer cells. | STAT3-mediated MLST8 gene expression regulates cap-dependent translation in cancer cells.
Lee H, Chin H, Kim H, Jung H, Lee D., Free PMC Article | 07/3/2021 |
| ASO Author Reflections: mLST8 is a Prognostic Biomarker and Involved in Tumor Progression in Hepatocellular Carcinoma. | ASO Author Reflections: mLST8 is a Prognostic Biomarker and Involved in Tumor Progression in Hepatocellular Carcinoma.
Yu XN, Shen XZ, Guo HY, Zhu JM. | 01/23/2021 |
| Enhanced mLST8 Expression Correlates with Tumor Progression in Hepatocellular Carcinoma. | Enhanced mLST8 Expression Correlates with Tumor Progression in Hepatocellular Carcinoma.
Yu XN, Zhang GC, Sun JL, Zhu HR, Shi X, Song GQ, Weng SQ, Dong L, Liu TT, Shen XZ, Guo HY, Zhu JM. | 01/16/2021 |
| NEAT1 was potentially communicated with mTOR signaling target protein mLST8 via the association with miR-181b in type 2 diabetes mellitus. | Construction of competitive endogenous RNA network reveals regulatory role of long non-coding RNAs in type 2 diabetes mellitus.
Lin Z, Li X, Zhan X, Sun L, Gao J, Cao Y, Qiu H., Free PMC Article | 07/14/2018 |
| Autophagy regulates c-MET phosphorylation via an mTORC2-dependent mechanism. | mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism.
Lampada A, O'Prey J, Szabadkai G, Ryan KM, Hochhauser D, Salomoni P., Free PMC Article | 03/31/2018 |
| Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus. | The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.
Hao F, Itoh T, Morita E, Shirahama-Noda K, Yoshimori T, Noda T., Free PMC Article | 08/13/2016 |
| MLST8 upregulation may contribute to tumor progression. | mLST8 Promotes mTOR-Mediated Tumor Progression.
Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C., Free PMC Article | 04/9/2016 |
| Amino acids promote mTORC1 activation without altering Rag GTP charging. | Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.
Oshiro N, Rapley J, Avruch J., Free PMC Article | 04/12/2014 |
| MLST8 polymorphism is associated with gastric cancer. | Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.
He J, Wang MY, Qiu LX, Zhu ML, Shi TY, Zhou XY, Sun MH, Yang YJ, Wang JC, Jin L, Wang YN, Li J, Yu HP, Wei QY. | 12/21/2013 |
| The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8. | Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes.
Nakashima A, Kawanishi I, Eguchi S, Yu EH, Eguchi S, Oshiro N, Yoshino K, Kikkawa U, Yonezawa K., Free PMC Article | 09/7/2013 |
| An essential role of mTORC1 in autophagy inhibition in cell-free system in which, membrane association of Barkor/Atg14(L), a specific autophagosome-binding protein, is suppressed by cytosol from nutrient-rich medium, is shown. | Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro.
Yan X, Sun Q, Ji J, Zhu Y, Liu Z, Zhong Q., Free PMC Article | 09/12/2012 |
| show that E2F1 is capable of inducing growth by regulating mTORC1 activity | E2F1 regulates cellular growth by mTORC1 signaling.
Real S, Meo-Evoli N, Espada L, Tauler A., Free PMC Article | 09/12/2012 |
| Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4 | Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4.
Ding M, Xie Y, Wagner RJ, Jin Y, Carrao AC, Liu LS, Guzman AK, Powell RJ, Hwa J, Rzucidlo EM, Martin KA., Free PMC Article | 09/12/2012 |
| results suggest that GRp58/ERp57 is involved in the assembly of mTORC1 and positively regulates mTORC1 signaling at the cytosol and the cytosolic side of the endoplasmic reticulum | Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57.
Ramírez-Rangel I, Bracho-Valdés I, Vázquez-Macías A, Carretero-Ortega J, Reyes-Cruz G, Vázquez-Prado J., Free PMC Article | 09/12/2012 |