| Lynx1 and the family of endogenous mammalian neurotoxin-like proteins and their roles in modulating nAChR function. | Lynx1 and the family of endogenous mammalian neurotoxin-like proteins and their roles in modulating nAChR function.
Palumbo TB, Miwa JM. | 08/25/2023 |
| Spatial Structure and Activity of Synthetic Fragments of Lynx1 and of Nicotinic Receptor Loop C Models. | Spatial Structure and Activity of Synthetic Fragments of Lynx1 and of Nicotinic Receptor Loop C Models.
Mineev KS, Kryukova EV, Kasheverov IE, Egorova NS, Zhmak MN, Ivanov IA, Senko DA, Feofanov AV, Ignatova AA, Arseniev AS, Utkin YN, Tsetlin VI., Free PMC Article | 06/26/2021 |
| Increased Expression of LYNX1 in Ovarian Serous Cystadenocarcinoma Predicts Poor Prognosis. | Increased Expression of LYNX1 in Ovarian Serous Cystadenocarcinoma Predicts Poor Prognosis.
Liu H, Wang A, Ma Y., Free PMC Article | 06/12/2021 |
| The ability of ws-Lynx1 to regulate homeostasis of epithelial cancer cells. | Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors.
Bychkov M, Shenkarev Z, Shulepko M, Shlepova O, Kirpichnikov M, Lyukmanova E., Free PMC Article | 01/25/2020 |
| results show that some functional and behavioral aspects of alpha6-nAChRs are modulated by lynx1 | Deletion of lynx1 reduces the function of α6* nicotinic receptors.
Parker RL, O'Neill HC, Henley BM, Wageman CR, Drenan RM, Marks MJ, Miwa JM, Grady SR, Lester HA., Free PMC Article | 12/30/2017 |
| These findings provide new insights into the acetylcholine receptor-mediated regulatory mechanism of SLURP-2 expression in keratinocytes. | Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: A special reference to the nested gene LYNX1.
Moriwaki Y, Takada K, Tsuji S, Kawashima K, Misawa H. | 09/29/2017 |
| These studies suggest that lynx1 is a potential target both for development of drugs that may limit lung cancer growth as well as for drugs that may be effective for asthma or COPD treatment. | Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium.
Fu XW, Song PF, Spindel ER., Free PMC Article | 09/17/2016 |
| This epigenome-wide DNA methylation analysis in postmortem hippocampus and prefrontal cortex specimens confirmed LYNX1 DNA methylation profiles in major depression. | Aberrant NMDA receptor DNA methylation detected by epigenome-wide analysis of hippocampus and prefrontal cortex in major depression.
Kaut O, Schmitt I, Hofmann A, Hoffmann P, Schlaepfer TE, Wüllner U, Hurlemann R. | 01/30/2016 |
| Micromolar affinities and fast washout rates measured for ws-LYNX1 and its mutants are in contrast to nanomolar affinities and irreversibility of binding for alpha-bungarotoxin and similar snake alpha-neurotoxins also targeting alpha7 nAChR. | Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.
Lyukmanova EN, Shulepko MA, Buldakova SL, Kasheverov IE, Shenkarev ZO, Reshetnikov RV, Filkin SY, Kudryavtsev DS, Ojomoko LO, Kryukova EV, Dolgikh DA, Kirpichnikov MP, Bregestovski PD, Tsetlin VI., Free PMC Article | 08/10/2013 |
| Computer modeling, based on ws-LYNX1 NMR structure and AChBP x-ray structure, revealed a possible mode of ws-LYNX1 binding. | NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.
Lyukmanova EN, Shenkarev ZO, Shulepko MA, Mineev KS, D'Hoedt D, Kasheverov IE, Filkin SY, Krivolapova AP, Janickova H, Dolezal V, Dolgikh DA, Arseniev AS, Bertrand D, Tsetlin VI, Kirpichnikov MP., Free PMC Article | 06/18/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| LY-6K meaningfully participates in breast cancer cell metastasis | Metastatic effect of LY-6K gene in breast cancer cells.
Choi SH, Kong HK, Park SY, Park JH. | 01/21/2010 |
| decreased Lynx1 is associated with squamous cell lung carcinoma | Activated cholinergic signaling provides a target in squamous cell lung carcinoma.
Song P, Sekhon HS, Fu XW, Maier M, Jia Y, Duan J, Proskosil BJ, Gravett C, Lindstrom J, Mark GP, Saha S, Spindel ER., Free PMC Article | 01/21/2010 |
| LY-6K,a novel member protein of the Ly-6/uPAR superfamily, is a significant new molecular marker for diagnosis and gene therapy in patients with breast cancer. | LY-6K gene: a novel molecular marker for human breast cancer.
Lee JW, Lee YS, Yoo KH, Lee KH, Park K, Ahn T, Ko C, Park JH. | 01/21/2010 |