| DNMT1-mediated regulating on FBXO32 promotes the progression of glioma cells through the regulation of SKP1 activity. | DNMT1-mediated regulating on FBXO32 promotes the progression of glioma cells through the regulation of SKP1 activity.
Quan J, Ma C. | 01/11/2024 |
| A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion. | A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion.
Li J, Krause GJ, Gui Q, Kaushik S, Rona G, Zhang Q, Liang FX, Dhabaria A, Anerillas C, Martindale JL, Vasilyev N, Askenazi M, Ueberheide B, Nudler E, Gorospe M, Cuervo AM, Pagano M., Free PMC Article | 11/7/2023 |
| The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei. | The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei.
Rashpa R, Klages N, Schvartz D, Pasquarello C, Brochet M., Free PMC Article | 03/29/2023 |
| A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members. | A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members.
Campos Gudiño R, Farrell AC, Neudorf NM, McManus KJ., Free PMC Article | 02/5/2022 |
| Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer. | Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer.
Lepage CC, Palmer MCL, Farrell AC, Neudorf NM, Lichtensztejn Z, Nachtigal MW, McManus KJ., Free PMC Article | 12/18/2021 |
| Long non-coding RNA CCDC183-AS1 acts AS a miR-589-5p sponge to promote the progression of hepatocellular carcinoma through regulating SKP1 expression. | Long non-coding RNA CCDC183-AS1 acts AS a miR-589-5p sponge to promote the progression of hepatocellular carcinoma through regulating SKP1 expression.
Zhu H, Zhang H, Pei Y, Liao Z, Liu F, Su C, Liu Y, Dong R, Song J, Zhang X, Fan Y, Liang H, Zhang B, Chen X., Free PMC Article | 10/16/2021 |
| Skp1 Dimerization Conceals Its F-Box Protein Binding Site. | Skp1 Dimerization Conceals Its F-Box Protein Binding Site.
Kim HW, Eletsky A, Gonzalez KJ, van der Wel H, Strauch EM, Prestegard JH, West CM., Free PMC Article | 12/26/2020 |
| High SKP1 expression is associated with Lung Adenocarcinogenesis. | Stratifin Inhibits SCF(FBW7) Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis.
Shiba-Ishii A, Hong J, Hirokawa T, Kim Y, Nakagawa T, Sakashita S, Sakamoto N, Kozuma Y, Sato Y, Noguchi M. | 06/20/2020 |
| a novel role for SKP1 as an auxiliary component of the target recognition module that enhances binding of FBXO45 to NMNAT2. | PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2.
Desbois M, Crawley O, Evans PR, Baker ST, Masuho I, Yasuda R, Grill B., Free PMC Article | 03/2/2019 |
| Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family | Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.
Karolak JA, Gambin T, Pitarque JA, Molinari A, Jhangiani S, Stankiewicz P, Lupski JR, Gajecka M., Free PMC Article | 07/29/2017 |
| Both the F-box domain of Skp2 and Skp1-Skp2 domain motions displaying preferential conformational control can together facilitate polyubiquitination of a wide variety of substrates. | Molecular dynamics simulations elucidate the mode of protein recognition by Skp1 and the F-box domain in the SCF complex.
Chandra Dantu S, Nathubhai Kachariya N, Kumar A. | 10/22/2016 |
| Skp1 is critical to lung cancer pathogenesis | Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors.
Liu YQ, Wang XL, Cheng X, Lu YZ, Wang GZ, Li XC, Zhang J, Wen ZS, Huang ZL, Gao QL, Yang LN, Cheng YX, Tao SC, Liu J, Zhou GB., Free PMC Article | 09/3/2016 |
| Data show that epithelial-mesenchymal transition (EMT)-transcription factors can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbxo45). | Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors.
Xu M, Zhu C, Zhao X, Chen C, Zhang H, Yuan H, Deng R, Dou J, Wang Y, Huang J, Chen Q, Jiang B, Yu J., Free PMC Article | 11/28/2015 |
| We discuss how these results can explain the rapid association of Cdc34 and Skp1-cullin-F-box ligase (SCF). | Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.
Sandoval D, Hill S, Ziemba A, Lewis S, Kuhlman B, Kleiger G., Free PMC Article | 04/25/2015 |
| SKP1 variation modifies association between Parkinson's disease and ubiquitin-proteasome system-inhibiting pesticides | Pesticides that inhibit the ubiquitin-proteasome system: effect measure modification by genetic variation in SKP1 in Parkinson׳s disease.
Rhodes SL, Fitzmaurice AG, Cockburn M, Bronstein JM, Sinsheimer JS, Ritz B., Free PMC Article | 08/16/2014 |
| Studies indicate that in SCFs, Rbx1 serves as the RING-containing enzyme, Cul1 is the Cullin scaffold, and Skp1 is an adaptor, which serves to link the beta-TrCP F-box substrate-specific factor to the rest of the ligase. | SCFs in the new millennium.
Lee EK, Diehl JA. | 06/28/2014 |
| Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. | Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Yumimoto K, Muneoka T, Tsuboi T, Nakayama KI., Free PMC Article | 01/25/2014 |
| Skp1-Cul1-F-box ubiquitin ligase (SCF(betaTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry | Skp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry.
Burrows AC, Prokop J, Summers MK., Free PMC Article | 02/2/2013 |
| Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism. | Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.
Emberley ED, Mosadeghi R, Deshaies RJ., Free PMC Article | 11/24/2012 |
| we determined that the phage-encoded GogB effector protein in Salmonella targets the host SCF E3 type ubiquitin ligase through an interaction with Skp1 and the human F-box only 22 (FBXO22) protein | GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1.
Pilar AV, Reid-Yu SA, Cooper CA, Mulder DT, Coombes BK., Free PMC Article | 11/17/2012 |
| This review suggested that SKP1 decreased in in sporadic Parkinson's disease. | Targeting SKP1, an ubiquitin E3 ligase component found decreased in sporadic Parkinson's disease.
Mandel SA, Fishman-Jacob T, Youdim MB. | 09/1/2012 |
| phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner | APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1.
Klitzing Cv, Huss R, Illert AL, Fröschl A, Wötzel S, Peschel C, Bassermann F, Duyster J., Free PMC Article | 04/28/2012 |
| SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein | The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein.
Van Rechem C, Black JC, Abbas T, Allen A, Rinehart CA, Yuan GC, Dutta A, Whetstine JR., Free PMC Article | 10/29/2011 |
| These observations suggest that Skp1 plays an important role in stabilizing the conformation of these F-box proteins, which increases their expression levels and substrate-binding. | Skp1 stabilizes the conformation of F-box proteins.
Yoshida Y, Murakami A, Tanaka K. | 09/3/2011 |
| Skp1 binding prevented Fbxo7 from contacting CRM1. | A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins.
Nelson DE, Laman H., Free PMC Article | 08/6/2011 |