DNA-PK controls Apollo's access to leading-end telomeres. | DNA-PK controls Apollo's access to leading-end telomeres. Sonmez C, Toia B, Eickhoff P, Matei AM, El Beyrouthy M, Wallner B, Douglas ME, de Lange T, Lottersberger F., Free PMC Article | 05/30/2024 |
DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection. | DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection. Bories C, Lejour T, Adolphe F, Kermasson L, Couvé S, Tanguy L, Luszczewska G, Watzky M, Poillerat V, Garnier P, Groisman R, Ferlicot S, Richard S, Saparbaev M, Revy P, Gad S, Renaud F. | 05/6/2024 |
DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer. | DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer. Li L, Wang F, Deng Z, Zhang G, Zhu L, Zhao Z, Liu R., Free PMC Article | 11/14/2023 |
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Yosaatmadja Y, Baddock HT, Newman JA, Bielinski M, Gavard AE, Mukhopadhyay SMM, Dannerfjord AA, Schofield CJ, McHugh PJ, Gileadi O., Free PMC Article | 11/6/2021 |
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family. | A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family. Baddock HT, Newman JA, Yosaatmadja Y, Bielinski M, Schofield CJ, Gileadi O, McHugh PJ., Free PMC Article | 11/6/2021 |
Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A and SNM1B. | The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities. Allerston CK, Lee SY, Newman JA, Schofield CJ, McHugh PJ, Gileadi O., Free PMC Article | 06/28/2016 |
The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability. | The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability. Mason JM, Das I, Arlt M, Patel N, Kraftson S, Glover TW, Sekiguchi JM., Free PMC Article | 07/26/2014 |
the N-terminal region of Snm1B forms a complex containing PSF2 and Mus81, while the C-terminal region is important for PSF2-mediated chromatin association. | Snm1B interacts with PSF2. Stringer JR, Counter CM., Free PMC Article | 05/18/2013 |
The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4. | The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4. Salewsky B, Schmiester M, Schindler D, Digweed M, Demuth I. | 03/30/2013 |
differences in the substrate selectivities of SNM1A and SNM1B are likely to be relevant to their in vivo roles | Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. Sengerová B, Allerston CK, Abu M, Lee SY, Hartley J, Kiakos K, Schofield CJ, Hartley JA, Gileadi O, McHugh PJ., Free PMC Article | 10/13/2012 |
SNM1B functions epistatically to the central Fanconi anemia factor, FANCD2, in cellular survival after interstrand crosslinks damage and homology-directed repair of DNA double-strand breaks | Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks. Mason JM, Sekiguchi JM., Free PMC Article | 10/22/2011 |
TRF2, which binds preferentially to positively supercoiled DNA substrates, together with Apollo, negatively regulates the amount of TOP1, TOP2alpha, and TOP2beta at telomeres. | TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Ye J, Lenain C, Bauwens S, Rizzo A, Saint-Léger A, Poulet A, Benarroch D, Magdinier F, Morere J, Amiard S, Verhoeyen E, Britton S, Calsou P, Salles B, Bizard A, Nadal M, Salvati E, Sabatier L, Wu Y, Biroccio A, Londoño-Vallejo A, Giraud-Panis MJ, Gilson E. | 08/23/2010 |
DCLRE1B protein binds to a C-terminal fragment of HSP72 Heat-Shock Proteins, known to contain the substrate binding domain. | Evidence for hSNM1B/Apollo functioning in the HSP70 mediated DNA damage response. Anders M, Mattow J, Digweed M, Demuth I. | 01/21/2010 |
Results suggest that SNM1B/Apollo and Astrin function together to enforce the prophase checkpoint in response to spindle stress. | SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint. Liu L, Akhter S, Bae JB, Mukhopadhyay SS, Richie CT, Liu X, Legerski R. | 01/21/2010 |
observations suggest an important role for hSNM1B in the response to ionizing radiation damage, a role that may be, in part, upstream of the central player in maintenance of genome integrity, ATM | Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation. Demuth I, Bradshaw PS, Lindner A, Anders M, Heinrich S, Kallenbach J, Schmelz K, Digweed M, Meyn MS, Concannon P., Free PMC Article | 01/21/2010 |
The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2 | The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2. Freibaum BD, Counter CM., Free PMC Article | 01/21/2010 |
Snm1B interacts with the Mre11-Rad50-Nbs1 (MRN) complex and with FancD2 further substantiating its role as a checkpoint/DNA repair protein. | Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Bae JB, Mukhopadhyay SS, Liu L, Zhang N, Tan J, Akhter S, Liu X, Shen X, Li L, Legerski RJ., Free PMC Article | 01/21/2010 |
siRNA knockdown of hSNM1B rendered cells sensitive to ionizing radiation, suggesting the possibility of hSNM1B involvement in homologous recombination repair of double-strand breaks arising as intermediates of ICL repair | Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation. Demuth I, Digweed M, Concannon P. | 01/21/2010 |
the C terminus of Snm1B was shown to interact with the TRF homology domain of TRF2 indicating that Snm1B is likely recruited to the telomere via interaction with the double-stranded telomere-binding protein TRF2 | hSnm1B is a novel telomere-associated protein. Freibaum BD, Counter CM. | 01/21/2010 |
SNM1B (Apollo) is an Artemis-like nuclease that is required for the protection of telomeres during or after their replication. [Apollo] | Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. van Overbeek M, de Lange T. | 01/21/2010 |
SNM1B (Apollo) protein exhibits a 5'-to-3' DNA exonuclease activity and functions together with TRF2 to protect telomeres from damage and fusion. | The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. Lenain C, Bauwens S, Amiard S, Brunori M, Giraud-Panis MJ, Gilson E. | 01/21/2010 |