| Upregulation of CD39 During Gout Attacks Promotes Spontaneous Remission of Acute Gouty Inflammation. | Upregulation of CD39 During Gout Attacks Promotes Spontaneous Remission of Acute Gouty Inflammation.
Luo C, Liu X, Liu Y, Shao H, Gao J, Tao J. | 05/9/2024 |
| ADP-mediated Modulation of Intracellular Calcium Responses in Chromaffin Cells: The Role of Ectonucleoside Triphosphate Diphosphohydrolase 2 on Rat Adrenal Medulla Function. | ADP-mediated Modulation of Intracellular Calcium Responses in Chromaffin Cells: The Role of Ectonucleoside Triphosphate Diphosphohydrolase 2 on Rat Adrenal Medulla Function.
Maesawa S, Yokoyama T, Sakanoue W, Yamamoto Y, Hirakawa M, Shiraishi H, Sato K, Saino T., | 01/4/2024 |
| Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under Neuroinflammatory Conditions In Vivo and In Vitro. | Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under Neuroinflammatory Conditions In Vivo and In Vitro.
Dragic M, Mihajlovic K, Adzic M, Jakovljevic M, Kontic MZ, Mitrović N, Laketa D, Lavrnja I, Kipp M, Grković I, Nedeljkovic N., Free PMC Article | 05/28/2022 |
| At the transcriptional level, extracellular ATP upregulated expression of NTPDase1, NTPDase2, NPP2, and eN, while, at translational and functional levels, these were paralleled only by the induction of NTPDase2 and ecto-5'-nucleotidase. | Extracellular ATP Selectively Upregulates Ecto-Nucleoside Triphosphate Diphosphohydrolase 2 and Ecto-5'-Nucleotidase by Rat Cortical Astrocytes In Vitro.
Brisevac D, Adzic M, Laketa D, Parabucki A, Milosevic M, Lavrnja I, Bjelobaba I, Sévigny J, Kipp M, Nedeljkovic N. | 08/13/2016 |
| Apo and complex structures of the rat NTPDase2 extracellular domain and Legionella pneumophila NTPDase1. | Crystallographic snapshots along the reaction pathway of nucleoside triphosphate diphosphohydrolases.
Zebisch M, Krauss M, Schäfer P, Lauble P, Sträter N. | 02/22/2014 |
| two ENTPD isoforms, ENTPD-1 and -2, are expressed in adult rat ventricular CFs | Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts.
Lu D, Insel PA., Free PMC Article | 09/14/2013 |
| NTPDase2 overexpression modulates pro-inflammatory cytokine production and platelet reactivity. | Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury.
Braganhol E, Zanin RF, Bernardi A, Bergamin LS, Cappellari AR, Campesato LF, Morrone FB, Campos MM, Calixto JB, Edelweiss MI, Wink MR, Sévigny J, Robson SC, Battastini AM., Free PMC Article | 07/13/2013 |
| ATP acts in an autocrine manner to promote its own release and that of dopamine, an action that is controlled by the level of E-NTPDase1/CD39 expression | The expression level of ecto-NTP diphosphohydrolase1/CD39 modulates exocytotic and ischemic release of neurotransmitters in a cellular model of sympathetic neurons.
Corti F, Olson KE, Marcus AJ, Levi R., Free PMC Article | 06/25/2011 |
| Modulation of ATP, ADP and AMP hydrolysis suggests that they operate during EAE and might represent the basis of novel therapeutic strategies in immune-mediated diseases, such as MS. | Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis.
Lavrnja I, Bjelobaba I, Stojiljkovic M, Pekovic S, Mostarica-Stojkovic M, Stosic-Grujicic S, Nedeljkovic N. | 01/21/2010 |
| Selective NTPDase2 expression modulates in vivo rat glioma growth. | Selective NTPDase2 expression modulates in vivo rat glioma growth.
Braganhol E, Morrone FB, Bernardi A, Huppes D, Meurer L, Edelweiss MI, Lenz G, Wink MR, Robson SC, Battastini AM., Free PMC Article | 01/21/2010 |
| The structure of the extracellular domain of Rattus norvegicus NTPDase2 in an active state at resolutions between 1.7 A and 2.1 A in four different forms, is presented. | Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling.
Zebisch M, Sträter N., Free PMC Article | 01/21/2010 |
| IL-6 transcriptionally downregulates NTPDase2 expression by portal fibroblasts via actions at specific promoter elements independently of myofibroblastic differentiation | IL-6 downregulates transcription of NTPDase2 via specific promoter elements.
Yu J, Lavoie EG, Sheung N, Tremblay JJ, Sévigny J, Dranoff JA., Free PMC Article | 01/21/2010 |
| Data showed that Entpd2 as the enzyme with the highest expression in left ventricle. | E-NTPDases and ecto-5'-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings.
Rücker B, Almeida ME, Libermann TA, Zerbini LF, Wink MR, Sarkis JJ. | 01/21/2010 |
| NTPDase2 ectodomain refolded from bacterial inclusion bodies was characterized. | Characterization of Rat NTPDase1, -2, and -3 ectodomains refolded from bacterial inclusion bodies.
Zebisch M, Sträter N. | 01/21/2010 |
| NTPdase2 expression profile was studied in the Walker 256 carcinoma. | NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor.
Buffon A, Wink MR, Ribeiro BV, Casali EA, Libermann TA, Zerbini LF, Robson SC, Sarkis JJ. | 01/21/2010 |
| down-regulation in biliary cirrhosis | Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis.
Dranoff JA, Kruglov EA, Toure J, Braun N, Zimmermann H, Jain D, Knowles AF, Sévigny J. | 01/21/2010 |
| hepatic stellate cells differentially regulate nucleoside triphosphate diphosphohydrolase expression after activation | Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells.
Dranoff JA, Ogawa M, Kruglov EA, Gaça MD, Sévigny J, Robson SC, Wells RG., Free PMC Article | 01/21/2010 |
| NTPDase2 is associated with nonmyelinating Schwann cells of the rat sciatic nerve. It was associated with the satellite glial cells in dorsal root ganglia and sympathetic ganglia, and with the enteric ganglion glia. | Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system.
Braun N, Sévigny J, Robson SC, Hammer K, Hanani M, Zimmermann H. | 01/21/2010 |
| NTPDase2 was expressed in the periportal region surrounding intrahepatic bile ducts | The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver.
Dranoff JA, Kruglov EA, Robson SC, Braun N, Zimmermann H, Sévigny J. | 01/21/2010 |
| alternative coding of the intracellular C-terminal domain contributes distinctive phenotypic variation with respect to extracellular nucleotide specificity, hydrolysis kinetics, protein kinase-dependent intracellular regulation and protein trafficking | C-terminal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation.
Wang CJ, Vlajkovic SM, Housley GD, Braun N, Zimmermann H, Robson SC, Sévigny J, Soeller C, Thorne PR., Free PMC Article | 01/21/2010 |
| novel inducible release of full length particulate CD39, and propose its role in the physiological context of pancreatic secretion. | Rat pancreas secretes particulate ecto-nucleotidase CD39.
Sørensen CE, Amstrup J, Rasmussen HN, Ankorina-Stark I, Novak I., Free PMC Article | 01/21/2010 |
| NTPDase2 has a role in portal fibroblast regulation of bile duct epithelium proliferation | Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2.
Jhandier MN, Kruglov EA, Lavoie EG, Sévigny J, Dranoff JA. | 01/21/2010 |
| the amplitude of the long-lasting phase of the Ca(2+) signal depended on the balance between agonist degradation by ectonucleotidases and agonist transport, by diffusion and convection, from bulk solution to the EC surface | The duration and amplitude of the plateau phase of ATP- and ADP-evoked Ca(2+) signals are modulated by ectonucleotidases in in situ endothelial cells of rat aorta.
Berra-Romani R, Rinaldi C, Raqeeb A, Castelli L, Magistretti J, Taglietti V, Tanzi F. | 01/21/2010 |
| NTPDase2 may modulate inflammatory reactions within the central nervous system and could represent a useful therapeutic target in human disease. | Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes.
Wink MR, Braganhol E, Tamajusuku AS, Lenz G, Zerbini LF, Libermann TA, Sévigny J, Battastini AM, Robson SC. | 01/21/2010 |