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    PINK1 PTEN induced kinase 1 [ Homo sapiens (human) ]

    Gene ID: 65018, updated on 27-Aug-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis.

    Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis.
    Zhao L, Chen Y, Li H, Ding X, Li J., Free PMC Article

    08/7/2024
    Sgt1 Regulates alpha-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, PINK1 and PARK9.

    Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, PINK1 and PARK9.
    Bohush A, Góral A, Sierant M, Nawrot B, Leśniak W, Filipek A., Free PMC Article

    07/29/2024
    PINK1/Park2-Mediated Mitophagy Relieve Non-Alcoholic Fatty Liver Disease.

    PINK1/Park2-Mediated Mitophagy Relieve Non-Alcoholic Fatty Liver Disease.
    He H, Tang Y, Zhuang L, Zheng Y, Huang X., Free PMC Article

    06/1/2024
    Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy.

    Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy.
    Ji H, Zhao Y, Ma X, Wu L, Guo F, Huang F, Song Y, Wang J, Qin G.

    05/31/2024
    The SCF-FBW7beta E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1.

    The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1.
    Jeon SJ, Chung KC., Free PMC Article

    05/24/2024
    PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway.

    PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway.
    Zheng F, Zhong J, Chen K, Shi Y, Wang F, Wang S, Tang S, Yuan X, Shen Z, Tang S, Xia D, Wu Y, Lu W., Free PMC Article

    03/15/2024
    METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy.

    METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy.
    Wang F, Bai J, Zhang X, Wang D, Zhang X, Xue J, Chen H, Wang S, Chi B, Li J, Ma X., Free PMC Article

    03/13/2024
    PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome.

    PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome.
    Wang K, Zhou Z, Huang L, Kan Q, Wang Z, Wu W, Yao C.

    02/16/2024
    PINK1-mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages.

    PINK1-mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages.
    Jiang K, Li J, Jiang L, Li H, Lei L.

    01/30/2024
    [Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy].

    [Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy].
    Wang YW, Jia KG, Xing HJ, Pan Y, Zeng CS, Chen L, Su QJ, Shen WT, Chen J, Chen C, Cao Q, Wang YY.

    01/5/2024
    Role of Pink1-mediated mitophagy in adenomyosis.

    Role of Pink1-mediated mitophagy in adenomyosis.
    Chen M, Wang W, Fu X, Yi Y, Wang K, Wang M., Free PMC Article

    12/6/2023
    Mitochondria-Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1-PD or PRKN-PD Neurons.

    Mitochondria-Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1-PD or PRKN-PD Neurons.
    Grossmann D, Malburg N, Glaß H, Weeren V, Sondermann V, Pfeiffer JF, Petters J, Lukas J, Seibler P, Klein C, Grünewald A, Hermann A.

    11/1/2023
    AI molecular property prediction for Parkinson's Disease reveals potential repurposing drug candidates based on the increase of the expression of PINK1.

    AI molecular property prediction for Parkinson's Disease reveals potential repurposing drug candidates based on the increase of the expression of PINK1.
    Haneczok J, Delijewski M, Moldzio R.

    09/11/2023
    Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.

    Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.
    Hou X, Chen TH, Koga S, Bredenberg JM, Faroqi AH, Delenclos M, Bu G, Wszolek ZK, Carr JA, Ross OA, McLean PJ, Murray ME, Dickson DW, Fiesel FC, Springer W., Free PMC Article

    08/31/2023
    PINK1 and oxidative stress in lean and obese patients with type 2 diabetes mellitus.

    PINK1 and oxidative stress in lean and obese patients with type 2 diabetes mellitus.
    Almeida EA, Mehndiratta M, Madhu SV, Kar R, Puri D.

    08/4/2023
    Intrafamilial and interfamilial heterogeneity of PINK1-associated Parkinson's disease in Sudan.

    Intrafamilial and interfamilial heterogeneity of PINK1-associated Parkinson's disease in Sudan.
    Bakhit Y, Ibrahim MO, Tesson C, Elhassan AA, Ahmed MA, Alebeed MA, Elrasheed SM, Omar MA, Abubaker R, Eltom K, Shaheen MT, Ibrahim YA, Almak ME, Ali HA, Abugrain AA, Almahal MA, MohamedSharif AA, Tahir MY, Malik SM, Eldirdiri Abdelrahman H, Khidir RJ, Mohamed MT, Abdalla A, Elsayed LEO, Lesage S, Corvol JC, Seidi O, Wüllner U.

    06/15/2023
    Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.

    Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.
    Fiesel FC, Fričová D, Hayes CS, Coban MA, Hudec R, Bredenberg JM, Broadway BJ, Markham BN, Yan T, Boneski PK, Fiorino G, Watzlawik JO, Hou X, McCarty AM, Lewis-Tuffin LJ, Zhong J, Madden BJ, Ordureau A, An H, Puschmann A, Wszolek ZK, Ross OA, Harper JW, Caulfield TR, Springer W., Free PMC Article

    06/14/2023
    RHOA, a small G-protein, signals to mitophagy through regulation of PINK1 protein stability and protects cardiomyocytes against ischemia.

    RHOA, a small G-protein, signals to mitophagy through regulation of PINK1 protein stability and protects cardiomyocytes against ischemia.
    Tu M, Miyamoto S., Free PMC Article

    06/14/2023
    PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool.

    PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool.
    Chen B, Das NK, Talukder I, Singhal R, Castillo C, Andren A, Mancias JD, Lyssiotis CA, Shah YM., Free PMC Article

    06/13/2023
    PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models.

    PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models.
    Han R, Liu Y, Li S, Li XJ, Yang W., Free PMC Article

    06/5/2023
    MicroRNA-593-5p contributes to cell death following exposure to 1-methyl-4-phenylpyridinium by targeting PTEN-induced putative kinase 1.

    MicroRNA-593-5p contributes to cell death following exposure to 1-methyl-4-phenylpyridinium by targeting PTEN-induced putative kinase 1.
    Yoo M, Choi DC, Murphy A, Ahsan AM, Junn E., Free PMC Article

    06/2/2023
    Inhibition of PINK1-Mediated Mitophagy Contributes to Postoperative Cognitive Dysfunction through Activation of Caspase-3/GSDME-Dependent Pyroptosis.

    Inhibition of PINK1-Mediated Mitophagy Contributes to Postoperative Cognitive Dysfunction through Activation of Caspase-3/GSDME-Dependent Pyroptosis.
    Wang W, Zhao B, Gao W, Song W, Hou J, Zhang L, Xia Z.

    04/7/2023
    Mitochondrial ROS driven by NOX4 upregulation promotes hepatocellular carcinoma cell survival after incomplete radiofrequency ablation by inducing of mitophagy via Nrf2/PINK1.

    Mitochondrial ROS driven by NOX4 upregulation promotes hepatocellular carcinoma cell survival after incomplete radiofrequency ablation by inducing of mitophagy via Nrf2/PINK1.
    Peng C, Li X, Ao F, Li T, Guo J, Liu J, Zhang X, Gu J, Mao J, Zhou B., Free PMC Article

    03/28/2023
    Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria.

    Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria.
    Xie XQ, Yang Y, Wang Q, Liu HF, Fang XY, Li CL, Jiang YZ, Wang S, Zhao HY, Miao JY, Ding SS, Liu XD, Yao XH, Yang WT, Jiang J, Shao ZM, Jin G, Bian XW., Free PMC Article

    03/7/2023
    PINK1 regulates apoptosis of osteosarcoma as the target gene of cisplatin.

    PINK1 regulates apoptosis of osteosarcoma as the target gene of cisplatin.
    Si Z, Shen Z, Luan F, Yan J., Free PMC Article

    02/27/2023
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