| The effect of sodium iodide symporter protein on ablation success in patients with differentiated thyroid cancer. | The effect of sodium iodide symporter protein on ablation success in patients with differentiated thyroid cancer.
Mutevelızade G, Kocer NE, Reyhan M. | 11/26/2022 |
| Silent but Not Harmless: A Synonymous SLC5A5 Gene Variant Leading to Dyshormonogenic Congenital Hypothyroidism. | Silent but Not Harmless: A Synonymous SLC5A5 Gene Variant Leading to Dyshormonogenic Congenital Hypothyroidism.
Geysels RC, Bernal Barquero CE, Martín M, Peyret V, Nocent M, Sobrero G, Muñoz L, Signorino M, Testa G, Castro RB, Masini-Repiso AM, Miras MB, Nicola JP., Free PMC Article | 07/30/2022 |
| Seaweed and Iodine Intakes and SLC5A5 rs77277498 in Relation to Thyroid Cancer. | Seaweed and Iodine Intakes and SLC5A5 rs77277498 in Relation to Thyroid Cancer.
Hoang T, Lee EK, Lee J, Hwangbo Y, Kim J., Free PMC Article | 07/16/2022 |
| Impact of the Mutational Landscape of the Sodium/Iodide Symporter in Congenital Hypothyroidism. | Impact of the Mutational Landscape of the Sodium/Iodide Symporter in Congenital Hypothyroidism.
Martín M, Nicola JP. | 05/14/2022 |
| Brief Report: A Novel Sodium/Iodide Symporter Mutation, S356F, Causing Congenital Hypothyroidism. | Brief Report: A Novel Sodium/Iodide Symporter Mutation, S356F, Causing Congenital Hypothyroidism.
Durgia H, Nicholas AK, Schoenmakers E, Dickens JA, Halanaik D, Sahoo J, Kamalanathan S, Schoenmakers N., Free PMC Article | 05/14/2022 |
| The complex regulation of NIS expression and activity in thyroid and extrathyroidal tissues. | The complex regulation of NIS expression and activity in thyroid and extrathyroidal tissues.
Riesco-Eizaguirre G, Santisteban P, De la Vieja A. | 04/30/2022 |
| An Intramolecular Ionic Interaction Linking Defective Sodium/Iodide Symporter Transport to the Plasma Membrane and Dyshormonogenic Congenital Hypothyroidism. | An Intramolecular Ionic Interaction Linking Defective Sodium/Iodide Symporter Transport to the Plasma Membrane and Dyshormonogenic Congenital Hypothyroidism.
Bernal Barquero CE, Martín M, Geysels RC, Peyret V, Papendieck P, Masini-Repiso AM, Chiesa AE, Nicola JP. | 03/26/2022 |
| The Iodide Transport Defect-Causing Y348D Mutation in the Na(+)/I(-) Symporter Renders the Protein Intrinsically Inactive and Impairs Its Targeting to the Plasma Membrane. | The Iodide Transport Defect-Causing Y348D Mutation in the Na(+)/I(-) Symporter Renders the Protein Intrinsically Inactive and Impairs Its Targeting to the Plasma Membrane.
Reyna-Neyra A, Jung L, Chakrabarti M, Suárez MX, Amzel LM, Carrasco N., Free PMC Article | 03/19/2022 |
| Downregulation of Rap1GAP Expression Activates the TGF-beta/Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells. | Downregulation of Rap1GAP Expression Activates the TGF-β/Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells.
Yan Z, Yangyanqiu W, Shuwen H, Jing M, Haihong L, Gong C, Yin J, Qing Z, Weili G., Free PMC Article | 01/22/2022 |
| Clinical characteristics, surgical approach, BRAFV600E mutation and sodium iodine symporter expression in pediatric patients with thyroid carcinoma. | Clinical characteristics, surgical approach, BRAFV600E mutation and sodium iodine symporter expression in pediatric patients with thyroid carcinoma.
Castro P, Patiño E, Fierro F, Rojas C, Buitrago G, Olaya N. | 08/28/2021 |
| The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane. | The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane.
Martín M, Salleron L, Peyret V, Geysels RC, Darrouzet E, Lindenthal S, Bernal Barquero CE, Masini-Repiso AM, Pourcher T, Nicola JP. | 07/24/2021 |
| Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma. | Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma.
Rakhsh-Khorshid H, Samimi H, Torabi S, Sajjadi-Jazi SM, Samadi H, Ghafouri F, Asgari Y, Haghpanah V., Free PMC Article | 03/28/2021 |
| Allosteric regulation of mammalian Na(+)/I(-) symporter activity by perchlorate. | Allosteric regulation of mammalian Na(+)/I(-) symporter activity by perchlorate.
Llorente-Esteban A, Manville RW, Reyna-Neyra A, Abbott GW, Amzel LM, Carrasco N., Free PMC Article | 10/31/2020 |
| Dimerization of the Sodium/Iodide Symporter. | Dimerization of the Sodium/Iodide Symporter.
Thompson RJ, Fletcher A, Brookes K, Nieto H, Alshahrani MM, Mueller JW, Fine NHF, Hodson DJ, Boelaert K, Read ML, Smith VE, McCabe CJ., Free PMC Article | 10/24/2020 |
| Iodine131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma. | Iodine‑131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma.
Brito AF, Abrantes AM, Teixo R, Pires AS, Ribeiro AC, Ferreira RF, Mascarenhas A, Puga T, Laranjo M, Caramelo F, Boin I, Jefferson DM, Gonçalves C, Martins R, Tavares I, Ribeiro IP, Sarmento-Ribeiro AB, Carreira IM, Souza D, Tralhão JG, Botelho MF., Free PMC Article | 10/10/2020 |
| Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell-Mediated Sodium Iodide Symporter (NIS) Gene (131)I Therapy. | Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell-Mediated Sodium Iodide Symporter (NIS) Gene (131)I Therapy.
Schug C, Kitzberger C, Sievert W, Spellerberg R, Tutter M, Schmohl KA, Eberlein B, Biedermann T, Steiger K, Zach C, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, Spitzweg C. | 09/26/2020 |
| this study shows the important role of mannosidase in N-glycosylation processing in order to correctly traffic NIS to the plasma membrane in breast cancer cells. | Mannose glycosylation is an integral step for NIS localization and function in human breast cancer cells.
Rathod M, Chatterjee S, Dutta S, Kalraiya R, Bhattacharyya D, De A. | 07/18/2020 |
| Study identified two novel sodium iodide symporter (NIS) interactors, valosin-containing protein (VCP) and ADP-ribosylation factor 4 (ARF4), with critical roles in modulating NIS function as well as correlating markedly with clinical outcome in papillary thyroid cancer. ARF4 enhanced NIS vesicular trafficking from the Golgi to the plasma membrane, whereas VCP governed NIS proteolysis. | Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake.
Fletcher A, Read ML, Thornton CEM, Larner DP, Poole VL, Brookes K, Nieto HR, Alshahrani M, Thompson RJ, Lavery GG, Landa I, Fagin JA, Campbell MJ, Boelaert K, Turnell AS, Smith VE, McCabe CJ., Free PMC Article | 06/20/2020 |
| The data suggest that via inhibition of BCL-2 expression, overexpressed NES1 might enhance the effect of radiation therapy of (131)I uptake in hNIS overexpressed PC3 cells. | NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition.
Hu J, Shen W, Qu Q, Fei X, Miao Y, Huang X, Liu J, Wu Y, Li B. | 05/23/2020 |
| The intracellularly facing carboxy-terminus of NIS is required for the transport of the protein to the plasma membrane. | A Carboxy-Terminal Monoleucine-Based Motif Participates in the Basolateral Targeting of the Na+/I- Symporter.
Martín M, Modenutti CP, Peyret V, Geysels RC, Darrouzet E, Pourcher T, Masini-Repiso AM, Martí MA, Carrasco N, Nicola JP., Free PMC Article | 02/1/2020 |
| Acting as a critical regulator of autophagy-mediated NIS degradation via ROS/AMPK/mTOR pathway, HMGB1is a potential intervention target of radioiodine therapy in thyroid cancer. | HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells.
Chai W, Ye F, Zeng L, Li Y, Yang L., Free PMC Article | 01/18/2020 |
| NIS has a role in thyroid cancer cells that involves PTEN signaling | A Nonpump Function of Sodium Iodide Symporter in Thyroid Cancer via Cross-talk with PTEN Signaling.
Feng F, Yehia L, Ni Y, Chang YS, Jhiang SM, Eng C., Free PMC Article | 10/12/2019 |
| High sodium-iodide symporter expression is associated with gastric cancer. | Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.
Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E. | 09/7/2019 |
| Low NIS glycosylation is associated with Papillary Thyroid Carcinoma. | Post-translational Regulation of Radioactive Iodine Therapy Response in Papillary Thyroid Carcinoma.
Amit M, Na'ara S, Francis D, Matanis W, Zolotov S, Eisenhaber B, Eisenhaber F, Weiler Sagie M, Malkin L, Billan S, Charas T, Gil Z. | 02/16/2019 |
| Pendrin residues which are mutated in Pendred's syndrome are identical to those in the aligned position of sodium/iodide symporter (NIS) and apical iodide transporter (AIT). | Homology of pendrin, sodium-iodide symporter and apical iodide transporter.
Benvenga S, Guarneri F. | 01/26/2019 |