| CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability. | CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
Zhang M, Yang C, Ruan X, Liu X, Wang D, Liu L, Shao L, Wang P, Dong W, Xue Y., Free PMC Article | 09/24/2022 |
| Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders. | Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders.
Szczepankiewicz D, Narożna B, Celichowski P, Sakrajda K, Kołodziejski P, Banach E, Zakowicz P, Pruszyńska-Oszmałek E, Pawlak J, Wiłkość M, Dmitrzak-Węglarz M, Skibińska M, Bejger A, Twarowska-Hauser J, Rybakowski JK, Nogowski L, Szczepankiewicz A. | 08/21/2021 |
| Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells. | Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells.
Yan J, Zhang D, Han Y, Wang Z, Ma C. | 09/19/2020 |
| In this study, we uncover an alternative role for the ESCRT-0 component hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) in promoting the constitutive recycling of transmembrane proteins. We find that endosomal localization of the actin nucleating factor Wiscott-Aldrich syndrome protein and SCAR homologue (WASH) requires HRS, which occupies adjacent endosomal subdomains | HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.
MacDonald E, Brown L, Selvais A, Liu H, Waring T, Newman D, Bithell J, Grimes D, Urbé S, Clague MJ, Zech T., Free PMC Article | 05/25/2019 |
| Cold induction of serine and arginine rich splicing factor 5 (SRSF5) is independent of cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3). | TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3.
Fujita T, Higashitsuji H, Higashitsuji H, Liu Y, Itoh K, Sakurai T, Kojima T, Kandori S, Nishiyama H, Fukumoto M, Fukumoto M, Shibasaki K, Fujita J., Free PMC Article | 01/12/2019 |
| Study found that SRSF5 is a novel target of SRSF3. SRSF5 is overexpressed in oral squamous cell carcinoma (OSCC) and functions as an oncogene. Its downregulation in OSCC cell lines slows cell growth, cycle progression, and tumor growth. The expression of SRSF5 seems to controlled by an autoregulation mechanism. | SRSF5 functions as a novel oncogenic splicing factor and is upregulated by oncogene SRSF3 in oral squamous cell carcinoma.
Yang S, Jia R, Bian Z. | 12/22/2018 |
| upon glucose intake, the splicing factor SRSF5 is specifically induced through Tip60-mediated acetylation on K125, which antagonizes Smurf1-mediated ubiquitylation. SRSF5 promotes the alternative splicing of CCAR1 to produce CCAR1S proteins, which promote tumor growth by enhancing glucose consumption and acetyl-CoA production. | Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.
Chen Y, Huang Q, Liu W, Zhu Q, Cui CP, Xu L, Guo X, Wang P, Liu J, Dong G, Wei W, Liu CH, Feng Z, He F, Zhang L., Free PMC Article | 12/22/2018 |
| we show that ErbB3 interacts with the ESCRT-0 subunit Hrs both in the presence and absence of heregulin. This indicates an ESCRT-mediated sorting of ErbB3 to late endosomes and lysosomes, and in line with this we show that impaired ESCRT function leads to an endosomal accumulation of ErbB3. | ErbB3 interacts with Hrs and is sorted to lysosomes for degradation.
Fosdahl AM, Dietrich M, Schink KO, Malik MS, Skeie M, Bertelsen V, Stang E. | 02/10/2018 |
| the up-regulated expression of SRSF 5-7 proteins in LC with much more profound up-regulation in SCLC than in NSCLC and suggest that up-regulation of the SRSFs is related to SCLC proliferation. Moreover, we identified SRSF5 as a novel detection marker for SCLC and pleural metastatic cancer cells. | SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer.
Kim HR, Lee GO, Choi KH, Kim DK, Ryu JS, Hwang KE, Na KJ, Choi C, Kuh JH, Chung MJ, Lee MK, So HS, Yoon KH, Park MC, Na KS, Kim YS, Park DS. | 12/9/2017 |
| this study demonstrates that HRS acts as a key component of TLR7 signaling to orchestrate immune and inflammatory responses during EV71 infection | HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection.
Luo Z, Ge M, Chen J, Geng Q, Tian M, Qiao Z, Bai L, Zhang Q, Zhu C, Xiong Y, Wu K, Liu F, Liu Y, Wu J., Free PMC Article | 10/7/2017 |
| Posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells. | Cellular differentiation state modulates the mRNA export activity of SR proteins.
Botti V, McNicoll F, Steiner MC, Richter FM, Solovyeva A, Wegener M, Schwich OD, Poser I, Zarnack K, Wittig I, Neugebauer KM, Müller-McNicoll M., Free PMC Article | 09/16/2017 |
| Enhanced SRSF5 Protein Expression Reinforces Lamin A mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients | Enhanced SRSF5 Protein Expression Reinforces Lamin A mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients.
Vautrot V, Aigueperse C, Oillo-Blanloeil F, Hupont S, Stevenin J, Branlant C, Behm-Ansmant I. | 12/24/2016 |
| Suggest that SRp40 might be associated with GRalpha transcripts in systemic lupus erythematosus patients. | Expression of glucocorticoid receptor isoforms and associations with serine/arginine-rich protein 30c and 40 in patients with systemic lupus erythematosus.
Guan YC, Jiang L, Ma LL, Sun XN, Yu DD, Liu J, Qu DX, Fang MY. | 05/30/2015 |
| We show that changes in alternative splicing of hnRNP A/B, affected by up regulation of SRSF5 (SRp40) or by treatment with C6-ceramide, occur within supraspliceosomes. | Regulation of alternative splicing within the supraspliceosome.
Sebbag-Sznajder N, Raitskin O, Angenitzki M, Sato TA, Sperling J, Sperling R., Free PMC Article | 05/12/2012 |
| Relative levels of SRp20, SRp30c, and SRp40 in TM cells control differential expression of the two alternatively spliced isoforms of the GR and thereby regulate GC responsiveness. | Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells.
Jain A, Wordinger RJ, Yorio T, Clark AF., Free PMC Article | 04/28/2012 |
| Here, the authors report that specific SR proteins, particularly SRp40 and SRp55, promote human immunodeficiency virus type 1 (HIV-1) Gag translation from unspliced (intron-containing) viral RNA. | SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA.
Swanson CM, Sherer NM, Malim MH., Free PMC Article | 07/5/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders.
Fingert JH, Alward WL, Wang K, Yorio T, Clark AF., Free PMC Article | 06/30/2010 |
| SRp40 antagonizes ASF/SF2 and SRp55 by competing for binding to certain sites in exon 5, thereby promoting TF exon 5 exclusion, an event unique to asTF biosynthesis. | Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells.
Chandradas S, Deikus G, Tardos JG, Bogdanov VY., Free PMC Article | 02/8/2010 |
| role in c-H-ras alternative splicing regulation | Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation.
Guil S, Gattoni R, Carrascal M, Abián J, Stévenin J, Bach-Elias M., Free PMC Article | 01/21/2010 |
| SRp40 regulates the switch in splicing from production of CREMtau(2)alpha to CREMalpha | The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40.
Tyson-Capper AJ, Bailey J, Krainer AR, Robson SC, Europe-Finner GN. | 01/21/2010 |
| SC35, SRp40, and heterogeneous nuclear ribonucleoprotein A1 interact competitively at the HIV-1 Tat exon 2 splicing site | Biochemical and NMR study on the competition between proteins SC35, SRp40, and heterogeneous nuclear ribonucleoprotein A1 at the HIV-1 Tat exon 2 splicing site.
Hallay H, Locker N, Ayadi L, Ropers D, Guittet E, Branlant C. | 01/21/2010 |
| activates the ESE (exon splicing enhancer) which regulates HIV-1 rev, env, vpu, and nef gene expression | A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression.
Caputi M, Freund M, Kammler S, Asang C, Schaal H., Free PMC Article | 01/21/2010 |
| SR proteins 9G8, SC35, ASF/SF2, and SRp40 have effects on the utilization of the A1 to A5 splicing sites of HIV-1 RNA | Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA.
Ropers D, Ayadi L, Gattoni R, Jacquenet S, Damier L, Branlant C, Stévenin J. | 01/21/2010 |