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    SLC6A2 solute carrier family 6 member 2 [ Homo sapiens (human) ]

    Gene ID: 6530, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Substrate binding and inhibition mechanism of norepinephrine transporter.

    Substrate binding and inhibition mechanism of norepinephrine transporter.
    Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX.

    10/5/2024
    Transport and inhibition mechanisms of the human noradrenaline transporter.

    Transport and inhibition mechanisms of the human noradrenaline transporter.
    Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y.

    09/17/2024
    Molecular basis of human noradrenaline transporter reuptake and inhibition.

    Molecular basis of human noradrenaline transporter reuptake and inhibition.
    Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C.

    09/10/2024
    Dimerization and antidepressant recognition at noradrenaline transporter.

    Dimerization and antidepressant recognition at noradrenaline transporter.
    Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y.

    06/17/2024
    Relationship between SLC6A2 gene polymorphisms and brain volume in Han Chinese adults who lost their sole child.

    Relationship between SLC6A2 gene polymorphisms and brain volume in Han Chinese adults who lost their sole child.
    Xia Z, Cao Z, Surento W, Zhang L, Qiu L, Xu Q, Zhang L, Li L, Cao Y, Luo Y, Lu G, Qi R., Free PMC Article

    01/17/2024
    Genotype-by-diagnosis interaction influences self-control in human cocaine addiction.

    Genotype-by-diagnosis interaction influences self-control in human cocaine addiction.
    Graczyk MM, Sahakian BJ, Robbins TW, Ersche KD., Free PMC Article

    02/15/2023
    The norepinephrine transporter gene modulates intrinsic brain activity, visual memory, and visual attention in children with attention-deficit/hyperactivity disorder.

    The norepinephrine transporter gene modulates intrinsic brain activity, visual memory, and visual attention in children with attention-deficit/hyperactivity disorder.
    Shang CY, Lin HY, Gau SS.

    01/29/2022
    Association between genetic variants of the norepinephrine transporter gene (SLC6A2) and bipolar I disorder.

    Association between genetic variants of the norepinephrine transporter gene (SLC6A2) and bipolar I disorder.
    Kim SY, Kim HN, Jeon SW, Lim WJ, Kim SI, Lee YJ, Kim SY, Kim YK.

    01/15/2022
    Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study.

    Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study.
    Malan L, Hamer M, von Känel R, Kotliar K, van Wyk RD, Lambert GW, Vilser W, Ziemssen T, Schlaich MP, Smith W, Magnusson M, Wentzel A, Myburgh CE, Steyn HS, Malan NT., Free PMC Article

    12/4/2021
    Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors.

    Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors.
    Sijben HJ, van Oostveen WM, Hartog PBR, Stucchi L, Rossignoli A, Maresca G, Scarabottolo L, IJzerman AP, Heitman LH., Free PMC Article

    10/23/2021
    Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population.

    Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population.
    Fichna JP, Humińska-Lisowska K, Safranow K, Adamczyk JG, Cięszczyk P, Żekanowski C, Berdyński M., Free PMC Article

    09/25/2021
    The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia.

    The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia.
    Rodrigues-Amorim D, Iglesias-Martínez-Almeida M, Rivera-Baltanás T, Fernández-Palleiro P, Freiría-Martínez L, Rodríguez-Jamardo C, Comís-Tuche M, Vallejo-Curto MDC, Álvarez-Ariza M, López-García M, de Las Heras E, García-Caballero A, Olivares JM, Spuch C., Free PMC Article

    09/18/2021
    The T-182C Polymorphism Enhances Promoter Activity of the Norepinephrine Transporter Gene, but may not be Associated with Antidepressant Response.

    The T-182C Polymorphism Enhances Promoter Activity of the Norepinephrine Transporter Gene, but may not be Associated with Antidepressant Response.
    Zhao X, Cui W, Liu Q, Cao S, Pang J, Li H.

    07/17/2021
    Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity-impulsivity symptoms in ADHD measured with PET.

    Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity-impulsivity symptoms in ADHD measured with PET.
    Sigurdardottir HL, Kranz GS, Rami-Mark C, James GM, Vanicek T, Gryglewski G, Berroterán-Infante N, Kautzky A, Hienert M, Traub-Weidinger T, Mitterhauser M, Wadsak W, Hartmann AM, Hacker M, Rujescu D, Kasper S, Lanzenberger R., Free PMC Article

    06/12/2021
    Norepinephrine transporter expressed on mammary epithelial cells incorporates norepinephrine in milk into the cells.

    Norepinephrine transporter expressed on mammary epithelial cells incorporates norepinephrine in milk into the cells.
    Chiba T, Takaguri A, Maeda T.

    05/15/2021
    Age-dependent association of polymorphisms in the promoter and 5'-untranslated region of the norepinephrine transporter gene with generalized anxiety disorder.

    Age-dependent association of polymorphisms in the promoter and 5'-untranslated region of the norepinephrine transporter gene with generalized anxiety disorder.
    Chang HA, Fang WH, Tzeng NS, Liu YP, Shyu JF, Wan FJ, Huang SY, Chang TC, Chang CC.

    04/17/2021
    The association between polymorphism of norepinephrine transporter G1287A and major depressive disorder, antidepressant response: a meta-analysis.

    The association between polymorphism of norepinephrine transporter G1287A and major depressive disorder, antidepressant response: a meta-analysis.
    Zhao X, Song C, Wang N, He J, Yang X, Zhang H, Deng Y, He Y, Liu Y, Li H, Cao S.

    12/19/2020
    Adult attention-deficit/hyperactivity disorder is associated with reduced norepinephrine transporter availability in right attention networks: a (S,S)-O-[(11)C]methylreboxetine positron emission tomography study.

    Adult attention-deficit/hyperactivity disorder is associated with reduced norepinephrine transporter availability in right attention networks: a (S,S)-O-[(11)C]methylreboxetine positron emission tomography study.
    Ulke C, Rullmann M, Huang J, Luthardt J, Becker GA, Patt M, Meyer PM, Tiepolt S, Hesse S, Sabri O, Strauß M., Free PMC Article

    09/26/2020
    this case control study showed that NET gene polymorphism (G1287A, rs5569) was significantly associated with type 2 diabetes mellitus (T2DM) in North Indian male population where AG genotype and A allele was found to be protective against the risk of T2DM while the GG genotype and G allele were found to increase the risk of T2DM.

    Association of endothelial nitric oxide synthase (eNOS) and norepinephrine transporter (NET) genes polymorphism with type 2 diabetes mellitus.
    Rizvi S, Raza ST, Rahman Q, Eba A, Zaidi ZH, Mahdi F.

    03/14/2020
    In this specific chronic heart failure population polymorphism of SLC6A2 gene was not associated with any (123)I-mIBG derived parameters.

    Polymorphism of SLC6A2 gene does not influence outcome of myocardial (123)I-mIBG scintigraphy in patients with chronic heart failure.
    Verschure DO, Baas F, van Eck-Smit BLF, Somsen GA, Verberne HJ., Free PMC Article

    10/26/2019
    NET gene rs5569 polymorphism could increase the risk of major depressive disorder, especially among Asians(Meta-Analysis)

    Meta-analysis on the Association Between Norepinephrine Transporter Gene rs2242446, rs5569 Polymorphisms and Risk of Major Depressive Disorder.
    Rui H, Qian H, Shi M, Zhang G, Wang L.

    10/26/2019
    Using RNA of isolated chromatin combined with massive parallel sequencing (RICh-seq) we show that let-7i miRNA suppresses NET by methyl-CpG-binding protein 2 (MeCP2)

    NET silencing by let-7i in postural tachycardia syndrome.
    Khan AW, Ziemann M, Corcoran SJ, K N H, Okabe J, Rafehi H, Maxwell SS, Esler MD, El-Osta A., Free PMC Article

    08/24/2019
    A SNP in the NET gene in patients with resistant hypertension is associated with higher plasma noradrenaline concentration and elevated SBP. Impaired NET function may be a contributor to the pronounced activation of the sympathetic nervous system characteristic of patients with resistant hypertension.

    A polymorphism in the noradrenaline transporter gene is associated with increased blood pressure in patients with resistant hypertension.
    Eikelis N, Marques FZ, Hering D, Marusic P, Head GA, Walton AS, Lambert EA, Esler MD, Sari CI, Schlaich MP, Lambert GW.

    06/29/2019
    Study shows a functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety.

    A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety.
    Hommers LG, Richter J, Yang Y, Raab A, Baumann C, Lang K, Schiele MA, Weber H, Wittmann A, Wolf C, Alpers GW, Arolt V, Domschke K, Fehm L, Fydrich T, Gerlach A, Gloster AT, Hamm AO, Helbig-Lang S, Kircher T, Lang T, Pané-Farré CA, Pauli P, Pfleiderer B, Reif A, Romanos M, Straube B, Ströhle A, Wittchen HU, Frantz S, Ertl G, Lohse MJ, Lueken U, Deckert J., Free PMC Article

    04/6/2019
    Pharmacogenetic association analyses of the norepinephrine transporter (NET, SLC6A2) gene in methylphenidate response among Hungarian Attention Deficit Hyperactivity Disorder (ADHD) children pointed to the possible involvement of the promoter - 3081 A/T SNP (rs28386840), which was supported by a meta-analysis combining our results using Central-European ADHD population with published data of Korean ADHD samples.

    Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients.
    Angyal N, Horvath EZ, Tarnok Z, Richman MJ, Bognar E, Lakatos K, Sasvari-Szekely M, Nemoda Z.

    02/16/2019
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