| The alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression. | The alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression.
Lan C, Zhang H, Wang K, Liu X, Zhao Y, Guo Z, Zhang N, Zhou Y, Gao M, Gu F, Ma Y., Free PMC Article | 10/8/2022 |
| ITSN1: a novel candidate gene involved in autosomal dominant neurodevelopmental disorder spectrum. | ITSN1: a novel candidate gene involved in autosomal dominant neurodevelopmental disorder spectrum.
Bruel AL, Vitobello A, Thiffault I, Manwaring L, Willing M, Agrawal PB, Bayat A, Kitzler TM, Brownstein CA, Genetti CA, Gonzalez-Heydrich J, Jayakar P, Zyskind JW, Zhu Z, Vachet C, Wilson GR, Pruniski B, Goyette AM, Duffourd Y, Thauvin-Robinet C, Philippe C, Faivre L., Free PMC Article | 03/26/2022 |
| Endocytic protein intersectin1-S shuttles into nucleus to suppress the DNA replication in breast cancer. | Endocytic protein intersectin1-S shuttles into nucleus to suppress the DNA replication in breast cancer.
Zhang H, Guo Z, Liu X, Zhao Y, Chen Y, Zhang M, Fu L, Gu F, Ma Y., Free PMC Article | 02/5/2022 |
| ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs. | ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs.
Pankivskyi S, Pastré D, Steiner E, Joshi V, Rynditch A, Hamon L., Free PMC Article | 03/6/2021 |
| two isoforms of intersectin1 ITSN1-S and ITSN1-L produced by alternative splicing exerted opposite functions in glioma development. | Alternative splicing-derived intersectin1-L and intersectin1-S exert opposite function in glioma progression.
Shao Y, Chong W, Liu X, Xu Y, Zhang H, Xu Q, Guo Z, Zhao Y, Zhang M, Ma Y, Gu F., Free PMC Article | 07/11/2020 |
| Different modes of ubiquitination regulated by AIP4 have opposite effects on ITSN1 isoform stability. | Ubiquitin-ligase AIP4 controls differential ubiquitination and stability of isoforms of the scaffold protein ITSN1.
Dergai O, Dergai M, Rynditch A. | 06/29/2019 |
| the long isoform of intersectin-1 (ITSN-1), a guanine nucleotide exchange factor for Cdc42, is identified as a novel Golgi component and an interaction partner of GCC88 responsible for mediating the actin-dependent dispersal of the Golgi ribbon. | Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture.
Makhoul C, Gosavi P, Duffield R, Delbridge B, Williamson NA, Gleeson PA., Free PMC Article | 06/29/2019 |
| WIP enhances the interaction of N-WASP with ITSN1 and promotes ITSN1/beta-actin association. | WIP/ITSN1 complex is involved in cellular vesicle trafficking and formation of filopodia-like protrusions.
Gryaznova T, Gubar O, Burdyniuk M, Kropyvko S, Rynditch A. | 08/25/2018 |
| Here, we discover that intersectin-s binds DENND2B, a guanine nucleotide exchange factor for the exocytic GTPase Rab13, and this interaction promotes recycling of ligand-free EGFR to the cell surface. Our study thus reveals a novel mechanism controlling the fate of internalized EGFR with important implications for cancer. | Intersectin-s interaction with DENND2B facilitates recycling of epidermal growth factor receptor.
Ioannou MS, Kulasekaran G, Fotouhi M, Morein JJ, Han C, Tse S, Nossova N, Han T, Mannard E, McPherson PS., Free PMC Article | 08/4/2018 |
| study reports that vaccinia virus A36 contains three NPF motifs that interact with the Eps15 homology (EH) domains in intersectin-1 and Eps15 to promote the release of virus from infected cells and their subsequent spread | NPF motifs in the vaccinia virus protein A36 recruit intersectin-1 to promote Cdc42:N-WASP-mediated viral release from infected cells.
Snetkov X, Weisswange I, Pfanzelter J, Humphries AC, Way M. | 02/3/2018 |
| Silencing ITSN1 in neuroblastoma cells led to decreased tumor growth in an orthotopic mouse model. Orthotopic animal models can provide insight into the role of ITSN1 pathways in neuroblastoma tumorigenesis. | Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice.
Harris J, Herrero-Garcia E, Russo A, Kajdacsy-Balla A, O'Bryan JP, Chiu B., Free PMC Article | 11/4/2017 |
| These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion. | Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.
Kropyvko S, Gryaznova T, Morderer D, Rynditch A. | 06/10/2017 |
| Abnormal expression of the intersectin1-L protein in epileptic brain tissue may play an important role in epilepsy, especially refractory epilepsy. | Altered Expression of Intersectin1-L in Patients with Refractory Epilepsy and in Experimental Epileptic Rats.
Yang X, Xu X, Zhang Y, Wang S, Li M, Wang X. | 04/23/2016 |
| Study suggests critical roles of ITSN1-S in malignant glioma proliferation, indicating a potential usage of ITSN1-S in the therapeutic intervention as a novel molecular target | Intersectin1-S, a multidomain adapter protein, is essential for malignant glioma proliferation.
Gu F, Zhang H, Qin F, Liu X, Li W, Fu L, Ying G, Li B, Zhang M, Ma Y. | 04/16/2016 |
| Our observations suggest that ITSN1 is an important general regulator of Cdc42-, Nck- and N-WASP-dependent actin polymerisation | Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation.
Humphries AC, Donnelly SK, Way M. | 09/20/2014 |
| ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins. | Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
Novokhatska O, Dergai M, Tsyba L, Skrypkina I, Filonenko V, Moreau J, Rynditch A., Free PMC Article | 03/8/2014 |
| Silencing ITSN1 significantly inhibits the anchorage independent growth of tumor cells in vitro. | Intersectin 1 is required for neuroblastoma tumorigenesis.
Russo A, O'Bryan JP., Free PMC Article | 04/6/2013 |
| the neuron-specific isoform of the stable tubule-only polypeptide (STOP) interacts with SH3A domain of ITSN1. | Endocytic adaptor protein intersectin 1 forms a complex with microtubule stabilizer STOP in neurons.
Morderer D, Nikolaienko O, Skrypkina I, Cherkas V, Tsyba L, Belan P, Rynditch A. | 10/13/2012 |
| ITSN-1s, via its SH3A domain has the unique ability to regulate dyn2 assembly-disassembly and function during endocytosis | Regulation of dynamin-2 assembly-disassembly and function through the SH3A domain of intersectin-1s.
Knezevic I, Predescu D, Bardita C, Wang M, Sharma T, Keith B, Neamu R, Malik AB, Predescu S., Free PMC Article | 04/14/2012 |
| ITSN1 has two isoforms: ITSN1-long and ITSN1-short. siRNA-mediated down regulation of ITSN1-short inhibits migration and invasion of glioma cells. | Intersectin1-s is involved in migration and invasion of human glioma cells.
Ma Y, Wang B, Li W, Liu X, Wang J, Ding T, Zhang J, Ying G, Fu L, Gu F. | 03/31/2012 |
| study reveals a link between overexpression of specific ITSN1 isoforms and behavioral phenotypes | Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.
Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP., Free PMC Article | 01/14/2012 |
| This novel mammalian ITSN1 isoform possesses a significantly altered domain structure and performs specific protein-protein interactions. | Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1.
Dergai M, Skrypkina I, Dergai O, Tsyba L, Novokhatska O, Filonenko V, Drobot L, Rynditch A. | 10/29/2011 |
| Downregulation of intersectin-1s induces apoptosis of brain glioblastoma cells. | Reduction of intersectin1-s induced apoptosis of human glioblastoma cells.
Ma Y, Wang B, Li W, Ying G, Fu L, Niu R, Gu F. | 05/21/2011 |
| Studied the inhibitory mechanism of ITSN1L, & id'd a novel short amino acid motif which mediates autoinhibition. Found this motif is located in the SH3 DH linker region, and show that W1221 acts as key residue in establishing inhibitory interaction. | Autoinhibition of GEF activity in Intersectin 1 is mediated by the short SH3-DH domain linker.
Kintscher C, Wuertenberger S, Eylenstein R, Uhlendorf T, Groemping Y., Free PMC Article | 02/26/2011 |
| These findings expand the role of ITSN1 as a scaffolding molecule bringing together components of endocytic complexes. | Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits.
Dergai O, Novokhatska O, Dergai M, Skrypkina I, Tsyba L, Moreau J, Rynditch A. | 01/1/2011 |