| Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer. | Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer.
Cao K, Liu Z, Liu J, Hu Q, Shan W, Hu B, Shi H, Zhang B. | 11/20/2023 |
| Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway. | Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway.
Zhao B, Wu J, Cha X, Mao G, Shi H, Fei S, Miao B., Free PMC Article | 04/10/2023 |
| A COP1-GATA2 axis suppresses AR signaling and prostate cancer. | A COP1-GATA2 axis suppresses AR signaling and prostate cancer.
Shen T, Dong B, Meng Y, Moore DD, Yang F., Free PMC Article | 10/22/2022 |
| COP1 Acts as a Ubiquitin Ligase for PCDH9 Ubiquitination and Degradation in Human Glioma. | COP1 Acts as a Ubiquitin Ligase for PCDH9 Ubiquitination and Degradation in Human Glioma.
Zhou K, Wang L, Sun Z, Liu Y, Zhu Y, Liu Z, Zhang B, Shi H. | 04/30/2022 |
| Role of the COP1 protein in cancer development and therapy. | Role of the COP1 protein in cancer development and therapy.
Song Y, Liu Y, Pan S, Xie S, Wang ZW, Zhu X. | 09/18/2021 |
| RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma. | RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma.
Gu C, Lu T, Wang W, Shao M, Wei R, Guo M, Li R, Qiao L, Hu Y, Zhan F, Seckinger A, Hose D, Yang Y. | 08/21/2021 |
| Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPbeta in Microglia. | Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
Ndoja A, Reja R, Lee SH, Webster JD, Ngu H, Rose CM, Kirkpatrick DS, Modrusan Z, Chen YJ, Dugger DL, Gandham V, Xie L, Newton K, Dixit VM. | 05/8/2021 |
| Palmitate induces COP1 expression in hepG2 cells. COP1 functioned as an E3 Ub-ligase of SIRT1, responsible for its proteasomal degradation under lipotoxic conditions. TRB3 recruited COP1 to SIRT1 to promote its ubiquitination.The TRB3-COP1-SIRT1 pathway played an important role in lipotoxicity leading to insulin resistance in hepatocytes. | TRB3 stimulates SIRT1 degradation and induces insulin resistance by lipotoxicity via COP1.
Ren X, Chen N, Chen Y, Liu W, Hu Y. | 06/27/2020 |
| COP1 role in the proteasomal degradation of ATGL in hepatocytes. | PEDF promotes nuclear degradation of ATGL through COP1.
Niyogi S, Ghosh M, Adak M, Chakrabarti P. | 04/11/2020 |
| COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. | COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.
Xie Y, Cao Z, Wong EW, Guan Y, Ma W, Zhang JQ, Walczak EG, Murphy D, Ran L, Sirota I, Wang S, Shukla S, Gao D, Knott SR, Chang K, Leu J, Wongvipat J, Antonescu CR, Hannon G, Chi P, Chen Y., Free PMC Article | 09/14/2019 |
| COP1 overexpression inhibits p53 expression induced by fludarabine and promotes ubiquitin-mediated p53 degradation in chronic lymphocytic leukemia cells. | Constitutively Photomorphogenic 1 Reduces the Sensitivity of Chronic Lymphocytic Leukemia Cells to Fludarabine Through Promotion of Ubiquitin-Mediated P53 Degradation.
Fu C, Shi X, Gong Y, Wan Y, Sun Z, Shi H, Wang Z, Marinaccio C, Crispino JD, Xu K. | 12/22/2018 |
| COP1 regulates human breast cancer cell proliferation and apoptosis in a p53-dependent manner.The COP1-mediated degradation of p53 regulates cancer cell growth and apoptosis. | The ubiquitin ligase COP1 regulates cell cycle and apoptosis by affecting p53 function in human breast cancer cell lines.
Ka WH, Cho SK, Chun BN, Byun SY, Ahn JC. | 11/17/2018 |
| that COP1 may play a role in promoting glioma cell proliferation by interacting with and downregulating tumor suppressor p53 rather than oncogenic protein c-JUN | The Ubiquitin Ligase COP1 Promotes Glioma Cell Proliferation by Preferentially Downregulating Tumor Suppressor p53.
Zou S, Zhu Y, Wang B, Qian F, Zhang X, Wang L, Fu C, Bao H, Xie M, Gao S, Yu R, Shi H. | 05/12/2018 |
| COP1 forms complex with p53 protein and plays a role in p53 down-regulation. | Imaging and kinetics of the bimolecular complex formed by the tumor suppressor p53 with ubiquitin ligase COP1 as studied by atomic force microscopy and surface plasmon resonance.
Moscetti I, Bizzarri AR, Cannistraro S., Free PMC Article | 04/14/2018 |
| Authors demonstrate that mtp53 prevents the COP1/DET1 complex from ubiquitinating ETS2 and thereby marking it for destruction. Authors show that mtp53 destabilizes DET1 and also disrupts the DET1/ETS2 complex thereby preventing ETS2 degradation. | Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation.
Carrero ZI, Kollareddy M, Chauhan KM, Ramakrishnan G, Martinez LA., Free PMC Article | 12/23/2017 |
| STK40 binds the COP1 WD40 domain using a VPD/E motif in its C-terminal tail. | STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.
Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC., Free PMC Article | 10/7/2017 |
| In conclusion, miR-214 functions as a tumor suppressor by regulating the RFWD2-p53 cascade, thus delivery of miR-214 analogs could be a potential adjunct therapy in breast cancer harboring wild type p53. | miR-214 promotes apoptosis and sensitizes breast cancer cells to doxorubicin by targeting the RFWD2-p53 cascade.
Zhang J, Su B, Gong C, Xi Q, Chao T. | 05/27/2017 |
| the reduced expression of COP1 and the upregulated expression of ETV1 in RCC tissue samples, which was associated with a high tumor-node-metastasis stage of RCC. Furthermore, the overexpression of COP1 in the RCC ACHN cells inhibited the migration and invasion of ACHN cells, and downregulated ETV1 and MMP7 expression levels. | COP1 is downregulated in renal cell carcinoma (RCC) and inhibits the migration of RCC ACHN cells in vitro.
Ta L, Xuan C, Xing N, Zhu X. | 04/8/2017 |
| COP1 expression was an independent predictor of overall survival. | High expression of constitutive photomorphogenic 1 (COP1) is associated with poor prognosis in bladder cancer.
Li J, Wang L, Xiao R, Pan Q, Huang H, Kuang R. | 02/18/2017 |
| protein level changes lead to increased sensitivity toward cisplatin treatment, implicating that huCOP1 plays a positive role in maintaining genome integrity in human keratinocytes. | HuCOP1 contributes to the regulation of DNA repair in keratinocytes.
Fazekas B, Carty MP, Németh I, Kemény L, Széll M, Ádám É. | 02/18/2017 |
| the present study revealed that COP1 plays an important role in CLL cell proliferation and tumorigenicity, and may be a useful indicator of the chronic lymphocytic leukemia processes. | Expression and regulation of COP1 in chronic lymphocytic leukemia cells for promotion of cell proliferation and tumorigenicity.
Fu C, Gong Y, Shi X, Shi H, Wan Y, Wu Q, Xu K. | 10/29/2016 |
| COP1 directly interacts with p27 through a VP motif on p27 and functions as an E3 ligase of p27 to accelerate the ubiquitin-mediated degradation of p27. COP1-p27 axis deregulation is involved in tumorigenesis. | COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth.
Choi HH, Phan L, Chou PC, Su CH, Yeung SC, Chen JS, Lee MH., Free PMC Article | 05/28/2016 |
| COP1 overexpression leads to the cytoplasmic distribution of p27, thereby accelerating p27 degradation. | Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis.
Choi HH, Guma S, Fang L, Phan L, Ivan C, Baggerly K, Sood A, Lee MH., Free PMC Article | 04/23/2016 |
| COP1 negatively regulates ETV1 in patients with triple-negative breast cancer. | COP1, the negative regulator of ETV1, influences prognosis in triple-negative breast cancer.
Ouyang M, Wang H, Ma J, Lü W, Li J, Yao C, Chang G, Bi J, Wang S, Wang W., Free PMC Article | 01/23/2016 |
| changes in the expression of fast-responding early genes is modulated by huCOP1 in keratinocytes upon UVB irradiation | UVB-dependent changes in the expression of fast-responding early genes is modulated by huCOP1 in keratinocytes.
Fazekas B, Polyánka H, Bebes A, Tax G, Szabó K, Farkas K, Kinyó A, Nagy F, Kemény L, Széll M, Ádám É. | 07/25/2015 |