| Regulation of Cardiac Fibroblast GLS1 Expression by Scleraxis. | Regulation of Cardiac Fibroblast GLS1 Expression by Scleraxis.
Chattopadhyaya S, Nagalingam RS, Ledingham DA, Moffatt TL, Al-Hattab DS, Narhan P, Stecy MT, O'Hara KA, Czubryt MP., Free PMC Article | 05/28/2022 |
| The transcription factor scleraxis differentially regulates gene expression in tenocytes isolated at different developmental stages. | The transcription factor scleraxis differentially regulates gene expression in tenocytes isolated at different developmental stages.
Paterson YZ, Evans N, Kan S, Cribbs A, Henson FMD, Guest DJ. | 08/14/2021 |
| The Transcription Factor SCX is a Potential Serum Biomarker of Fibrotic Diseases. | The Transcription Factor SCX is a Potential Serum Biomarker of Fibrotic Diseases.
Ramírez-Aragón M, Hernández-Sánchez F, Rodríguez-Reyna TS, Buendía-Roldán I, Güitrón-Castillo G, Núñez-Alvarez CA, Hernández-Ramírez DF, Benavides-Suárez SA, Esquinca-González A, Torres-Machorro AL, Mendoza-Milla C., Free PMC Article | 02/27/2021 |
| Scleraxis as a prognostic marker of myocardial fibrosis in hypertrophic cardiomyopathy (SPARC) study. | Scleraxis as a prognostic marker of myocardial fibrosis in hypertrophic cardiomyopathy (SPARC) study.
Zhu A, Bews H, Cheung D, Nagalingam RS, Mittal I, Goyal V, Asselin CY, Kirkpatrick IDC, Czubryt MP, Jassal DS. | 02/13/2021 |
| Tenogenic Contribution to Skeletal Muscle Regeneration: The Secretome of Scleraxis Overexpressing Mesenchymal Stem Cells Enhances Myogenic Differentiation In Vitro. | Tenogenic Contribution to Skeletal Muscle Regeneration: The Secretome of Scleraxis Overexpressing Mesenchymal Stem Cells Enhances Myogenic Differentiation In Vitro.
Strenzke M, Alberton P, Aszodi A, Docheva D, Haas E, Kammerlander C, Böcker W, Saller MM., Free PMC Article | 12/5/2020 |
| Scleraxis regulates epithelial-mesenchymal transition via direct transactivation of the Twist1 and Snai1 genes. | Scleraxis regulates Twist1 and Snai1 expression in the epithelial-to-mesenchymal transition.
Al-Hattab DS, Safi HA, Nagalingam RS, Bagchi RA, Stecy MT, Czubryt MP. | 04/11/2020 |
| The transcription factor scleraxis is an important inducer of extracellular matrix gene expression in the heart that also control MMP2 expression. The scleraxis can exert control over both extracellular matrix synthesis and breakdown, and thus may contribute to matrix remodeling in wound healing and disease. | Regulation of cardiac fibroblast MMP2 gene expression by scleraxis.
Nagalingam RS, Safi HA, Al-Hattab DS, Bagchi RA, Landry NM, Dixon IMC, Wigle JT, Czubryt MP. | 10/26/2019 |
| Abnormal upregulation of HIF-2alpha served as a key switch to direct TSPCs differentiation into osteochondral-lineage rather than teno-lineage. Notably, Scleraxis (Scx), an essential tendon specific transcription factor, was suppressed on constitutive activation of HIF-2alpha and mediated the effect of HIF-2alpha on TSPCs fate decision. | Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment.
Hu JJ, Yin Z, Shen WL, Xie YB, Zhu T, Lu P, Cai YZ, Kong MJ, Heng BC, Zhou YT, Chen WS, Chen X, Ouyang HW. | 01/14/2017 |
| These studies identify an important role for Scx in regulating proteoglycans in embryonic and mature valve cells. | Tgfβ-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves.
Barnette DN, Hulin A, Ahmed AS, Colige AC, Azhar M, Lincoln J., Free PMC Article | 06/28/2014 |
| Scleraxis thus appears to play a key role in the transcriptional regulation of type I collagen synthesis. | Synergistic roles of scleraxis and Smads in the regulation of collagen 1α2 gene expression.
Bagchi RA, Czubryt MP. | 04/15/2014 |
| collagen type I and several T/L-related proteoglycans were upregulated in hMSC-Scx cells | Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis.
Alberton P, Popov C, Prägert M, Kohler J, Shukunami C, Schieker M, Docheva D., Free PMC Article | 04/15/2014 |
| High glucose inhibited osteogenetic differentiation of periodontal ligament cells and up-regulated Scleraxis expression. | [Effect of high glucose on the expression of transcription factor Scleraxis in periodontal ligament cells in vitro].
Yuan YD, Miao S, Xie H. | 04/15/2014 |
| Scx and E47 might modulate the primary chondrogenesis by associating with the Sox9-related transcriptional complex, and by binding to the conserved E-box on Col2a1 promoter. | Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription.
Furumatsu T, Shukunami C, Amemiya-Kudo M, Shimano H, Ozaki T. | 04/15/2014 |
| Scleraxis was expressed in periodontal ligament cells, bone marrow cells, and gingival fibroblasts, and may play an important role in differentiation of periodontal ligament cells. | [Expression of Scleraxis in human periodontal ligament cells and gingival fibroblasts].
Liu Q, Xie H, Li WY, Li CZ. | 04/15/2014 |