| OCTN1 (SLC22A4) displays two different transport pathways for organic cations or zwitterions. | OCTN1 (SLC22A4) displays two different transport pathways for organic cations or zwitterions.
Pochini L, Barone F, Console L, Brunocilla C, Galluccio M, Scalise M, Indiveri C. | 02/2/2024 |
| Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke. | Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke.
Lu D, Cai H, Li Y, Chang W, Liu X, Dai Q, Yu W, Chen W, Qiao G, Xie H, Xiao X, Li Z., Free PMC Article | 01/26/2024 |
| The ergothioneine transporter (ETT): substrates and locations, an inventory. | The ergothioneine transporter (ETT): substrates and locations, an inventory.
Gründemann D, Hartmann L, Flögel S. | 06/11/2022 |
| DNA Methylation-Based Epigenetic Repression of SLC22A4 Promotes Resistance to Cytarabine in Acute Myeloid Leukemia. | DNA Methylation-Based Epigenetic Repression of SLC22A4 Promotes Resistance to Cytarabine in Acute Myeloid Leukemia.
Buelow DR, Anderson JT, Pounds SB, Shi L, Lamba JK, Hu S, Gibson AA, Goodwin EA, Sparreboom A, Baker SD., Free PMC Article | 10/30/2021 |
| LPS-induced inflammation delays the transportation of ASP(+) due to down-regulation of OCTN1/2 in alveolar epithelial cells. | LPS-induced inflammation delays the transportation of ASP(+) due to down-regulation of OCTN1/2 in alveolar epithelial cells.
Li D, Qi C, Zhou J, Wen Z, Zhu X, Xia H, Song J. | 08/21/2021 |
| Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations. | Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations.
Costa ACC, Yamamoto PA, Lauretti GR, de Lima Benzi JR, Zanelli CF, Barz V, Ciarimboli G, de Moraes NV. | 07/10/2021 |
| Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men. | Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men.
Meisel P, Pagels S, Grube M, Jedlitschky G, Völzke H, Kocher T., Free PMC Article | 02/2/2021 |
| Ergothioneine is a biologically important compound that has been shown to be transported by the organic cation transporter novel type 1 (OCTN1). The present study reaffirms the primacy of ergothioneine over these alternate substrates using natively expressed OCTN1 in HeLa cells. | Specificity of the ergothioneine transporter natively expressed in HeLa cells.
Tucker RAJ, Cheah IK, Halliwell B. | 03/28/2020 |
| SLC22A4 gene polymorphism rs272893 is/associated with increased risk of type 2 diabetes in Chinese Han patients. | Relationship Between SLC22A1 and SLC22A4 Gene Polymorphisms and Risk of Type 2 Diabetes in Chinese Han Population.
Long G, Zhang G, Zhang F, Ye D, Yang D, Yang Y. | 09/21/2019 |
| It promotes neural stem cell differentiation into neurons. | [Possible Treatment of Neuropsychiatric Disorders by Promotion of Neuronal Differentiation through Organic Cation Transporters].
Nakamichi N, Masuo Y, Kato Y. | 07/13/2019 |
| The expression of SLC22A4, IL1R2 and VNN3, were independently associated with elevated neutrophil-to-lymphocyte ratio in chronic heart failure patients. | Screening genes associated with elevated neutrophil‑to‑lymphocyte ratio in chronic heart failure.
Wan G, Ji L, Xia W, Cheng L, Zhang Y., Free PMC Article | 11/3/2018 |
| Functional expression of Octn1 was demonstrated in activated hepatic stellate cell lines. | Localization of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis.
Tang Y, Masuo Y, Sakai Y, Wakayama T, Sugiura T, Harada R, Futatsugi A, Komura T, Nakamichi N, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kaneko S, Kato Y. | 12/9/2017 |
| Studies confirmed OCTN1-mediated transport of cytarabine and various structurally related cytidine analogues, such as 2'deoxycytidine and gemcitabine, occurs through a saturable process that is highly sensitive to inhibition by the classic nucleoside transporter inhibitors. | OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.
Drenberg CD, Gibson AA, Pounds SB, Shi L, Rhinehart DP, Li L, Hu S, Du G, Nies AT, Schwab M, Pabla N, Blum W, Gruber TA, Baker SD, Sparreboom A., Free PMC Article | 05/13/2017 |
| These data reveal a role of OCTN1 in transporting acetylcholine and choline in HeLa cells. | Immuno-detection of OCTN1 (SLC22A4) in HeLa cells and characterization of transport function.
Pochini L, Scalise M, Indiveri C. | 09/17/2016 |
| mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss. | A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60.
Ben Said M, Grati M, Ishimoto T, Zou B, Chakchouk I, Ma Q, Yao Q, Hammami B, Yan D, Mittal R, Nakamichi N, Ghorbel A, Neng L, Tekin M, Shi XR, Kato Y, Masmoudi S, Lu Z, Hmani M, Liu X., Free PMC Article | 09/3/2016 |
| Functional activity of L-carnitine transporters in human airway epithelial cells. | Functional activity of L-carnitine transporters in human airway epithelial cells.
Ingoglia F, Visigalli R, Rotoli BM, Barilli A, Riccardi B, Puccini P, Dall'Asta V. | 04/30/2016 |
| SLC22A4 was associated with joint erosion in not-very-longstanding RA, although RA susceptibility association was weak and its clinical significance was uncertain. | Association of joint erosion with SLC22A4 gene polymorphisms inconsistently associated with rheumatoid arthritis susceptibility.
Han TU, Lee HS, Kang C, Bae SC. | 04/9/2016 |
| Functional expression of OCTN1 was confirmed in LPS-stimulated human macrophage-like cell line, THP-1. | Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice.
Shimizu T, Masuo Y, Takahashi S, Nakamichi N, Kato Y. | 03/26/2016 |
| This meta-analysis demonstrates that the SLC22A4 F1 polymorphism is associated with susceptibility to RA in East Asians, but not in Europeans. | Meta-analysis of SLC22A4 and RUNX1 polymorphisms : Associations with rheumatoid arthritis susceptibility.
Lee YH, Bae SC, Kim JH, Seo YH, Choi SJ, Ji JD, Song GG. | 02/13/2016 |
| Report functional/molecular effects of mercury compounds on the human OCTN1 cation transporter: C50 and C136 are the targets for potent inhibition. | Functional and molecular effects of mercury compounds on the human OCTN1 cation transporter: C50 and C136 are the targets for potent inhibition.
Galluccio M, Pochini L, Peta V, Iannì M, Scalise M, Indiveri C. | 12/5/2015 |
| A lack of association between the SLC22A4 gene polymorphism rs3792876 and susceptibility to autoimmune thyroid diseases in a Chinese Han population. | Association of single nucleotide polymorphism rs3792876 in SLC22A4 gene with autoimmune thyroid disease in a Chinese Han population.
Hou X, Mao J, Li Y, Li J, Wang W, Fan C, Wang H, Zhang H, Shan Z, Teng W., Free PMC Article | 10/24/2015 |
| SLC22A4 gene polymorphisms played important roles in the etiology of rheumatoid arthritis in the Chinese population. | Association of SLC22A4 gene polymorphism with Rheumatoid arthritis in the Chinese population.
Ren TL, Han ZJ, Yang CJ, Hang YX, Fang DY, Wang K, Zhu X, Ji XJ, Zhou FF. | 12/20/2014 |
| Single nucleotide polymorphisms in SLC22A4 gene is associated with inborn errors of metabolism. | Metabolic heritability at birth: implications for chronic disease research.
Ryckman KK, Smith CJ, Jelliffe-Pawlowski LL, Momany AM, Berberich SL, Murray JC., Free PMC Article | 09/6/2014 |
| The selenoneine-mediated OCTN1 system regulates secretory lysosomal vesicle formation and MeHg demethylation. | Selenoneine, a novel selenium-containing compound, mediates detoxification mechanisms against methylmercury accumulation and toxicity in zebrafish embryo.
Yamashita M, Yamashita Y, Suzuki T, Kani Y, Mizusawa N, Imamura S, Takemoto K, Hara T, Hossain MA, Yabu T, Touhata K., Free PMC Article | 03/1/2014 |
| Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy | Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy.
Angelini S, Pantaleo MA, Ravegnini G, Zenesini C, Cavrini G, Nannini M, Fumagalli E, Palassini E, Saponara M, Di Battista M, Casali PG, Hrelia P, Cantelli-Forti G, Biasco G. | 06/22/2013 |