| NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons. | NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons.
Tajima Y, Ito K, Yuan Y, Frank MO, Saito Y, Darnell RB., Free PMC Article | 10/5/2023 |
| Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice. | Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice.
Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S, Cardozo AK, Gurzov EN., Free PMC Article | 10/8/2022 |
| Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis. | Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis.
Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ, Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J, Yeo GW, Winner B., Free PMC Article | 09/10/2022 |
| MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting neuro-oncological ventral antigen 1. | MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting neuro-oncological ventral antigen 1.
Li D, Shen M, Deng X, Bai Y., Free PMC Article | 05/7/2022 |
| a major role for NOVA in regulating cytoskeleton interactions in motoneurons, is reported. | Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons.
Yuan Y, Xie S, Darnell JC, Darnell AJ, Saito Y, Phatnani H, Murphy EA, Zhang C, Maniatis T, Darnell RB., Free PMC Article | 12/22/2018 |
| Together, these results demonstrate that the production of DCC splice variants controlled by NOVA has a crucial function during many stages of commissural neuron development. | NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.
Leggere JC, Saito Y, Darnell RB, Tessier-Lavigne M, Junge HJ, Chen Z., Free PMC Article | 11/18/2017 |
| Phenotypic analysis of the NOVA-deficient mice demonstrated increased adipose tissue thermogenesis and improved glycemia. | An alternative splicing program promotes adipose tissue thermogenesis.
Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ., Free PMC Article | 10/28/2017 |
| RBM4a ablation enhanced the relative level of exon 4-excluded neuro-oncological ventral antigen 1 (Nova1(-4)) transcripts, which were predominantly generated in embryonic BAs | RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes.
Lin JC, Chi YL, Peng HY, Lu YH. | 07/1/2017 |
| identify Nova-1 and hnRNP M as D2R pre-mRNA-binding proteins and show their antagonistic role in the alternative splicing of D2R pre-mRNA. | Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA.
Park E, Iaccarino C, Lee J, Kwon I, Baik SM, Kim M, Seong JY, Son GH, Borrelli E, Kim K., Free PMC Article | 01/28/2012 |
| integrative network revealed combinatorial regulation by Nova and the neuronal splicing factor Fox, interplay between phosphorylation and splicing, and potential links to neurologic disease | Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls.
Zhang C, Frias MA, Mele A, Ruggiu M, Eom T, Marney CB, Wang H, Licatalosi DD, Fak JJ, Darnell RB., Free PMC Article | 08/16/2010 |
| Nova1/Nova2 double knockout mice are paralyzed and fail to cluster AChRs at the neuromuscular junction, and breeding them with transgenic mice constitutively expressing Z(+) agrin in motor neurons rescued AChR clustering | Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.
Ruggiu M, Herbst R, Kim N, Jevsek M, Fak JJ, Mann MA, Fischbach G, Burden SJ, Darnell RB., Free PMC Article | 01/21/2010 |
| Gene silencing and overexpression of the nELAV member HuD in motoneuronal NSC34 cells indicate that Nova1 mRNA stability and translation are positively and strongly controlled by the nELAV proteins | Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV.
Ratti A, Fallini C, Colombrita C, Pascale A, Laforenza U, Quattrone A, Silani V. | 01/21/2010 |
| Assays of splicing intermediates of Nova-regulated transcripts in mouse brain revealed that Nova preferentially regulates removal of introns harbouring (or closest to) YCAY clusters | An RNA map predicting Nova-dependent splicing regulation.
Ule J, Stefani G, Mele A, Ruggiu M, Wang X, Taneri B, Gaasterland T, Blencowe BJ, Darnell RB. | 01/21/2010 |
| These studies demonstrate that in addition to its previously described role as a splicing activator, Nova-1 autoregulates its own expression by acting as a splicing repressor. | Nova autoregulation reveals dual functions in neuronal splicing.
Dredge BK, Stefani G, Engelhard CC, Darnell RB., Free PMC Article | 01/21/2010 |
| CLIP (cross-linking and immunoprecipitation) reveals Nova coordinately regulates a biologically coherent set of RNAs encoding multiple components of the inhibitory synapse, an observation that may relate to the cause of abnormal motor inhibition in POMA | CLIP identifies Nova-regulated RNA networks in the brain.
Ule J, Jensen KB, Ruggiu M, Mele A, Ule A, Darnell RB. | 01/21/2010 |
| Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer | Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer.
Dredge BK, Darnell RB., Free PMC Article | 01/21/2010 |