| miR-23a-3p promotes the development of colon cancer by inhibiting the expression of NDRG4. | miR-23a-3p promotes the development of colon cancer by inhibiting the expression of NDRG4.
Zuo H, Liu S, Li X, Hou G. | 03/24/2023 |
| Errate: Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis. | Errate: Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis.
Yang Z, Cheng H, Zhang Y, Zhou Y., Free PMC Article | 08/6/2022 |
| Highly sensitive fecal DNA testing of NDRG4 12b methylation is a promising marker for detection of colorectal precancerosis. | Highly sensitive fecal DNA testing of NDRG4 12b methylation is a promising marker for detection of colorectal precancerosis.
Ji X, Sha J, Qian H, Zhang G, He T, Dang Y. | 02/12/2022 |
| A loss-of-function mutation p.T256M in NDRG4 is implicated in the pathogenesis of pulmonary atresia with ventricular septal defect (PA/VSD) and tetralogy of Fallot (TOF). | A loss-of-function mutation p.T256M in NDRG4 is implicated in the pathogenesis of pulmonary atresia with ventricular septal defect (PA/VSD) and tetralogy of Fallot (TOF).
Peng J, Wang Q, Meng Z, Wang J, Zhou Y, Zhou S, Song W, Chen S, Chen AF, Sun K., Free PMC Article | 12/18/2021 |
| MiR-433 Regulates Myocardial Ischemia Reperfusion Injury by Targeting NDRG4 Via the PI3K/Akt Pathway. | MiR-433 Regulates Myocardial Ischemia Reperfusion Injury by Targeting NDRG4 Via the PI3K/Akt Pathway.
Cheng H, Yan W. | 10/9/2021 |
| Hypermethylation-mediated silencing of NDRG4 promotes pancreatic ductal adenocarcinoma by regulating mitochondrial function. | Hypermethylation-mediated silencing of NDRG4 promotes pancreatic ductal adenocarcinoma by regulating mitochondrial function.
Shi HH, Liu HE, Luo XJ., Free PMC Article | 08/28/2021 |
| Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2. | Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2.
Vaes N, Schonkeren SL, Rademakers G, Holland AM, Koch A, Gijbels MJ, Keulers TG, de Wit M, Moonen L, Van der Meer JRM, van den Boezem E, Wolfs TGAM, Threadgill DW, Demmers J, Fijneman RJA, Jimenez CR, Vanden Berghe P, Smits KM, Rouschop KMA, Boesmans W, Hofstra RMW, Melotte V., Free PMC Article | 08/21/2021 |
| TFPI2 and NDRG4 gene promoter methylation analysis in peripheral blood mononuclear cells are novel epigenetic noninvasive biomarkers for colorectal cancer diagnosis. | TFPI2 and NDRG4 gene promoter methylation analysis in peripheral blood mononuclear cells are novel epigenetic noninvasive biomarkers for colorectal cancer diagnosis.
Bagheri H, Mosallaei M, Bagherpour B, Khosravi S, Salehi AR, Salehi R. | 08/7/2021 |
| Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis. | Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis.
Yang Z, Cheng H, Zhang Y, Zhou Y., Free PMC Article | 06/12/2021 |
| NDRG4 Alleviates Abeta1-40 Induction of SH-SY5Y Cell Injury via Activation of BDNF-Inducing Signalling Pathways. | NDRG4 Alleviates Aβ1-40 Induction of SH-SY5Y Cell Injury via Activation of BDNF-Inducing Signalling Pathways.
Kang T, Qu Q, Xie Z, Cao B. | 04/3/2021 |
| Results indicate that NDRG family member 4 protein (NDRG4) could be a potential tumor suppressor and prognostic marker of gastric cancer. | NDRG4 in gastric cancer determines tumor cell proliferation and clinical outcome.
Zhang Z, She J, Yang J, Bu X, Ji G, Zhu S, He S, Chu D. | 03/2/2019 |
| NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein | NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons.
Vaes N, Lentjes MHFM, Gijbels MJ, Rademakers G, Daenen KL, Boesmans W, Wouters KAD, Geuzens A, Qu X, Steinbusch HPJ, Rutten BPF, Baldwin SH, Sharkey KA, Hofstra RMW, van Engeland M, Vanden Berghe P, Melotte V. | 05/12/2018 |
| NDRG4 promoter hypermethylation contributed to the risk of gastric cancer and predicted a poor prognosis in Chinese gastric cancer patients. | NDRG4 hypermethylation is a potential biomarker for diagnosis and prognosis of gastric cancer in Chinese population.
Chen X, Yang Y, Liu J, Li B, Xu Y, Li C, Xu Q, Liu G, Chen Y, Ying J, Duan S., Free PMC Article | 03/3/2018 |
| NDRG4 might play an important role during early pregnancy. | Uterine Expression of NDRG4 Is Induced by Estrogen and Up-Regulated during Embryo Implantation Process in Mice.
Yang Q, Gu Y, Zhang X, Wang JM, He YP, Shi Y, Sun ZG, Shi HJ, Wang J., Free PMC Article | 07/15/2017 |
| NDRG4 - the biomarker of a currently in-use multi-target stool DNA test was commonly expressed in tumor tissue specimens, independent of Fecal Immunochemical Test result. | Genetic Biomarker Prevalence Is Similar in Fecal Immunochemical Test Positive and Negative Colorectal Cancer Tissue.
Levin TR, Corley DA, Jensen CD, Marks AR, Zhao WK, Zebrowski AM, Quinn VP, Browne LW, Taylor WR, Ahlquist DA, Lidgard GP, Berger BM., Free PMC Article | 07/15/2017 |
| Data indicate that patients with tumor of reduced NDRG family member 4 protein (NDRG4) mRNA level had unfavorable disease-free and overall survival. | NDRG4 stratifies the prognostic value of body mass index in colorectal cancer.
Zheng J, Li Y, Zhu S, Li J, Zhao Q, Ji G, Wang W, Chu D., Free PMC Article | 12/17/2016 |
| Study shows that NDRG4 was significantly up-regulated in glioblastomas (GBM) and seems to play a role in GBM prognosis. These results indicate that NDRG4 gene in MGMT-methylated cells is a putative tumor-suppressor gene and an oncogene in cells with unmethylated MGMT. | NDRG2 and NDRG4 Expression Is Altered in Glioblastoma and Influences Survival in Patients with MGMT-methylated Tumors.
Kolodziej MA, Weischer C, Reinges MH, Uhl E, Weigand MA, Schwarm FP, Schänzer A, Acker T, Quint K, Uhle F, Stein M. | 11/19/2016 |
| These findings bring novel insight to the roles of NDRG4 in meningioma progression | NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells.
Kotipatruni RP, Ren X, Thotala D, Jaboin JJ., Free PMC Article | 05/21/2016 |
| Two downregulated genes, NDRG4 and GINS3, have been located in a genomic interval associated with cardiac repolarization in published GWASs and zebra fish knockout models | Adipose tissue gene expression and metabolic health of obese adults.
Das SK, Ma L, Sharma NK., Free PMC Article | 03/26/2016 |
| A homozygous variant in NDRG4 may be the causative variant of the autosomal recessive form of infantile myofibromatosis. | Exome sequencing identifies a novel homozygous variant in NDRG4 in a family with infantile myofibromatosis.
Linhares ND, Freire MC, Cardenas RG, Pena HB, Bahia M, Pena SD. | 07/25/2015 |
| Methylation level in stool decreases dramatically following colorectal cancer resection | Stool methylated DNA markers decrease following colorectal cancer resection--implications for surveillance.
Kisiel JB, Yab TC, Taylor WR, Mahoney DW, Ahlquist DA., Free PMC Article | 10/11/2014 |
| summarizes the current research on NDRG3 and NDRG4,including the molecular structure, cellular and tissue distribution, biological function, and function in cancer. | NDRG3 and NDRG4, two novel tumor-related genes.
Yang X, An L, Li X. | 05/24/2014 |
| expression of NDRG4 is downregulated in human gliomas. The glioma patients with lower NDRG4 expression have a poor prognosis. | Downregulation of N-Myc downstream-regulated gene 4 influences patient survival in gliomas.
Li S, Yang B, Li G, He S, Li Y. | 07/20/2013 |
| NDRG4 is involved in modulating cell proliferation, invasion, migration and angiogenesis in meningioma, and may play a valuable role as a molecular target in its treatment | NDRG4, the N-Myc downstream regulated gene, is important for cell survival, tumor invasion and angiogenesis in meningiomas.
Kotipatruni RP, Ferraro DJ, Ren X, Vanderwaal RP, Thotala DK, Hallahan DE, Jaboin JJ. | 02/16/2013 |
| Over expression of NDRG4 inhibited proliferation of GBM cells. | NDRG4 is downregulated in glioblastoma and inhibits cell proliferation.
Ding W, Zhang J, Yoon JG, Shi D, Foltz G, Lin B., Free PMC Article | 09/15/2012 |