| Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1. | Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1.
Mann G, Sulkshane P, Sadhu P, Ziv T, Glickman MH, Brik A., Free PMC Article | 09/3/2022 |
| Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. | Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.
Liess AKL, Kucerova A, Schweimer K, Schlesinger D, Dybkov O, Urlaub H, Mansfeld J, Lorenz S., Free PMC Article | 10/30/2021 |
| Fibroblast studies showed that the intronic mutation causes the activation of a 95 bp pseudoexon, leading to mRNAs with premature termination codons and nonsense-mediated decay, decreased ANAPC1 protein levels, and prolongation of interphase | Mutations in ANAPC1, Encoding a Scaffold Subunit of the Anaphase-Promoting Complex, Cause Rothmund-Thomson Syndrome Type 1.
Ajeawung NF, Nguyen TTM, Lu L, Kucharski TJ, Rousseau J, Molidperee S, Atienza J, Gamache I, Jin W, Plon SE, Lee BH, Teodoro JG, Wang LL, Campeau PM., Free PMC Article | 04/4/2020 |
| The anaphase promoting complex/cyclosome (APC/C) E3 ligase is not simply an interaction hub, but a dynamic, multifunctional molecular machine whose structure is remodeled by binding partners to achieve temporal ubiquitylation regulating cell division [Review]. | Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.
Watson ER, Brown NG, Peters JM, Stark H, Schulman BA., Free PMC Article | 01/4/2020 |
| Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density. | Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density.
Ivarsdottir EV, Benonisdottir S, Thorleifsson G, Sulem P, Oddsson A, Styrkarsdottir U, Kristmundsdottir S, Arnadottir GA, Thorgeirsson G, Jonsdottir I, Zoega GM, Thorsteinsdottir U, Gudbjartsson DF, Jonasson F, Holm H, Stefansson K., Free PMC Article | 04/6/2019 |
| Data show that FZR1 (Fzr), a cofactor of the multi-subunit E3 ligase complex anaphase-promoting complex/cyclosome (APC/C), represents a therapeutic target in myeloma. | Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myeloma.
Crawford LJ, Anderson G, Johnston CK, Irvine AE., Free PMC Article | 03/3/2018 |
| in the Alzheimer's disease (AD)mouse model APP/PS1, lower cdh1 levels were observed in pyramidal neurons in CA1 when compared to age-matched wildtype mice. In this review, we provide a complete list of APC/C substrates that are involved in the nervous system and we discuss their functions. We also summarize recent studies that show neurobiological effects in cdh1 knockout mouse models. | New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer's Disease.
Fuchsberger T, Lloret A, Viña J., Free PMC Article | 03/3/2018 |
| cryo-EM structure of an APC/C-Cdh1 complex with Apc1(WD40) deleted showed that the mutant APC/C is locked into an inactive conformation in which the UbcH10-binding site of the catalytic module is inaccessible. Additionally, an EM density for Apc15 is not visible | WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.
Li Q, Chang L, Aibara S, Yang J, Zhang Z, Barford D., Free PMC Article | 01/27/2018 |
| The ABBA-KEN-ABBA amino acid motif cassette holds the Mitotic Checkpoint Complex (MCC) onto the Anaphase-Promoting Complex-Cyclosome (APC/C) by binding the two Cdc20 molecules in the MCC-APC/C complex. | The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.
Di Fiore B, Wurzenberger C, Davey NE, Pines J., Free PMC Article | 09/9/2017 |
| findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma. | The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.
Cao J, Dai X, Wan L, Wang H, Zhang J, Goff PS, Sviderskaya EV, Xuan Z, Xu Z, Xu X, Hinds P, Flaherty KT, Faller DV, Goding CR, Wang Y, Wei W, Cui R. | 07/16/2016 |
| Human Cytomegalovirus UL21a but not UL97 can disrupt APC/C function, leading to the accumulation of substrates and that UL21a is necessary and sufficient to induce the degradation of APC1, in addition to the previously reported APC4 and APC5. | Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5.
Clark AE, Spector DH., Free PMC Article | 08/29/2015 |
| Data indicate that regulation of Rad17 turnover is through the Cdh1/anaphase-promoting complex pathway in breast cancer cells. | Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment.
Zhou Z, Jing C, Zhang L, Takeo F, Kim H, Huang Y, Liu Z, Wan Y., Free PMC Article | 09/7/2013 |
| EYA1 is efficiently degraded during mitotic exit in a ANAPC1-dependent manner and these two proteins physically interact. | The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition.
Sun J, Karoulia Z, Wong EY, Ahmed M, Itoh K, Xu PX., Free PMC Article | 04/13/2013 |
| analysis of ubiquitylation of p53 by the APC/C inhibitor Trim39 | Ubiquitylation of p53 by the APC/C inhibitor Trim39.
Zhang L, Huang NJ, Chen C, Tang W, Kornbluth S., Free PMC Article | 03/2/2013 |
| Single nucleotide polymorhpisms of ANAPC1 were associated with nicotine dependence. | ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.
Wang KS, Liu X, Zhang Q, Zeng M. | 12/22/2012 |
| Studies indicate that the APC/C is tightly regulated by its co-activators and by the spindle assembly checkpoint. | Cubism and the cell cycle: the many faces of the APC/C.
Pines J. | 10/1/2011 |
| the ability of Emi1 to inhibit APC/C is negatively regulated by CDKs | Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.
Moshe Y, Bar-On O, Ganoth D, Hershko A., Free PMC Article | 07/16/2011 |
| Data demonstrate that PFKFB3 is essential for cell division and that it is regulated by APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP. | Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle.
Tudzarova S, Colombo SL, Stoeber K, Carcamo S, Williams GH, Moncada S., Free PMC Article | 06/18/2011 |
| These results suggest that APC/C(Cdh1) is involved in ubiquitination and down-regulating the stability of TRB3 protein. | Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3.
Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H. | 03/29/2010 |
| Studies indicate that APC/C(Cdh1) is required to maintain genomic stability. | The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.
Wäsch R, Robbins JA, Cross FR., Free PMC Article | 02/8/2010 |
| ANAPC1 methylation was probably not implicated in gastric carcinogenesis | Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer.
Lima EM, Leal MF, Burbano RR, Khayat AS, Assumpção PP, Bello MJ, Rey JA, Smith MA, Casartelli C. | 01/21/2010 |
| Cdh1 may function as a component in tumor suppression via proteolysis of Skp2 in colorectal tumorigenesis and may serve as a prognostic marker in colon cancer patients. | Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.
Fujita T, Liu W, Doihara H, Wan Y., Free PMC Article | 01/21/2010 |