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    BMP6 bone morphogenetic protein 6 [ Homo sapiens (human) ]

    Gene ID: 654, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    BMP6 and VDR gene polymorphisms are associated with osteonecrosis in a sickle cell anaemia cohort.

    BMP6 and VDR gene polymorphisms are associated with osteonecrosis in a sickle cell anaemia cohort.
    Arcanjo GS, Souza MB, Domingos IF, Pereira-Martins DA, Falcão DA, Batista JV, Hatzlhofer BL, Diniz MV, Silva AP, Guaraná WL, Hazin MF, Araujo AS, Cunha AF, Saad SO, Costa FF, Lucena-Araujo AR, Bezerra MAC.

    04/17/2024
    Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome.

    Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome.
    Xin X, Chang HM, Leung PCK, Dong L, Li J, Lian F, Wu H., Free PMC Article

    01/26/2024
    BMP6 participates in the pathogenesis of adolescent idiopathic scoliosis by regulating osteopenia.

    BMP6 participates in the pathogenesis of adolescent idiopathic scoliosis by regulating osteopenia.
    Tang H, Li J, Li JK, He SH, Xiang G, Rong R, Liang ZT, Zhang HQ.

    11/22/2023
    RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.

    RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.
    Novak R, Ahmad YA, Timaner M, Bitman-Lotan E, Oknin-Vaisman A, Horwitz R, Hartmann O, Reissland M, Buck V, Rosenfeldt M, Nikomarov D, Diefenbacher ME, Shaked Y, Orian A., Free PMC Article

    10/15/2022
    Blood BMP6 Associated with Cognitive Performance and Alzheimer's Disease Diagnosis: A Longitudinal Study of Elders.

    Blood BMP6 Associated with Cognitive Performance and Alzheimer's Disease Diagnosis: A Longitudinal Study of Elders.
    Sun L, Guo C, Song Y, Sheng J, Xiao S, Alzheimer’s Disease Neuroimaging Initiative.

    07/30/2022
    Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.

    Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.
    Niikura T, Oda T, Jimbo N, Komatsu M, Oe K, Fukui T, Matsumoto T, Hayashi S, Matsushita T, Itoh T, Kuroda R., Free PMC Article

    04/2/2022
    The effect of cellular and physiological indicators on gender determination.

    The effect of cellular and physiological indicators on gender determination.
    Haje MI.

    04/2/2022
    Bone morphogenetic protein 6-mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron-sensing pathway in vitro.

    Bone morphogenetic protein 6-mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron-sensing pathway in vitro.
    Wang S, Chen C, Yu L, Mueller J, Rausch V, Mueller S., Free PMC Article

    02/19/2022
    Bone morphogenetic protein 6 expression in cumulus cells is negatively associated with oocyte maturation.

    Bone morphogenetic protein 6 expression in cumulus cells is negatively associated with oocyte maturation.
    Liu Y, Chen M, Zhao X, Ren X, Shao S, Zou M, Zhang L.

    01/29/2022
    BMP6 increases CD68 expression by up-regulating CTGF expression in human granulosa-lutein cells.

    BMP6 increases CD68 expression by up-regulating CTGF expression in human granulosa-lutein cells.
    Zhang XY, Chang HM, Yi Y, Zhu H, Liu RZ, Leung PCK.

    01/22/2022
    Runx3 regulates iron metabolism via modulation of BMP signalling.

    Runx3 regulates iron metabolism via modulation of BMP signalling.
    Kim HY, Lee JM, Lee YS, Li S, Lee SJ, Bae SC, Jung HS., Free PMC Article

    12/25/2021
    Novel BMP6 gene mutation in patient with iron overload.

    Novel BMP6 gene mutation in patient with iron overload.
    Tchernitchko D, Lamoril J.

    08/14/2021
    Genome-wide Association Analysis Across 16,956 Patients Identifies a Novel Genetic Association Between BMP6, NIPAL1, CNGA1 and Spondylosis.

    Genome-wide Association Analysis Across 16,956 Patients Identifies a Novel Genetic Association Between BMP6, NIPAL1, CNGA1 and Spondylosis.
    Zhang Y, Grant RA, Shivakumar MK, Zaleski M, Sofoluke N, Slotkin JR, Williams MS, Lee MTM.

    07/3/2021
    BMP-6 and SMAD4 gene expression is altered in cumulus cells from women with endometriosis-associated infertility.

    BMP-6 and SMAD4 gene expression is altered in cumulus cells from women with endometriosis-associated infertility.
    De Conto E, Matte U, Cunha-Filho JS.

    06/19/2021
    Synergistic interaction of hTGF-beta3 with hBMP-6 promotes articular cartilage formation in chitosan scaffolds with hADSCs: implications for regenerative medicine.

    Synergistic interaction of hTGF-β(3) with hBMP-6 promotes articular cartilage formation in chitosan scaffolds with hADSCs: implications for regenerative medicine.
    Huang Y, Seitz D, Chevalier Y, Müller PE, Jansson V, Klar RM., Free PMC Article

    06/19/2021
    BMP6 binding to heparin and heparan sulfate is mediated by N-terminal and C-terminal clustered basic residues.

    BMP6 binding to heparin and heparan sulfate is mediated by N-terminal and C-terminal clustered basic residues.
    Denardo A, Elli S, Federici S, Asperti M, Gryzik M, Ruzzenenti P, Carmona F, Bergese P, Naggi A, Arosio P, Poli M.

    04/24/2021
    Identification of Pathogenic Genes and Transcription Factors in Osteosarcoma.

    Identification of Pathogenic Genes and Transcription Factors in Osteosarcoma.
    Yang C, Huang D, Ma C, Ren J, Fu L, Cheng C, Li B, Shi X.

    04/3/2021
    miR-765 inhibits the osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting BMP6 via regulating the BMP6/Smad1/5/9 signaling pathway.

    miR-765 inhibits the osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting BMP6 via regulating the BMP6/Smad1/5/9 signaling pathway.
    Wang T, Zhang C, Wu C, Liu J, Yu H, Zhou X, Zhang J, Wang X, He S, Xu X, Ma B, Che X, Li W., Free PMC Article

    03/20/2021
    Novel mutations in the bone morphogenetic protein 6 gene in patients with iron overload and non-homozygous genotype for the HFE p.Cys282Tyr mutation.

    Novel mutations in the bone morphogenetic protein 6 gene in patients with iron overload and non-homozygous genotype for the HFE p.Cys282Tyr mutation.
    Alvarenga AM, da Silva NK, Fonseca PFS, Oliveira TGM, da Silva Monteiro JB, Cançado RD, Naoum FA, Dinardo CL, Brissot P, Santos PCJL.

    01/16/2021
    BMP6 Regulates Corneal Epithelial Cell Stratification by Coordinating Their Proliferation and Differentiation and Is Upregulated in Pterygium.

    BMP6 Regulates Corneal Epithelial Cell Stratification by Coordinating Their Proliferation and Differentiation and Is Upregulated in Pterygium.
    Tiwari A, Swamynathan S, Campbell G, Jhanji V, Swamynathan SK., Free PMC Article

    01/9/2021
    Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.

    Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.
    Lim PJ, Duarte TL, Arezes J, Garcia-Santos D, Hamdi A, Pasricha SR, Armitage AE, Mehta H, Wideman S, Santos AG, Santos-Gonçalves A, Morovat A, Hughes JR, Soilleux E, Wang CY, Bayer AL, Klenerman P, Willberg CB, Hartley RC, Murphy MP, Babitt JL, Ponka P, Porto G, Drakesmith H., Free PMC Article

    01/9/2021
    Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjogren's syndrome in mice.

    Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjögren's syndrome in mice.
    Yin H, Kalra L, Lai Z, Guimaro MC, Aber L, Warner BM, Michael D, Zhang N, Cabrera-Perez J, Karim A, Swaim WD, Afione S, Voigt A, Nguyen CQ, Yu PB, Bloch DB, Chiorini JA., Free PMC Article

    11/21/2020
    Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin.

    Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin.
    Kondkar AA, Sultan T, Azad TA, Osman EA, Almobarak FA, Al-Obeidan SA., Free PMC Article

    10/31/2020
    demonstrate that ALK2 and ALK3 BMP type I receptors are involved in BMP6-induced suppressive effects on Cx43 expression

    Bone morphogenetic protein 6 affects cell-cell communication by altering the expression of Connexin43 in human granulosa-lutein cells.
    Wu HC, Chang HM, Yi Y, Sun ZG, Lin YM, Lian F, Leung PCK.

    06/27/2020
    Study detected that BMP6 is significantly increased in skin-derived fibroblasts of patients with localized scleroderma. Moreover, it was shown that BMP6 significantly impacts proliferation, migration, cytoskeletal organization, and collagen expression, as well as activity of the major pro-fibrogenic transcription factor AP-1 in dermal fibroblasts.

    Bone Morphogenetic Protein-6 Inhibits Fibrogenesis in Scleroderma Offering Treatment Options for Fibrotic Skin Disease.
    Arndt S, Karrer S, Hellerbrand C, Bosserhoff AK.

    06/20/2020
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