| A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus. | A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus.
Singh AK, Allington G, Viviano S, McGee S, Kiziltug E, Ma S, Zhao S, Mekbib KY, Shohfi JP, Duy PQ, DeSpenza T Jr, Furey CG, Reeves BC, Smith H, Sousa AMM, Cherskov A, Allocco A, Nelson-Williams C, Haider S, Rizvi SRA, Alper SL, Sestan N, Shimelis H, Walsh LK, Lifton RP, Moreno-De-Luca A, Jin SC, Kruszka P, Deniz E, Kahle KT., | 04/10/2024 |
| RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex. | RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.
Liu W, Wang Z, Liu S, Zhang X, Cao X, Jiang M. | 10/5/2023 |
| SMARCC1 is a susceptibility gene for congenital hydrocephalus with an autosomal dominant inheritance mode and incomplete penetrance. | SMARCC1 is a susceptibility gene for congenital hydrocephalus with an autosomal dominant inheritance mode and incomplete penetrance.
Hourvitz N, Kurolap A, Mory A, Haratz KK, Kidron D, Malinger G, Baris Feldman H, Yaron Y. | 09/14/2023 |
| First reports of fetal SMARCC1 related hydrocephalus. | First reports of fetal SMARCC1 related hydrocephalus.
Rive Le Gouard N, Nicolle R, Lefebvre M, Gelot A, Heide S, Gerasimenko A, Grigorescu R, Derive N, Jouannic JM, Garel C, Valence S, Quenum-Miraillet G, Chantot-Bastaraud S, Keren B, Heron D, Attie-Bitach T. | 08/3/2023 |
| Assembly and interaction of core subunits of BAF complexes and crystal study of the SMARCC1/SMARCE1 binary complex. | Assembly and interaction of core subunits of BAF complexes and crystal study of the SMARCC1/SMARCE1 binary complex.
Dong C, Zhang R, Xu L, Liu B, Chu X. | 03/19/2022 |
| Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. | Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler.
Woodley CM, Romer AS, Wang J, Guarnaccia AD, Elion DL, Maxwell JN, Guerrazzi K, McCann TS, Popay TM, Matlock BK, Flaherty DK, Lorey SL, Liu Q, Tansey WP, Weissmiller AM., Free PMC Article | 01/15/2022 |
| SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site. | SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.
Allen MD, Freund SMV, Bycroft M, Zinzalla G., Free PMC Article | 10/23/2021 |
| A Coil-to-Helix Transition Serves as a Binding Motif for hSNF5 and BAF155 Interaction. | A Coil-to-Helix Transition Serves as a Binding Motif for hSNF5 and BAF155 Interaction.
Han J, Kim I, Park JH, Yun JH, Joo K, Kim T, Park GY, Ryu KS, Ko YJ, Mizutani K, Park SY, Seong RH, Lee J, Suh JY, Lee W., Free PMC Article | 12/5/2020 |
| BAF155 plays important roles in ubiquitin-independent degradation of hepatitis B virus X protein | Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation.
Chen H, Zhang Y, Ye S, Wu Q, Lin Y, Sheng K, Chen W, Lin X, Lin X., Free PMC Article | 02/22/2020 |
| Study found SMARCC1 as a direct target of miR-202-5p and promoted the growth and metastasis of colorectal carcinoma (CRC) cells. Furthermore, SMARCC1 could reverse the inhibitory effect of miR-202-5p on growth and metastasis of CRC cells. | MicroRNA-202-5p functions as a tumor suppressor in colorectal carcinoma by directly targeting SMARCC1.
Ke SB, Qiu H, Chen JM, Shi W, Chen YS. | 09/15/2018 |
| our data showed that Swi3 strongly affects haem/oxygen-dependent activation of respiration gene promoters whereas Swi2 affects only the basal, haem-independent activities of these promoters. using computational analysis and RNAi knockdown, we showed that the mammalian Swi3 BAF155 and BAF170 regulate respiration in HeLa cells. | The Swi3 protein plays a unique role in regulating respiration in eukaryotes.
Lal S, Alam MM, Hooda J, Shah A, Cao TM, Xuan Z, Zhang L., Free PMC Article | 12/9/2017 |
| Here, the authors first confirmed that SWIRM domain of BAF155 is responsible for its interaction with BAF47 and then narrowed down the SWIRM-binding region in BAF47 to the Repeat 1 (RPT1) domain. | Structural Insights into BAF47 and BAF155 Complex Formation.
Yan L, Xie S, Du Y, Qian C. | 07/15/2017 |
| NKX6.1 directly enhances the mRNA level of E-cadherin by recruiting BAF155 coactivator and represses that of vimentin and N-cadherin by recruiting RBBP7 (retinoblastoma binding protein 7) corepressor. | NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial-mesenchymal transition.
Li HJ, Yu PN, Huang KY, Su HY, Hsiao TH, Chang CP, Yu MH, Lin YW., Free PMC Article | 06/24/2017 |
| Results show the secondary structure of SWIRM domain of BAF155 consists of five alpha-helices forming a typical histone fold for DNA interactions. | 1H, 15N, and 13C resonance assignments and secondary structure of the SWIRM domain of human BAF155, a chromatin remodeling complex component.
Moon S, Shin J, Lee D, Seong RH, Lee W., Free PMC Article | 06/7/2014 |
| we identify BAF155 as a substrate for arginine methyltransferase CARM1. | CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
Wang L, Zhao Z, Meyer MB, Saha S, Yu M, Guo A, Wisinski KB, Huang W, Cai W, Pike JW, Yuan M, Ahlquist P, Xu W., Free PMC Article | 03/29/2014 |
| Wwp2 acts as a ubiquitin ligase of SRG3. | Wwp2 targets SRG3, a scaffold protein of the SWI/SNF-like BAF complex, for ubiquitination and degradation.
Luo X, Wang B, Tang F, Zhang J, Zhao Y, Li H, Jin Y. | 03/22/2014 |
| miR-320c regulates the resistance of pancreatic cancer cells to gemcitabine through SMARCC1. | miR-320c regulates gemcitabine-resistance in pancreatic cancer via SMARCC1.
Iwagami Y, Eguchi H, Nagano H, Akita H, Hama N, Wada H, Kawamoto K, Kobayashi S, Tomokuni A, Tomimaru Y, Mori M, Doki Y., Free PMC Article | 10/19/2013 |
| loss of BAF155 expression represents another mechanism for inactivation of SWI/SNF complex activity in the development in human cancer. | Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene.
DelBove J, Rosson G, Strobeck M, Chen J, Archer TK, Wang W, Knudsen ES, Weissman BE., Free PMC Article | 04/7/2012 |
| Data show that the mechanism of BAF155-mediated stabilization of BAF57 involves blocking its ubiquitination by preventing interaction with TRIP12. | Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex.
Keppler BR, Archer TK., Free PMC Article | 02/26/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
So HC, Fong PY, Chen RY, Hui TC, Ng MY, Cherny SS, Mak WW, Cheung EF, Chan RC, Chen EY, Li T, Sham PC. | 12/2/2009 |
| patients with tumours displaying high levels of CBFB and SMARCC1 proteins had a significantly better overall survival rate than patients with low levels | Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.
Andersen CL, Christensen LL, Thorsen K, Schepeler T, Sørensen FB, Verspaget HW, Simon R, Kruhøffer M, Aaltonen LA, Laurberg S, Ørntoft TF., Free PMC Article | 01/21/2010 |
| An increased expression of SMARCC1 protein was found in prostate cancer positively correlated with tumour dedifferentiation, progression, metastasis and time to recurrence. | SMARCC1 expression is upregulated in prostate cancer and positively correlated with tumour recurrence and dedifferentiation.
Heebøll S, Borre M, Ottosen PD, Andersen CL, Mansilla F, Dyrskjøt L, Orntoft TF, Tørring N. | 01/21/2010 |
| Constitutive expression of SRG3 inhibits positive selection processes in T-cell receptor transgenic mice. | Down-regulation of the SWI/SNF chromatin remodeling activity by TCR signaling is required for proper thymocyte maturation.
Lee KY, Choi YI, Kim J, Choi JW, Sohn DH, Lee C, Jeon SH, Seong RH. | 01/21/2010 |
| protein levels of BAF155/170 dictate the maximum cellular amount of BAF57 | Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57.
Chen J, Archer TK., Free PMC Article | 01/21/2010 |