| Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2. | Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.
Dong W, Li Q, Lu X, Lan J, Qiu Z, Wang X, Wang J, Zheng X, Chen S, Zhang C, Jin J., Free PMC Article | 05/1/2024 |
| Ceramide kinase confers tamoxifen resistance in estrogen receptor-positive breast cancer by altering sphingolipid metabolism. | Ceramide kinase confers tamoxifen resistance in estrogen receptor-positive breast cancer by altering sphingolipid metabolism.
Huang C, Su L, Chen Y, Wu S, Sun R, Xu Q, Qiu X, Yang C, Kong X, Qin H, Zhao X, Jiang X, Wang K, Zhu Y, Wong PP. | 02/15/2023 |
| Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance. | Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance.
Bhadwal P, Randhawa V, Vaiphei K, Dahiya D, Agnihotri N., Free PMC Article | 11/12/2022 |
| Ceramide kinase regulates TNF-alpha-induced immune responses in human monocytic cells. | Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells.
Al-Rashed F, Ahmad Z, Snider AJ, Thomas R, Kochumon S, Melhem M, Sindhu S, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R., Free PMC Article | 11/27/2021 |
| MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle. | MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.
Kukreti H, Amuthavalli K. | 07/10/2021 |
| Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt. | Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt.
Schwalm S, Erhardt M, Römer I, Pfeilschifter J, Zangemeister-Wittke U, Huwiler A., Free PMC Article | 01/9/2021 |
| Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells. | Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells.
Tomizawa S, Tamori M, Tanaka A, Utsumi N, Sato H, Hatakeyama H, Hisaka A, Kohama T, Yamagata K, Honda T, Nakamura H, Murayama T. | 10/31/2020 |
| an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5 | Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.
Newcomb B, Rhein C, Mileva I, Ahmad R, Clarke CJ, Snider J, Obeid LM, Hannun YA., Free PMC Article | 08/24/2019 |
| Our study expands the genotypic spectra of CERKL variants, providing insights into the relevant pathogenesis of RP/CRD | Novel CERKL variant in consanguineous Jordanian pedigrees with inherited retinal dystrophies.
Azab B, Barham R, Ali D, Dardas Z, Rashdan L, Bijawi M, Maswadi R, Awidi A, Jafar H, Abu-Ameerh M, Al-Bdour M, Amr S, Awidi A. | 07/27/2019 |
| results suggest that intracellular ceramide kinase is required for the migration of bone marrow-derived mesenchymal stem cells, and the roles of the intrinsic ceramide kinase in the migration are associated with N-cadherin regulation | Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells.
Yu J, Kim HM, Kim KP, Son Y, Kim MS, Park KS. | 06/8/2019 |
| our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway. | Ceramide kinase promotes tumor cell survival and mammary tumor recurrence.
Payne AW, Pant DK, Pan TC, Chodosh LA., Free PMC Article | 01/10/2015 |
| Data suggest that inhibition of ceramide kinase (CerK) [by specific gene silencing or pharmacological inhibition] drastically reduced cell proliferation in a neuroblastoma cell line. | New signalling pathway involved in the anti-proliferative action of vitamin D₃ and its analogues in human neuroblastoma cells. A role for ceramide kinase.
Bini F, Frati A, Garcia-Gil M, Battistini C, Granado M, Martinesi M, Mainardi M, Vannini E, Luzzati F, Caleo M, Peretto P, Gomez-Muñoz A, Meacci E. | 12/8/2012 |
| TNF-alpha exposure of human SH-SY5Y neuroblastoma caused a profound increase in CERK activity. | Ceramide kinase regulates TNFα-stimulated NADPH oxidase activity and eicosanoid biosynthesis in neuroblastoma cells.
Barth BM, Gustafson SJ, Hankins JL, Kaiser JM, Haakenson JK, Kester M, Kuhn TB., Free PMC Article | 07/28/2012 |
| Expression of hCERK enhanced ceramide-1-phosphate formation and release of arachidonic acid in Ca(2+) ionophore-stimulated cells. | Role of cytosolic phospholipase A(2)α in cell rounding and cytotoxicity induced by ceramide-1-phosphate via ceramide kinase.
Nakamura H, Tada E, Makiyama T, Yasufuku K, Murayama T. | 09/17/2011 |
| We have identified a differential role for ceramide kinase in mast-cell activation | A differential role for ceramide kinase in antigen/FcɛRI-mediated mast cell activation and function.
Hewson CA, Watson JR, Liu WL, Fidock MD. | 05/28/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2 | JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2.
Gubern A, Barceló-Torns M, Barneda D, López JM, Masgrau R, Picatoste F, Chalfant CE, Balsinde J, Balboa MA, Claro E., Free PMC Article | 01/21/2010 |
| ceramide kinase, was associated with poor pathohistological grading in breast cancer | Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.
Ruckhäberle E, Karn T, Rody A, Hanker L, Gätje R, Metzler D, Holtrich U, Kaufmann M. | 01/21/2010 |
| The Pleckstrin Homology (PH) domain of CERK, which is required for Golgi complex localization, can substitute for the N-terminal region of CERKL and allow for wild-type CERKL localization, which is typified by nucleolar accumulation. | Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains.
Rovina P, Schanzer A, Graf C, Mechtcheriakova D, Jaritz M, Bornancin F. | 01/21/2010 |
| identification of a cluster of cysteines, C(347)XXXC(351)XXC(354), essential for CerK function | A conserved cysteine motif essential for ceramide kinase function.
Lidome E, Graf C, Jaritz M, Schanzer A, Rovina P, Nikolay R, Bornancin F. | 01/21/2010 |
| higher Ca2+ signal observed in hCERK transfected cells as well as the fact that CERK colocalized with EIgG during phagocytosis support hypothesis that Ca2+ signaling is an important factor for increasing phagocytosis and is regulated by CERK | Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells.
Hinkovska-Galcheva V, Clark A, VanWay S, Huang JB, Hiraoka M, Abe A, Borofsky M, Kunkel RG, Shanley T, Shayman JA, Lanni F, Petty HR, Boxer LA. | 01/21/2010 |
| HL-60 cells are useful for studying CerK functions in leukocyte differentiation, and they also suggest that CerK might have an important role in such differentiation. | Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60.
Date T, Mitsutake S, Igarashi Y. | 01/21/2010 |
| Results demonstrate that CERK localizes to areas of eicosanoid synthesis and uses a ceramide "pool" transported in an active manner via CERT. | Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.
Lamour NF, Stahelin RV, Wijesinghe DS, Maceyka M, Wang E, Allegood JC, Merrill AH Jr, Cho W, Chalfant CE. | 01/21/2010 |
| These results suggest that ceramide kinase determines the balance between pro-apoptotic ceramide and anti-apoptotic C1P to regulate cell fate, reminiscent of its function in plants. | Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells.
Mitra P, Maceyka M, Payne SG, Lamour N, Milstien S, Chalfant CE, Spiegel S. | 01/21/2010 |
| Recombinant CERK was analyzed with regard to dependence on divalent cations, to substrate delivery, specificity, and stereoselectivity. CERK associated with the plasma membrane in CHO cells, which is mediated by the N-terminal putative pleckstrin domain. | Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.
Van Overloop H, Gijsbers S, Van Veldhoven PP. | 01/21/2010 |