| Estrogen-dependent MicroRNA-504 Expression and Related Baroreflex Afferent Neuroexcitation via Negative Regulation on KCNMB4 and KCa1.1 beta4-subunit Expression. | Estrogen-dependent MicroRNA-504 Expression and Related Baroreflex Afferent Neuroexcitation via Negative Regulation on KCNMB4 and KCa1.1 β4-subunit Expression.
Feng Y, Liu Y, Cao PX, Sun X, Li KX, Li XY, Liu L, Wang HD, Cui CP, Xiong X, Zhang HC, Qiao GF, Li BY. | 07/3/2021 |
| Upregulation of Beta4 subunit of BKCa channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors. | Upregulation of Beta4 subunit of BK(Ca) channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors.
Zhao H, Xue Q, Li C, Wang Q, Han S, Zhou Y, Yang T, Xie Y, Fu H, Lu C, Meng F, Zhang M, Zhang Y, Wu X, Wu S, Zhuo M, Xu H., Free PMC Article | 02/6/2021 |
| The results demonstrate a modification in the mitochondrial BKCa channel gating properties in membrane preparations coming from a streptozotocin model of diabetic rats, an effect potentially linked to a change in BKCa beta4 and alpha subunits expression. | Impairment of brain mitochondrial charybdotoxin- and ATP-insensitive BK channel activities in diabetes.
Noursadeghi E, Jafari A, Saghiri R, Sauve R, Eliassi A. | 07/25/2015 |
| Study shows that beta4 subunit of the MaxiK channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability | An endoplasmic reticulum trafficking signal regulates surface expression of β4 subunit of a voltage- and Ca²⁺-activated K⁺ channel.
Cox N, Toro B, Pacheco-Otalora LF, Garrido-Sanabria ER, Zarei MM. | 11/8/2014 |
| BKbeta4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining poassium homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function. | Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKβ1 and BKβ4 in rodent astrocytes.
Seidel KN, Derst C, Salzmann M, Höltje M, Priller J, Markgraf R, Heinemann SH, Heilmann H, Skatchkov SN, Eaton MJ, Veh RW, Prüss H. | 03/31/2012 |
| These results suggest that fast-gating, type I BK channels lacking beta4 can increase neuronal excitability in response to reduced phosphatase activity and activation of calcium channels. | Modulation by the BK accessory β4 subunit of phosphorylation-dependent changes in excitability of dentate gyrus granule neurons.
Petrik D, Wang B, Brenner R., Free PMC Article | 01/28/2012 |
| There is interaction between the mtBK and the mitochondrial permeability transition pore (PTP) in a way that an open mtBK keeps the PTP closed. | Hypoxia increases activity of the BK-channel in the inner mitochondrial membrane and reduces activity of the permeability transition pore.
Cheng Y, Gu XQ, Bednarczyk P, Wiedemann FR, Haddad GG, Siemen D. | 12/12/2011 |
| beta4 subunit is a regulatory component of mitochondrial conductance Ca(2+)-activated potassium channels channels in neurons | Differential distribution of Ca2+-activated potassium channel beta4 subunit in rat brain: immunolocalization in neuronal mitochondria.
Piwonska M, Wilczek E, Szewczyk A, Wilczynski GM. | 01/21/2010 |
| There is a selective distribution of auxiliary beta1 subunits to the somatic and dendritic compartments and beta4 subunits to the terminal compartment of neurons in the hypothalamic-neurohypophysial system. | Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous system.
Wynne PM, Puig SI, Martin GE, Treistman SN., Free PMC Article | 01/21/2010 |
| DiBAC(4)(3) activated whole-cell BKalphabeta1 and BKalphabeta4 currents in the same concentration range but partially blocked BKalphabeta2 currents. Structure activity relationships are discussed. | Voltage-sensitive oxonol dyes are novel large-conductance Ca2+-activated K+ channel activators selective for beta1 and beta4 but not for beta2 subunits.
Morimoto T, Sakamoto K, Sade H, Ohya S, Muraki K, Imaizumi Y. | 01/21/2010 |
| brain BKCa channels are assembled into complexes with calcium channels Cav1.2, Cav2.1 & Cav2.2; complex formation with Cav channels enables BKCa-mediated membrane hyperpolarization controlling neuronal firing & release of hormones & transmitters | BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling.
Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler B. | 01/21/2010 |