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    SLC5A3 solute carrier family 5 member 3 [ Homo sapiens (human) ]

    Gene ID: 6526, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    SLC5A3 is important for cervical cancer cell growth.

    SLC5A3 is important for cervical cancer cell growth.
    Li L, Shen FR, Cheng Q, Sun J, Li H, Sun HT, Cai X, Chen M, Yang B, Wang L, Xu L., Free PMC Article

    08/28/2023
    The sodium/myo-inositol co-transporter SLC5A3 promotes non-small cell lung cancer cell growth.

    The sodium/myo-inositol co-transporter SLC5A3 promotes non-small cell lung cancer cell growth.
    Cui Z, Mu C, Wu Z, Pan S, Cheng Z, Zhang ZQ, Zhao J, Xu C., Free PMC Article

    07/2/2022
    Myo-Inositol Transporter SLC5A3 Associates with Degenerative Changes and Inflammation in Sporadic Inclusion Body Myositis.

    Myo-Inositol Transporter SLC5A3 Associates with Degenerative Changes and Inflammation in Sporadic Inclusion Body Myositis.
    De Paepe B, Merckx C, Jarošová J, Cannizzaro M, De Bleecker JL., Free PMC Article

    04/3/2021
    Results show that SMIT1 is expressed in the heart. SMIT1 is able to detect increased extracellular glucose levels and triggers signaling leading to NOX2 activation and ROS production.

    Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart.
    Van Steenbergen A, Balteau M, Ginion A, Ferté L, Battault S, Ravenstein CM, Balligand JL, Daskalopoulos EP, Gilon P, Despa F, Despa S, Vanoverschelde JL, Horman S, Koepsell H, Berry G, Hue L, Bertrand L, Beauloye C., Free PMC Article

    10/27/2018
    SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore

    SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.
    Manville RW, Neverisky DL, Abbott GW., Free PMC Article

    09/2/2017
    overexpression of the Na(+)/myo-inositol cotransporter (SMIT1) and myo-inositol supplementation enlarged intracellular PI(4,5)P2 pools, modulated several PI(4,5)P2-dependent ion channels including KCNQ2/3 channels, and attenuated the action potential firing of superior cervical ganglion neurons

    Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels.
    Dai G, Yu H, Kruse M, Traynor-Kaplan A, Hille B., Free PMC Article

    01/28/2017
    Hypotonic stress causes a significant upregulation of SLC5A3 gene expression as detected by semiquantitative RT-PCR and Western blot analysis.

    Hypotonic activation of the myo-inositol transporter SLC5A3 in HEK293 cells probed by cell volumetry, confocal and super-resolution microscopy.
    Andronic J, Shirakashi R, Pickel SU, Westerling KM, Klein T, Holm T, Sauer M, Sukhorukov VL., Free PMC Article

    01/16/2016
    A kinetic model has been generated for the transport mechanism of SMIT2 allowing insight into the transport of members of the LeuT structural family at the millisecond timescale.

    The transport mechanism of the human sodium/myo-inositol transporter 2 (SMIT2/SGLT6), a member of the LeuT structural family.
    Sasseville LJ, Longpré JP, Wallendorff B, Lapointe JY., Free PMC Article

    10/25/2014
    JAK2 contributes to the regulation of the myoinositol transporter SMIT.

    Down-regulation of the myoinositol transporter SMIT by JAK2.
    Hosseinzadeh Z, Bhavsar SK, Lang F.

    06/1/2013
    Observational study of gene-disease association. (HuGE Navigator)

    A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.
    Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Sharma A, Guiducci C, Perola M, Jula A, Sinisalo J, Lokki ML, Nieminen MS, Melander O, Salomaa V, Peltonen L, Kathiresan S., Free PMC Article

    12/5/2010
    Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

    Additive effect of multiple genetic variants on the risk of coronary artery disease.
    Lluís-Ganella C, Lucas G, Subirana I, Sentí M, Jimenez-Conde J, Marrugat J, Tomás M, Elosua R.

    12/5/2010
    Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

    Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
    Myocardial Infarction Genetics Consortium, Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H, Erdmann J, Reilly MP, Rader DJ, Morgan T, Spertus JA, Stoll M, Girelli D, McKeown PP, Patterson CC, Siscovick DS, O'Donnell CJ, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Melander O, Altshuler D, Ardissino D, Merlini PA, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, Celli P, Ferrario M, Fetiveau R, Marziliano N, Casari G, Galli M, Ribichini F, Rossi M, Bernardi F, Zonzin P, Piazza A, Mannucci PM, Schwartz SM, Siscovick DS, Yee J, Friedlander Y, Elosua R, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Kathiresan S, Meigs JB, Williams G, Nathan DM, MacRae CA, O'Donnell CJ, Salomaa V, Havulinna AS, Peltonen L, Melander O, Berglund G, Voight BF, Kathiresan S, Hirschhorn JN, Asselta R, Duga S, Spreafico M, Musunuru K, Daly MJ, Purcell S, Voight BF, Purcell S, Nemesh J, Korn JM, McCarroll SA, Schwartz SM, Yee J, Kathiresan S, Lucas G, Subirana I, Elosua R, Surti A, Guiducci C, Gianniny L, Mirel D, Parkin M, Burtt N, Gabriel SB, Samani NJ, Thompson JR, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Hall A, Wellcome Trust Case Control Consortium, Schunkert H, Erdmann J, Linsel-Nitschke P, Lieb W, Ziegler A, König I, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Schunkert H, Samani NJ, Erdmann J, Ouwehand W, Hengstenberg C, Deloukas P, Scholz M, Cambien F, Reilly MP, Li M, Chen Z, Wilensky R, Matthai W, Qasim A, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser V, Epstein SE, Rader DJ, Scheffold T, Berger K, Stoll M, Huge A, Girelli D, Martinelli N, Olivieri O, Corrocher R, Morgan T, Spertus JA, McKeown P, Patterson CC, Schunkert H, Erdmann E, Linsel-Nitschke P, Lieb W, Ziegler A, König IR, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Hólm H, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Engert JC, Do R, Xie C, Anand S, Kathiresan S, Ardissino D, Mannucci PM, Siscovick D, O'Donnell CJ, Samani NJ, Melander O, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Altshuler D., Free PMC Article

    03/25/2009
    Expression and/or function of SMIT2 may be reduced in diabetes mellitus, insulin resistance and polycystic ovary syndrome causing abnormal inositol meteabolism

    Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells.
    Lin X, Ma L, Fitzgerald RL, Ostlund RE Jr., Free PMC Article

    01/21/2010
    Tumor cells silence SLC5A8 and convert pyruvate into lactate as complementary mechanisms to avoid pyruvate-induced cell death.

    SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases.
    Thangaraju M, Gopal E, Martin PM, Ananth S, Smith SB, Prasad PD, Sterneck E, Ganapathy V.

    01/21/2010
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