| Deficiency of SIAH1 promotes the formation of filopodia by increasing the accumulation of FASN in liver cancer. | Deficiency of SIAH1 promotes the formation of filopodia by increasing the accumulation of FASN in liver cancer.
Liu Z, Hu Q, Cao K, Sun J, Cui L, Ji M, Shan W, Yang W, Zhang G, Tian Z, Shi H, Zhang B, Wang R., Free PMC Article | 09/6/2024 |
| SIAH1 Promotes the Pyroptosis of Cardiomyocytes in Diabetic Cardiomyopathy via Regulating IkappaB-alpha/NF-kappacapital VE, Cyrillic Signaling. | SIAH1 Promotes the Pyroptosis of Cardiomyocytes in Diabetic Cardiomyopathy via Regulating IκB-α/NF-κВ Signaling.
Wu J, Yan Y. | 06/14/2024 |
| FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1. | FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1.
Wang Y, Wang K, Fu J, Zhang Y, Mao Y, Wang X, Wang X, Yu R, Zhou X., Free PMC Article | 12/10/2022 |
| Siah1 promotes the proliferation of NSCLC cells through ubiquitinating and stabilizing Notch1. | Siah1 promotes the proliferation of NSCLC cells through ubiquitinating and stabilizing Notch1.
Liu Y, Li Q, Geng L, Zhou X, Zhou X, Dong Y, Zhang Y. | 09/10/2022 |
| SIAH1 promotes senescence and apoptosis of nucleus pulposus cells to exacerbate disc degeneration through ubiquitinating XIAP. | SIAH1 promotes senescence and apoptosis of nucleus pulposus cells to exacerbate disc degeneration through ubiquitinating XIAP.
Fang S, Zeng F, Chen R, Li M. | 06/11/2022 |
| Reactive oxygen species-induced SIAH1 promotes granulosa cells' senescence in premature ovarian failure. | Reactive oxygen species-induced SIAH1 promotes granulosa cells' senescence in premature ovarian failure.
Lin L, Gao W, Chen Y, Li T, Sha C, Chen L, Yang M, Wei H, Chen Y, Zhu X., Free PMC Article | 04/23/2022 |
| Proteasomal activator 28 gamma stabilizes hepatitis B virus X protein by competitively inhibiting the Siah-1-mediated proteasomal degradation. | Proteasomal activator 28 gamma stabilizes hepatitis B virus X protein by competitively inhibiting the Siah-1-mediated proteasomal degradation.
Han J, Kim H, Jeong H, Yoon H, Jang KL. | 01/29/2022 |
| miR-129-5p Ameliorates Ischemic Brain Injury by Binding to SIAH1 and Activating the mTOR Signaling Pathway. | miR-129-5p Ameliorates Ischemic Brain Injury by Binding to SIAH1 and Activating the mTOR Signaling Pathway.
Lei Y, Jin X, Sun M, Ji Z. | 01/22/2022 |
| Siah1 in cancer and nervous system diseases (Review). | Siah1 in cancer and nervous system diseases (Review).
Zhang H, Wang J, Ge Y, Ye M, Jin X. | 01/15/2022 |
| Hepatitis C virus core protein inhibits hepatitis B virus replication by downregulating HBx levels via Siah-1-mediated proteasomal degradation during coinfection. | Hepatitis C virus core protein inhibits hepatitis B virus replication by downregulating HBx levels via Siah-1-mediated proteasomal degradation during coinfection.
Lee S, Yoon H, Han J, Jang KL. | 12/25/2021 |
| De novo variants in SIAH1, encoding an E3 ubiquitin ligase, are associated with developmental delay, hypotonia and dysmorphic features. | De novo variants in SIAH1, encoding an E3 ubiquitin ligase, are associated with developmental delay, hypotonia and dysmorphic features.
Buratti J, Ji L, Keren B, Lee Y, Booke S, Erdin S, Kim SY, Palculict TB, Meiner V, Chae JH, Woods CG, Tam A, Héron D, Cong F, Harel T. | 09/4/2021 |
| TRAF4, a new substrate of SIAH1, participates in chemotherapy resistance of breast cancer cell by counteracting SIAH1-mediated downregulation of beta-catenin. | TRAF4, a new substrate of SIAH1, participates in chemotherapy resistance of breast cancer cell by counteracting SIAH1-mediated downregulation of β-catenin.
Ren H, Mi X, Zhao P, Zhao X, Wei N, Huang H, Meng Z, Kou J, Sun M, Liu Y, Zhang H, Yang J, Li W, Li H. | 01/9/2021 |
| Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2. | Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2.
Wu J, Xue Y, Gao X, Zhou Q., Free PMC Article | 09/19/2020 |
| Depletion of Siah1 enhanced Akt3 levels in the soma and axonal tips, eliciting multiple branching. | SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development.
Ko HR, Jin EJ, Lee SB, Kim CK, Yun T, Cho SW, Park KW, Ahn JY., Free PMC Article | 06/27/2020 |
| PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/beta-catenin axis. | PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis.
Deng Q, Hou J, Feng L, Lv A, Ke X, Liang H, Wang F, Zhang K, Chen K, Cui H., Free PMC Article | 12/14/2019 |
| Data suggest that lncRNA small nucleolar RNA host gene 1, as a pathogenic factor, promotes alpha-synuclein aggregation and toxicity by targeting the miR-15b-5p/seven in absentia homolog 1 axis. | LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells.
Chen Y, Lian YJ, Ma YQ, Wu CJ, Zheng YK, Xie NC. | 03/23/2019 |
| Results show that abolishing ICP0:SIAH-1 interaction affects the HSV-2 phenotype during infection. In vitro, the SIAH-binding deficient mutant synthesized significantly less DNA and protein, and virus growth was clearly attenuated compared to wild-type virus. In model mice, HSV-2 carrying the SIAH-binding deficient mutation caused an acute infection in the murine eye and was able to spread to the innervating neurons. | Interaction between the cellular E3 ubiquitin ligase SIAH-1 and the viral immediate-early protein ICP0 enables efficient replication of Herpes Simplex Virus type 2 in vivo.
Czechowicz JS, Nagel CH, Voges M, Spohn M, Eibl MM, Hauber J., Free PMC Article | 02/2/2019 |
| Using the novel PUM1 and PUM2 mRNA target SIAH1 as a model, this study shows mechanistic differences between PUM1 and PUM2 and between NANOS1, 2, and 3 paralogues in the regulation of SIAH1. | PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues.
Sajek M, Janecki DM, Smialek MJ, Ginter-Matuszewska B, Spik A, Oczkowski S, Ilaslan E, Kusz-Zamelczyk K, Kotecki M, Blazewicz J, Jaruzelska J., Free PMC Article | 01/26/2019 |
| Depletion of KDM3A coincided with the loss of SIAH1 induction and the accumulation of dimethylated H3K9 surrounding the SIAH1 promoter. Interestingly, KDM3A expression was also up-regulated by nutritional stress in a HIF-1alpha dependent manner. | HIF-1α coordinates epigenetic activation of SIAH1 in hepatocytes in response to nutritional stress.
Fan Z, Li Z, Yang Y, Liu S, Guo J, Xu Y. | 12/23/2017 |
| The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways. | The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear.
Zhang Q, Wang Z, Hou F, Harding R, Huang X, Dong A, Walker JR, Tong Y. | 11/4/2017 |
| Results showed that SIAH1 and PTP4A1 expression was regulated by mir-944 in breast cancer cells. miR-944 binds directly the 3 UTR of their promotor region. | Suppression of cell migration is promoted by miR-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells.
Flores-Pérez A, Marchat LA, Rodríguez-Cuevas S, Bautista VP, Fuentes-Mera L, Romero-Zamora D, Maciel-Dominguez A, de la Cruz OH, Fonseca-Sánchez M, Ruíz-García E, la Vega HA, López-Camarillo C., Free PMC Article | 10/21/2017 |
| Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt-induced Axin degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin through interacting with a VxP motif in the GSK3-binding domain of Axin, and this function of SIAH is counteracted by GSK3 binding to Axin. | The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.
Ji L, Jiang B, Jiang X, Charlat O, Chen A, Mickanin C, Bauer A, Xu W, Yan X, Cong F., Free PMC Article | 09/23/2017 |
| results suggest that CacyBP/SIP is involved in regulation of the Hsp90 chaperone machinery | Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone.
Góral A, Bieganowski P, Prus W, Krzemień-Ojak Ł, Kądziołka B, Fabczak H, Filipek A., Free PMC Article | 07/22/2017 |
| PINK1 disease mutants failed to recruit synphilin-1 and did not activate mitophagy, indicating that PINK1-synphilin-1-SIAH-1 represents a new parkin-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease. | The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway.
Szargel R, Shani V, Abd Elghani F, Mekies LN, Liani E, Rott R, Engelender S. | 07/15/2017 |
| Results suggest that activated STAT3 regulates active beta-catenin protein levels via stabilization of SIAH-1 and the subsequent ubiquitin-dependent proteasomal degradation of beta-catenin in HEK293T cells. | STAT3 Potentiates SIAH-1 Mediated Proteasomal Degradation of β-Catenin in Human Embryonic Kidney Cells.
Shin M, Yi EH, Kim BH, Shin JC, Park JY, Cho CH, Park JW, Choi KY, Ye SK., Free PMC Article | 04/29/2017 |