| ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility. | ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility.
Costa AF, Senra E, Faria-Ramos I, Teixeira A, Morais J, Pacheco M, Reis CA, Gomes C., Free PMC Article | 07/19/2023 |
| Role of a Disease-associated ST3Gal-4 in Non-small Cell Lung Cancer. | Role of a Disease-associated ST3Gal-4 in Non-small Cell Lung Cancer.
Singh P, Joon A, Kumari M, Singh T, Bal A, Maan P, Ghosh S. | 10/22/2022 |
| MiR-193b modulates osteoarthritis progression through targeting ST3GAL4 via sialylation of CD44 and NF-small ka, CyrillicB pathway. | MiR-193b modulates osteoarthritis progression through targeting ST3GAL4 via sialylation of CD44 and NF-кB pathway.
Wang T, Hao Z, Liu C, Yuan L, Li L, Yin M, Li Q, Qi Z, Wang Z. | 12/4/2021 |
| Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation. | Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation.
Kitano M, Kizuka Y, Sobajima T, Nakano M, Nakajima K, Misaki R, Itoyama S, Harada Y, Harada A, Miyoshi E, Taniguchi N., Free PMC Article | 08/28/2021 |
| Identification and characterization of the V3 promoter of the ST3GAL4 gene. | Identification and characterization of the V3 promoter of the ST3GAL4 gene.
Martínez-Morales PL, Ortiz-Mateos CA, Reyes-Pineda J, Reyes-Vallejo T, Aguilar-Lemarroy A, Jave-Suárez LF, Santos-López G, Reyes-Leyva J, Milflores-Flores L, Vallejo-Ruiz V. | 03/20/2021 |
| a cross-restoration of each of the three genes in ST3GAL6 KO cells showed that overexpression of ST3GAL6 sufficiently rescued the total alpha2,3-sialylation levels, cell morphology, and alpha2,3-sialylation of EGFR, whereas the alpha2,3-sialylation levels of beta1 were greatly enhanced by an overexpression of ST3GAL4 | ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins.
Qi F, Isaji T, Duan C, Yang J, Wang Y, Fukuda T, Gu J. | 07/11/2020 |
| MiR-193a-3p and miR-224 promoted the cell proliferation and decreased apoptosis by targeting alpha-2,3-sialyltransferase IV in renal cell carcinoma. | MiR-193a-3p and miR-224 mediate renal cell carcinoma progression by targeting alpha-2,3-sialyltransferase IV and the phosphatidylinositol 3 kinase/Akt pathway.
Pan Y, Hu J, Ma J, Qi X, Zhou H, Miao X, Zheng W, Jia L. | 03/30/2019 |
| The V1 transcript of the ST3GAL4 demonstrated significant decreased expression in premalignant and malignant cervical tissues. | Expression analysis of ST3GAL4 transcripts in cervical cancer cells.
Roa-de La Cruz L, Martínez-Morales P, Morán-Cruz I, Milflores-Flores L, Rosas-Murrieta N, González-Ramírez C, Ortiz-Mateos C, Monterrosas-Santamaría R, González-Frías C, Rodea-Ávila C, Apresa-García T, Aguilar-Lemarroy A, Jave-Suarez L, Santos-López G, Reyes-Leyva J, Vallejo-Ruiz V. | 11/17/2018 |
| study illustrates the power of next-generation sequencing in the discovery of new genetic variants and a significant ethnic diversity in the ST3GAL4 gene | Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity.
Song J, Xue C, Preisser JS, Cramer DW, Houck KL, Liu G, Folsom AR, Couper D, Yu F, Dong JF., Free PMC Article | 08/5/2017 |
| ST3GAL IV affects apoptotic signal, cell proliferation and the effectiveness of imatinib treatment in chronic myeloid leukemia cells. | Downregulation of miR-224 and let-7i contribute to cell survival and chemoresistance in chronic myeloid leukemia cells by regulating ST3GAL IV expression.
Zhou H, Li Y, Liu B, Shan Y, Li Y, Zhao L, Su Z, Jia L. | 07/29/2017 |
| TNF-responsive element in an intronic region of the ST3GAL4 gene, whose TNF-dependent activity is repressed by ERK/p38 and MSK1/2 inhibitors. This TNF-responsive element contains potential binding sites for ETS1 and ATF2 transcription factors related to TNF signaling. | TNF up-regulates ST3GAL4 and sialyl-Lewisx expression in lung epithelial cells through an intronic ATF2-responsive element.
Colomb F, Krzewinski-Recchi MA, Steenackers A, Vincent A, Harduin-Lepers A, Delannoy P, Groux-Degroote S. | 06/10/2017 |
| Expression levels of sialyltransferases ST3GAL1 and ST3GAL4 were upregulated in the HRMECs after high-glucose stimulation. | Alteration of N-Glycan Profiles in Diabetic Retinopathy.
Inafuku S, Noda K, Amano M, Ohashi T, Yoshizawa C, Saito W, Murata M, Kanda A, Nishimura S, Ishida S. | 10/31/2015 |
| There may be a racial/ethnic-specific association, and/or sex-specific association between the ST3GAL4 rs11220462 SNP and serum lipid parameters in some ethnic groups. | Association of the ST3GAL4 rs11220462 polymorphism and serum lipid levels in the Mulao and Han populations.
Lin QZ, Yin RX, Guo T, Wu J, Sun JQ, Shen SW, Shi GY, Wu JZ, Liu CW, Pan SL., Free PMC Article | 04/4/2015 |
| ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes | ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes.
Mondal N, Buffone A Jr, Stolfa G, Antonopoulos A, Lau JT, Haslam SM, Dell A, Neelamegham S., Free PMC Article | 03/28/2015 |
| The polymorphism analysis showed that at SNP rs10893506, genotypes CC and CT of the ST3GAL4 B3 promoter were associated with the presence of premalignant lesions and cervical cancer. | Promoter polymorphisms of ST3GAL4 and ST6GAL1 genes and associations with risk of premalignant and malignant lesions of the cervix.
Rivera-Juarez Mde L, Rosas-Murrieta NH, Mendieta-Carmona V, Hernandez-Pacheco RE, Zamora-Ginez I, Rodea-Avila C, Apresa-Garcia T, Garay-Villar O, Aguilar-Lemarroy A, Jave-Suarez LF, Diaz-Orea MA, Milflores-Flores L, Reyes-Salinas JS, Ceja-Utrera FJ, Vazquez-Zamora VJ, Vargas-Maldonado T, Reyes-Carmona S, Sosa-Jurado F, Santos-Lopez G, Reyes-Leyva J, Vallejo-Ruiz V. | 11/22/2014 |
| the role of ST3Gal IV in the acquisition of adhesive, migratory and metastatic capabilities and, secondly, in analyzing the expression of ST3Gal III and ST3Gal IV in pancreatic adenocarcinoma tissues, was investigated. | α2,3-Sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues.
Pérez-Garay M, Arteta B, Llop E, Cobler L, Pagès L, Ortiz R, Ferri MJ, de Bolós C, Figueras J, de Llorens R, Vidal-Vanaclocha F, Peracaula R. | 02/15/2014 |
| The expression of ST3GAL4 leads to SLe(x) antigen expression in gastric cancer cells which in turn induces an increased invasive phenotype through the activation of c-Met | Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
Gomes C, Osório H, Pinto MT, Campos D, Oliveira MJ, Reis CA., Free PMC Article | 02/1/2014 |
| TNF increases the expression of alpha2,3-sialyltransferase gene ST3GAL4 | TNF regulates sialyl-Lewisx and 6-sulfo-sialyl-Lewisx expression in human lung through up-regulation of ST3GAL4 transcript isoform BX.
Colomb F, Krzewinski-Recchi MA, El Machhour F, Mensier E, Jaillard S, Steenackers A, Harduin-Lepers A, Lafitte JJ, Delannoy P, Groux-Degroote S. | 11/24/2012 |
| These results indicated that gastric cancer tissues expressed high levels of alpha 2,3-linked sialic acid residues, ST3Gal IV, and ST6Gal I. | Altered mRNA expressions of sialyltransferases in human gastric cancer tissues.
Jun L, Yuanshu W, Yanying X, Zhongfa X, Jian Y, Fengling W, Xianjun Q, Kokudo N, Wei T, Weixia Z, Shuxiang C. | 08/25/2012 |
| These data suggest that the ST3GAL4 gene is responsible for biosynthesis of the viral receptor and may play a crucial role in infection of H5N1 avian influenza virus in humans. | Inhibition of H5N1 highly pathogenic influenza virus by suppressing a specific sialyltransferase.
Monteerarat Y, Suptawiwat O, Boonarkart C, Uiprasertkul M, Auewarakul P, Viprakasit V. | 07/12/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| Expression of ST3Gal IV in several gastrointestinal cell lines is correlated with the expression of sialyl Lewis x at the cell surface. | Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.
Carvalho AS, Harduin-Lepers A, Magalhães A, Machado E, Mendes N, Costa LT, Matthiesen R, Almeida R, Costa J, Reis CA. | 03/1/2010 |
| Thrombocytopenia in mice deficient in the St3gal4 sialyltransferase gene (St3Gal-IV(-/-) mice) is caused by the recognition of terminal galactose residues exposed on the platelet surface in the absence of sialylation. | Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.
Sørensen AL, Rumjantseva V, Nayeb-Hashemi S, Clausen H, Hartwig JH, Wandall HH, Hoffmeister KM., Free PMC Article | 01/21/2010 |
| down-regulation of ST3Gal IV mRNA may be one of the factors associated with the malignant progression of human renal cell carcinoma. | Clinical significance of ST3Gal IV expression in human renal cell carcinoma.
Saito S, Yamashita S, Endoh M, Yamato T, Hoshi S, Ohyama C, Watanabe R, Ito A, Satoh M, Wada T, Paulson JC, Arai Y, Miyagi T. | 01/21/2010 |