Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
Dhavale DD, Barclay AM, Borcik CG, Basore K, Berthold DA, Gordon IR, Liu J, Milchberg MH, O'Shea JY, Rau MJ, Smith Z, Sen S, Summers B, Smith J, Warmuth OA, Perrin RJ, Perlmutter JS, Chen Q, Fitzpatrick JAJ, Schwieters CD, Tajkhorshid E, Rienstra CM, Kotzbauer PT., Free PMC Article

Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications.
Kalyanaraman B, Cheng G, Hardy M., Free PMC Article

Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP.
Oláh J, Norris V, Lehotzky A, Ovádi J., Free PMC Article

Alpha-Synuclein and GM1 Ganglioside Co-Localize in Neuronal Cytosol Leading to Inverse Interaction-Relevance to Parkinson's Disease.
Kumar R, Chowdhury S, Ledeen R., Free PMC Article

Peripheral Upregulation of Parkinson's Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression.
Brazdis RM, von Zimmermann C, Lenz B, Kornhuber J, Mühle C., Free PMC Article

Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein.
Bétemps D, Arsac JN, Nicot S, Canal D, Tlili H, Belondrade M, Morignat E, Verchère J, Gaillard D, Bruyère-Ostells L, Mayran C, Lakhdar L, Bougard D, Baron T., Free PMC Article

Protein-protein interactions regulating α-synuclein pathology.
Wang J, Dai L, Chen S, Zhang Z, Fang X, Zhang Z.

Misfolded alpha-synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment.
Smith R, Hovren H, Bowser R, Bakkar N, Garruto R, Ludolph A, Ravits J, Gaertner L, Murphy D, Lebovitz R.

Molecular Behavior of α-Synuclein Is Associated with Membrane Transport, Lipid Metabolism, and Ubiquitin-Proteasome Pathways in Lewy Body Disease.
Kon T, Lee S, Martinez-Valbuena I, Yoshida K, Tanikawa S, Lang AE, Kovacs GG., Free PMC Article

Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease.
Muwanigwa MN, Modamio-Chamarro J, Antony PMA, Gomez-Giro G, Krüger R, Bolognin S, Schwamborn JC.

Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells.
Nishida S, Matovelo SA, Kajimoto T, Nakamura SI, Okada T.

Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration.
Mahbub NU, Islam MM, Hong ST, Chung HJ., Free PMC Article

A SPLICS reporter reveals [Formula: see text]-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation.
Giamogante F, Barazzuol L, Maiorca F, Poggio E, Esposito A, Masato A, Napolitano G, Vagnoni A, Calì T, Brini M., Free PMC Article

The 75-99 C-Terminal Peptide of URG7 Protein Promotes α-Synuclein Disaggregation.
Dandurand J, Monné M, Samouillan V, Rosa M, Laurita A, Pistone A, Bisaccia D, Matera I, Bisaccia F, Ostuni A., Free PMC Article

Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons.
Santhosh Kumar S, Naseri NN, Pather SR, Hallacli E, Ndayisaba A, Buenaventura C, Acosta K, Roof J, Fazelinia H, Spruce LA, Luk K, Khurana V, Rhoades E, Shalem O., Free PMC Article

Astrocytes and Alpha-Synuclein: Friend or Foe?
Ozoran H, Srinivasan R., Free PMC Article

Disease Mechanisms of Multiple System Atrophy: What a Parallel Between the Form of Pasta and the Alpha-Synuclein Assemblies Involved in MSA and PD Tells Us.
Melki R., Free PMC Article

The contribution of β-amyloid, Tau and α-synuclein to blood-brain barrier damage in neurodegenerative disorders.
Wu YC, Bogale TA, Koistinaho J, Pizzi M, Rolova T, Bellucci A., Free PMC Article

Misfolded α-Synuclein in Autosomal Dominant Alzheimer's Disease.
Fort-Aznar L, Molina-Porcel L, Ramos-Campoy O, Esteller D, Naranjo L, Lladó A, Balasa M, Ruiz-García R, Antonell A, Sánchez-Valle R.

Dopaminergic neuron loss in mice due to increased levels of wild-type human α-Synuclein only takes place under conditions of accelerated aging.
Perez-Villalba A, Sirerol-Piquer MS, Soriano-Cantón R, Folgado V, Pérez-Cañamás A, Kirstein M, Fariñas I, Pérez-Sánchez F., Free PMC Article

MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.
Dorion MF, Yaqubi M, Senkevich K, Kieran NW, MacDonald A, Chen CXQ, Luo W, Wallis A, Shlaifer I, Hall JA, Dudley RWR, Glass IA, Birth Defects Research Laboratory, Stratton JA, Fon EA, Bartels T, Antel JP, Gan-Or Z, Durcan TM, Healy LM., Free PMC Article

Revisiting the role of 3-nitrotyrosine residues in the formation of alpha-synuclein oligomers and fibrils.
Chavarría C, Ivagnes R, Zeida A, Piñeyro MD, Souza JM.

Young human alpha synuclein transgenic (BAC-SNCA) mice display sex- and gene-dose-dependent phenotypic disturbances.
Moceri S, Bäuerle N, Habermeyer J, Ratz-Wirsching V, Harrer J, Distler J, Schulze-Krebs A, Timotius IK, Bluhm A, Hartlage-Rübsamen M, Roßner S, Winkler J, Xiang W, Hörsten SV.

Conformational dynamics of A30G α-synuclein that causes familial Parkinson disease.
Das D, Mattaparthi VSK.

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease.
Yan S, Jiang C, Janzen A, Barber TR, Seger A, Sommerauer M, Davis JJ, Marek K, Hu MT, Oertel WH, Tofaris GK., Free PMC Article