| Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal cardiomyopathy. | Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal cardiomyopathy.
Lieberwirth JK, Joset P, Heinze A, Hentschel J, Stein A, Iannaccone A, Steindl K, Kuechler A, Abou Jamra R., Free PMC Article | 01/22/2022 |
| There was a significant increase in protein levels of ZnT5 in the prefrontal cortex in Major depression disorder, relative to control subjects. | Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims.
Rafalo-Ulinska A, Piotrowska J, Kryczyk A, Opoka W, Sowa-Kucma M, Misztak P, Rajkowska G, Stockmeier CA, Datka W, Nowak G, Szewczyk B., Free PMC Article | 09/23/2017 |
| Overexpression of ZnT5 is accompanied by activation of PI3K/Akt pathway and inhibiting HG-induced apoptosis. | Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis.
Zhang X, Liang D, Guo B, Deng W, Chi ZH, Cai Y, Wang L, Ma J. | 09/21/2013 |
| Results identify a unique class of transporters Znt5 and Znt8 and the structural motif required to discriminate between Zn(2+) and Cd(2+) transport. | Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.
Hoch E, Lin W, Chai J, Hershfinkel M, Fu D, Sekler I., Free PMC Article | 08/18/2012 |
| exons 15 to 17 include a signal that results in trafficking of ZnT5 to the Golgi apparatus and that the 3' end of exon 14 includes a signal that leads to retention in the ER. | Differential subcellular localization of the splice variants of the zinc transporter ZnT5 is dictated by the different C-terminal regions.
Thornton JK, Taylor KM, Ford D, Valentine RA., Free PMC Article | 02/25/2012 |
| The cytosolic C-terminal tail of ZnT5 is important for its interaction with ZnT6 as a heterodimer. | Demonstration and characterization of the heterodimerization of ZnT5 and ZnT6 in the early secretory pathway.
Fukunaka A, Suzuki T, Kurokawa Y, Yamazaki T, Fujiwara N, Ishihara K, Migaki H, Okumura K, Masuda S, Yamaguchi-Iwai Y, Nagao M, Kambe T., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
Wang X, Chorley BN, Pittman GS, Kleeberger SR, Brothers J 2nd, Liu G, Spira A, Bell DA. Polymorphisms in mitochondrial genes and prostate cancer risk.
Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN. | 09/20/2009 |
| Data show that ZNT5 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. | Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain.
Zhang LH, Wang X, Stoltenberg M, Danscher G, Huang L, Wang ZY. | 01/21/2010 |
| hZnT-5 is up-regulated in response to cellular zinc depletion in Raji cells. | Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.
Overbeck S, Uciechowski P, Ackland ML, Ford D, Rink L. | 01/21/2010 |
| A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane | A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane.
Cragg RA, Christie GR, Phillips SR, Russi RM, Küry S, Mathers JC, Taylor PM, Ford D. | 01/21/2010 |
| cloning and characterization of ZnT-5 which is expressed in pancreatic beta cells | Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.
Kambe T, Narita H, Yamaguchi-Iwai Y, Hirose J, Amano T, Sugiura N, Sasaki R, Mori K, Iwanaga T, Nagao M. | 01/21/2010 |