| Functional AGXT2 SNP rs180749 variant and depressive symptoms: Baseline data from the Aidai Cohort Study in Japan. | Functional AGXT2 SNP rs180749 variant and depressive symptoms: Baseline data from the Aidai Cohort Study in Japan.
Kumon H, Miyake Y, Yoshino Y, Iga JI, Tanaka K, Senba H, Kimura E, Higaki T, Matsuura B, Kawamoto R, Ueno SI., Free PMC Article | 02/23/2024 |
| Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment. | Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment.
Granot-Hershkovitz E, Spitzer B, Yang Y, Tarraf W, Yu B, Boerwinkle E, Fornage M, Mosley TH, DeCarli C, Kristal BS, González HM, Sofer T., Free PMC Article | 05/15/2023 |
| Functional AGXT2 SNP rs37369 Variant Is a Risk Factor for Diabetes Mellitus: Baseline Data From the Aidai Cohort Study in Japan. | Functional AGXT2 SNP rs37369 Variant Is a Risk Factor for Diabetes Mellitus: Baseline Data From the Aidai Cohort Study in Japan.
Kumon H, Miyake Y, Yoshino Y, Iga JI, Tanaka K, Senba H, Kimura E, Higaki T, Matsuura B, Kawamoto R, Ueno SI. | 01/11/2023 |
| Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in non-alcoholic fatty liver disease. | Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in non-alcoholic fatty liver disease.
Yoo T, Joo SK, Kim HJ, Kim HY, Sim H, Lee J, Kim HH, Jung S, Lee Y, Jamialahmadi O, Romeo S, Jeong WI, Hwang GS, Kang KW, Kim JW, Kim W, Choi M, Innovative Target Exploration of NAFLD (ITEN) consortium. | 02/12/2022 |
| The role of alanine glyoxylate transaminase-2 (agxt2) in beta-alanine and carnosine metabolism of healthy mice and humans. | The role of alanine glyoxylate transaminase-2 (agxt2) in β-alanine and carnosine metabolism of healthy mice and humans.
Stautemas J, Jarzebska N, Shan ZX, Blancquaert L, Everaert I, de Jager S, De Baere S, Hautekiet A, Volkaert A, Lefevere FBD, Martens-Lobenhoffer J, Bode-Böger SM, Kim CK, Leiper J, Weiss N, Croubels S, Rodionov RN, Derave W. | 08/21/2021 |
| Effects of AGXT2 variants on blood pressure and blood sugar among 750 older Japanese subjects recruited by the complete enumeration survey method. | Effects of AGXT2 variants on blood pressure and blood sugar among 750 older Japanese subjects recruited by the complete enumeration survey method.
Yoshino Y, Kumon H, Mori T, Yoshida T, Tachibana A, Shimizu H, Iga JI, Ueno SI., Free PMC Article | 06/26/2021 |
| Alanine-Glyoxylate Aminotransferase 2 (AGTX2)-dependent pathway is a relatively recently discovered alternative pathway of dimethylarginine catabolism and its role on Rheumatoid Arthritis -related atherosclerotic disease is yet to be established. Gene variants of AGTX-2 may influence dimethylarginine levels in Rheumatoid Arthritis patients and provide the rationale for larger studies in this field. | Genetic regulation of dimethylarginines and endothelial dysfunction in rheumatoid arthritis.
Dimitroulas T, Kitas GD. | 12/28/2019 |
| Carriers of AGXT2 rs37369-T allele (CT + TT genotypes) and AGXT2 rs16899974-A allele (CA + AA genotypes) had 2.4- and 2.08-fold higher risk of having coronary artery disease than CC genotype in both SNPs (p = 0.0050 and 0.0192, respectively). AGXT2 rs37369 TT and AGXT2 rs16899974 AA genotypes were associated with the highest serum ADMA and SDMA | AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians.
Amir M, Hassanein SI, Abdel Rahman MF, Gad MZ. | 04/27/2019 |
| We purified human AGXT2 from tissues of AGXT2 transgenic mice and demonstrated its ability to metabolize homoarginine to 6-guanidino-2-oxocaproic acid (GOCA). After incubation of HepG2 cells overexpressing AGXT2 with isotope-labeled homoarginine-d4 we were able to detect labeled GOCA in the medium | A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine:glyoxylate aminotransferase 2.
Rodionov RN, Oppici E, Martens-Lobenhoffer J, Jarzebska N, Brilloff S, Burdin D, Demyanov A, Kolouschek A, Leiper J, Maas R, Cellini B, Weiss N, Bode-Böger SM., Free PMC Article | 05/12/2018 |
| study in a well-characterized rheumatoid arthritis population did not show an association between serum concentrations of dimethylarginines and genetic variants of the AGXT2 gene. | Genetic variations in the alanine-glyoxylate aminotransferase 2 (AGXT2) gene and dimethylarginines levels in rheumatoid arthritis.
Dimitroulas T, Hodson J, Panoulas VF, Sandoo A, Smith J, Kitas G. | 02/24/2018 |
| AGXT2 rs37369 polymorphism is associated with increased risk for chronic heart failure, which may due to distinct disparities of alleles in asymmetric dimethylarginine degradation | Considerable impacts of AGXT2 V140I polymorphism on chronic heart failure in the Chinese population.
Hu XL, Zhou JP, Kuang DB, Qi H, Peng LM, Yang TL, Li X, Zhang W, Zhou HH, Chen XP. | 12/30/2017 |
| Single nucleotide polymorphism in AGXT2 gene is associated with renal dysfunction in patients with chronic heart failure. | AGXT2 rs37369 polymorphism predicts the renal function in patients with chronic heart failure.
Hu XL, Zeng WJ, Li MP, Yang YL, Kuang DB, Li H, Zhang YJ, Jiang C, Peng LM, Qi H, Zhang K, Chen XP. | 12/16/2017 |
| The Alanine-glyoxylate aminotransferase 2 p.V498L polymorphism is associated with both paroxysmal and chronic forms of atrial fibrillation in coronary angiographic patients without structural heart disease in ultrasound, and earlier age at onset of ischemic stroke in patients undergoing exercise stress testing. | Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke.
Seppälä I, Kleber ME, Bevan S, Lyytikäinen LP, Oksala N, Hernesniemi JA, Mäkelä KM, Rothwell PM, Sudlow C, Dichgans M, Mononen N, Vlachopoulou E, Sinisalo J, Delgado GE, Laaksonen R, Koskinen T, Scharnagl H, Kähönen M, Markus HS, März W, Lehtimäki T., Free PMC Article | 02/25/2017 |
| AGXT2 rs37369 polymorphism is associated with increased risk for CHD in smokers and in diabetes mellitus patients | Association of the AGXT2 V140I polymorphism with risk for coronary heart disease in a Chinese population.
Zhou JP, Bai YP, Hu XL, Kuang DB, Shi RZ, Xiong Y, Zhang W, Xia J, Chen BL, Yang TL, Chen XP. | 07/4/2015 |
| The AGXT2 genotype may be an important factor underlying atherosclerosis. | Missense variants of the alanine: glyoxylate aminotransferase 2 gene correlated with carotid atherosclerosis in the Japanese population.
Yoshino Y, Kohara K, Abe M, Ochi S, Mori Y, Yamashita K, Igase M, Tabara Y, Mori T, Miki T, Ueno S. | 03/28/2015 |
| The results of this study that the AGXT2 gene is not associated with schizophrenia in Japanese subjects. | Missense variants of the alanine:glyoxylate aminotransferase 2 gene are not associated with Japanese schizophrenia patients.
Yoshino Y, Abe M, Numata S, Ochi S, Mori Y, Ishimaru T, Kinoshita M, Umehara H, Yamazaki K, Mori T, Ohmori T, Ueno S. | 01/24/2015 |
| SNPs of AGXT2 affect plasma as well as urinary BAIB. | Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and β-aminoisobutyrate metabolism in healthy volunteers.
Kittel A, Müller F, König J, Mieth M, Sticht H, Zolk O, Kralj A, Heinrich MR, Fromm MF, Maas R., Free PMC Article | 12/27/2014 |
| AGXT2 has an important role in SDMA metabolism in humans and may additionally have an unanticipated role in the autonomic nervous system regulation of cardiac function. | Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
Seppälä I, Kleber ME, Lyytikäinen LP, Hernesniemi JA, Mäkelä KM, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kähönen N, Alfthan G, Viikari JS, Kähonen M, Raitakari OT, März W, Meinitzer A, Lehtimäki T, AtheroRemo Consortium. | 11/8/2014 |
| Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. | Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure.
Caplin B, Wang Z, Slaviero A, Tomlinson J, Dowsett L, Delahaye M, Salama A, International Consortium for Blood Pressure Genome-Wide Association Studies, Wheeler DC, Leiper J. | 02/2/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| mitochondrially localized human AGXT2 is able to effectively metabolize ADMA in vivo resulting in decreased ADMA levels and improved endothelial NO production. | Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production.
Rodionov RN, Murry DJ, Vaulman SF, Stevens JW, Lentz SR., Free PMC Article | 03/15/2010 |
| Discusses the cloning of the rat gene. | Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney.
Lee IS, Muragaki Y, Ideguchi T, Hase T, Tsuji M, Ooshima A, Okuno E, Kido R. | 04/8/2003 |