| Regional bias of tumor suppressor gene mutations of STARD8 and WNK2 in colon cancers. | Regional bias of tumor suppressor gene mutations of STARD8 and WNK2 in colon cancers.
Mo HY, Moon SW, An CH, Lee SH. | 01/29/2024 |
| Germline mutations in WNK2 could be associated with serrated polyposis syndrome. | Germline mutations in WNK2 could be associated with serrated polyposis syndrome.
Soares de Lima Y, Arnau-Collell C, Muñoz J, Herrera-Pariente C, Moreira L, Ocaña T, Díaz-Gay M, Franch-Expósito S, Cuatrecasas M, Carballal S, Lopez-Novo A, Moreno L, Fernàndez G, Díaz de Bustamante A, Peters S, Sommer AK, Spier I, Te Paske IBAW, van Herwaarden YJ, Castells A, Bujanda L, Capellà G, Steinke-Lange V, Mahmood K, Joo JE, Arnold J, Parry S, Macrae FA, Winship IM, Rosty C, Cubiella J, Rodríguez-Alcalde D, Holinski-Feder E, de Voer R, Buchanan DD, Aretz S, Ruiz-Ponte C, Valle L, Balaguer F, Bonjoch L, Castellvi-Bel S., Free PMC Article | 05/24/2023 |
| WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia. | WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.
Rehman T, Karp PH, Thurman AL, Mather SE, Jain A, Cooney AL, Sinn PL, Pezzulo AA, Duffey ME, Welsh MJ., Free PMC Article | 10/8/2022 |
| Circ_0001666 affects miR-620/WNK2 axis to inhibit breast cancer progression. | Circ_0001666 affects miR-620/WNK2 axis to inhibit breast cancer progression.
Su N, Liu L, He S, Zeng L. | 02/26/2022 |
| LINC00858 knockdown inhibits gastric cancer cell growth and induces apoptosis through reducing WNK2 promoter methylation. | LINC00858 knockdown inhibits gastric cancer cell growth and induces apoptosis through reducing WNK2 promoter methylation.
Du J, Liang Y, Li J, Zhao JM, Lin XY. | 06/5/2021 |
| Genomic sequencing identifies WNK2 as a driver in hepatocellular carcinoma and a risk factor for early recurrence. | Genomic sequencing identifies WNK2 as a driver in hepatocellular carcinoma and a risk factor for early recurrence.
Zhou SL, Zhou ZJ, Hu ZQ, Song CL, Luo YJ, Luo CB, Xin HY, Yang XR, Shi YH, Wang Z, Huang XW, Cao Y, Fan J, Zhou J. | 03/20/2021 |
| Long non-coding RNA LINC00858 inhibits colon cancer cell apoptosis, autophagy, and senescence by activating WNK2 promoter methylation. | Long non-coding RNA LINC00858 inhibits colon cancer cell apoptosis, autophagy, and senescence by activating WNK2 promoter methylation.
Wu J, Meng X, Gao R, Jia Y, Chai J, Zhou Y, Wang J, Xue X, Dang T. | 03/13/2021 |
| WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line. | WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line.
Alves ALV, Costa AM, Martinho O, da Silva VD, Jordan P, Silva VAO, Reis RM., Free PMC Article | 02/20/2021 |
| Long non-coding RNA LINC00858 exerts a tumor-promoting role in colon cancer via HNF4alpha and WNK2 regulation. | Long non-coding RNA LINC00858 exerts a tumor-promoting role in colon cancer via HNF4α and WNK2 regulation.
Xu T, Wu K, Zhang L, Zheng S, Wang X, Zuo H, Wu X, Tao G, Jiang B, Zhang L. | 12/12/2020 |
| The data suggest that miR-370 acts as an oncogene by downregulating WNK2 in breast cancer. | microRNA-370 Promotes Cell Growth by Targeting WNK2 in Breast Cancer.
Huang L, Liu X. | 06/15/2019 |
| WNK2 promoter methylation and silencing in gliomas is associated with increased JNK activation and MMP2 expression and activity, thus explaining in part tumor cell invasion potential. | Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas.
Costa AM, Pinto F, Martinho O, Oliveira MJ, Jordan P, Reis RM., Free PMC Article | 12/5/2015 |
| Downregulation of WNK2 by promoter hypermethylation occurs early in Pancreatic ductal adenocarcinoma pathogenesis and may support tumor cell growth via the ERK-MAPK pathway. | Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development.
Dutruel C, Bergmann F, Rooman I, Zucknick M, Weichenhan D, Geiselhart L, Kaffenberger T, Rachakonda PS, Bauer A, Giese N, Hong C, Xie H, Costello JF, Hoheisel J, Kumar R, Rehli M, Schirmacher P, Werner J, Plass C, Popanda O, Schmezer P. | 08/30/2014 |
| Wnk kinases are positive regulators of canonical Wnt/beta-catenin signaling. | Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling.
Serysheva E, Berhane H, Grumolato L, Demir K, Balmer S, Bodak M, Boutros M, Aaronson S, Mlodzik M, Jenny A., Free PMC Article | 10/26/2013 |
| results validate the WNK2 gene as a recurrent target for epigenetic silencing in glia-derived brain tumours and provide first mechanistic evidence for a tumour-suppressing role of WNK2 that is related to Rac1 signalling and tumour cell invasion and growth | Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness.
Moniz S, Martinho O, Pinto F, Sousa B, Loureiro C, Oliveira MJ, Moita LF, Honavar M, Pinheiro C, Pires M, Lopes JM, Jones C, Costello JF, Paredes J, Reis RM, Jordan P. | 05/18/2013 |
| a role for WNK2 in the regulation of CCCs in the mammalian brain, with implications for both cell volume regulation and/or GABAergic signaling. | WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.
Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP., Free PMC Article | 10/22/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Association of gene polymorphisms with chronic kidney disease in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. | 12/2/2009 |
| Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific. | Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.
Jun P, Hong C, Lal A, Wong JM, McDermott MW, Bollen AW, Plass C, Held WA, Smiraglia DJ, Costello JF., Free PMC Article | 01/21/2010 |
| WNK2 controls a RhoA-mediated cross-talk mechanism that regulates the efficiency with which MEK1 can activate ERK1/2 upon growth factor stimulation. | WNK2 modulates MEK1 activity through the Rho GTPase pathway.
Moniz S, Matos P, Jordan P. | 01/21/2010 |
| epigenetic silencing, occasional deletion and point mutation, and functional assessment suggest that aberrations of WNK2 may contribute to unregulated tumor cell growth | Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth.
Hong C, Moorefield KS, Jun P, Aldape KD, Kharbanda S, Phillips HS, Costello JF., Free PMC Article | 01/21/2010 |
| WNK2 is involved in the modulation of growth factor-induced cancer cell proliferation through the MEK1/ERK1/2 pathway. | Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.
Moniz S, Veríssimo F, Matos P, Brazão R, Silva E, Kotelevets L, Chastre E, Gespach C, Jordan P. | 01/21/2010 |