| Oncogenic KRAS Induces Arginine Auxotrophy and Confers a Therapeutic Vulnerability to SLC7A1 Inhibition in Non-Small Cell Lung Cancer. | Oncogenic KRAS Induces Arginine Auxotrophy and Confers a Therapeutic Vulnerability to SLC7A1 Inhibition in Non-Small Cell Lung Cancer.
Gai X, Liu Y, Lan X, Chen L, Yuan T, Xu J, Li Y, Zheng Y, Yan Y, Yang L, Fu Y, Tang S, Cao S, Dai X, Zhu H, Geng M, Ding J, Pu C, Huang M. | 09/23/2024 |
| The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier. | The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier.
Kurtyka M, Wessely F, Bau S, Ifie E, He L, de Wit NM, Pedersen ABV, Keller M, Webber C, de Vries HE, Ansorge O, Betsholtz C, De Bock M, Chaves C, Brodin B, Nielsen MS, Neuhaus W, Bell RD, Letoha T, Meyer AH, Leparc G, Lenter M, Lesuisse D, Cader ZM, Buckley ST, Loryan I, Pietrzik CU. | 07/18/2024 |
| High expression of SLC7A1 in high-grade serous ovarian cancer promotes tumor progression and is involved in MAPK/ERK pathway and EMT. | High expression of SLC7A1 in high-grade serous ovarian cancer promotes tumor progression and is involved in MAPK/ERK pathway and EMT.
You S, Han X, Xu Y, Sui L, Song K, Yao Q., Free PMC Article | 07/15/2024 |
| High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies. | High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies.
Contreras-Duarte S, Cantin C, Farias M, Leiva A. | 01/1/2022 |
| Human cationic amino acid transporters are not affected by direct nitros(yl)ation. | Human cationic amino acid transporters are not affected by direct nitros(yl)ation.
Hobbach AJ, Closs EI. | 11/28/2020 |
| L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B. | The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.
Chafai A, Fromm MF, König J, Maas R., Free PMC Article | 01/12/2019 |
| Estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK. Progesterone inhibits arginine transport and CAT-1 via both PKCalpha and ERK1/2 phosphorylation. | Estradiol augments while progesterone inhibits arginine transport in human endothelial cells through modulation of cationic amino acid transporter-1.
Bentur OS, Schwartz D, Chernichovski T, Ingbir M, Weinstein T, Chernin G, Schwartz IF. | 11/14/2015 |
| The rs41318021 polymorphism in the SLC7A1 gene was not associated with essential hypertension in 50-year-old subjects. | Contribution of SLC7A1 genetic variant to hypertension, the TAMRISK study.
Määttä K, Kunnas T, Nikkari ST., Free PMC Article | 09/13/2014 |
| Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue. | Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue.
Lu Y, Wang W, Wang J, Yang C, Mao H, Fu X, Wu Y, Cai J, Han J, Xu Z, Zhuang Z, Liu Z, Hu H, Chen B., Free PMC Article | 06/21/2014 |
| CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution. | Differential topochemistry of three cationic amino acid transporter proteins, hCAT1, hCAT2 and hCAT3, in the adult human brain.
Jäger K, Wolf S, Dobrowolny H, Steiner J, Nave H, Maronde E, Bogerts B, Bernstein HG. | 07/6/2013 |
| mRNA levels for high-affinity CAT-1, expressed as a percentage of the wild-type value, are increased by an average 12% and 32% in mdx and transgenic mdx:utr mice respectively. | Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters.
Ramachandran J, Schneider JS, Crassous PA, Zheng R, Gonzalez JP, Xie LH, Beuve A, Fraidenraich D, Peluffo RD., Free PMC Article | 02/9/2013 |
| The data demonstrates that CAT1 significantly (but most likely not exclusively) contributes to the cellular uptake of asymmetric dimethylarginine. | Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1).
Strobel J, Mieth M, Endress B, Auge D, König J, Fromm MF, Maas R. | 01/26/2013 |
| In hypoxic human pulmonary microvascular endothelial cells, overexpression of CAT-1 resulted in significantly greater L-arginine transport and NO production | Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells.
Cui H, Chen B, Chicoine LG, Nelin LD., Free PMC Article | 09/29/2012 |
| In acute congestive heart failure acute renal impairment function and the modulation of metabolism and extracellular transport by the DDAH-1/CAT-1 system determine high ADMA and SDMA levels after therapy for acute congestive heart failure. | The biological effect of pharmacological treatment on dimethylaminohydrolases (DDAH-1) and cationic amino acid transporter-1 (CAT-1) expression in patients with acute congestive heart failure.
Speranza L, Franceschelli S, D'Orazio N, Gaeta R, Bucciarelli T, Felaco M, Grilli A, Riccioni G. | 03/17/2012 |
| Insulin increased hCATs-L-arginine transport, maximal transport capacity, and hCAT-1 expression. Sp1 nuclear protein abundance and binding to DNA, and SLC7A1 promoter activity was increased by insulin. | Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation.
González M, Gallardo V, Rodríguez N, Salomón C, Westermeier F, Guzmán-Gutiérrez E, Abarzúa F, Leiva A, Casanello P, Sobrevia L. | 11/19/2011 |
| Data show that the CAT-1 isoform plays a role in arginine uptake. | CAT-1-mediated arginine uptake and regulation of nitric oxide synthases for the survival of human breast cancer cell lines.
Abdelmagid SA, Rickard JA, McDonald WJ, Thomas LN, Too CK. | 08/6/2011 |
| PKC activation also resulted in ubiquitination of CAT-1 | Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1.
Vina-Vilaseca A, Bender-Sigel J, Sorkina T, Closs EI, Sorkin A., Free PMC Article | 05/14/2011 |
| Data provide novel insights into the mechanism by which ss52051869 influences SLC7A1 gene expression. | Mechanistic insights into the link between a polymorphism of the 3'UTR of the SLC7A1 gene and hypertension.
Yang Z, Kaye DM. | 01/21/2010 |
| distribution of human cationic amino acid transporters 1 (hCAT1) and 2 (hCAT2) in healthy skin and compared it to psoriatic skin lesions by means of immunohistochemistry | Characterization of cationic amino acid transporters (hCATs) 1 and 2 in human skin.
Jaeger K, Paulsen F, Wohlrab J. | 01/21/2010 |
| CAT1 is directly involved in erythropoiesis through supplying arginine to the blood cells. | Changes of differentiation and proliferation in k562 cells with various levels of knockdown of cationic amino acid transporter 1.
Maeda T, Shima Y, Sugiura S, Aizawa S, Tamai I. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.
Yang Z, Venardos K, Jones E, Morris BJ, Chin-Dusting J, Kaye DM. | 03/13/2008 |
| Ornithine uptake in retinal pigment epithelium is depdendent on induction of SLC7A1 mRNA and spermine. | Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.
Kaneko S, Okuda-Ashitaka E, Ando A, Nishimura K, Igarashi K, Maeda M, Furuta K, Suzuki M, Matsumura M, Ito S. | 01/21/2010 |
| Keratinocytes express cationic amino acid transporters 1 and 2. Cationic amino acid transporter mediated L-arginine essential for inducible nitric oxide synthase and arginase enzyme, which modulate proliferation and differentiation of epidermal cells. | The importance of cationic amino acid transporter expression in human skin.
Schnorr O, Suschek CV, Kolb-Bachofen V. | 01/21/2010 |
| The CAT-1 is thought to supply substrate to endothelial NOS by virtue of its co-localisation with this enzyme. | Rate of transport of l-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells.
Cui Z, Tuladhar R, Hart SL, Marber MS, Pearson JD, Baydoun AR. | 01/21/2010 |
| Glomerular arginine uptake is elevated through modulation of CAT-1 expression, thus, contributing to the pathogenesis of hyperfiltration. Increased nitric oxide formation may play a role in this process. | Augmented arginine uptake, through modulation of cationic amino acid transporter-1, increases GFR in diabetic rats.
Schwartz IF, Iaina A, Benedict Y, Wollman Y, Chernichovski T, Brasowski E, Misonzhnik F, Ben-Dor A, Blum M, Levo Y, Schwartz D. | 01/21/2010 |