| PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF[FBXL4]. | PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF(FBXL4).
Nguyen-Dien GT, Townsend B, Kulkarni PG, Kozul KL, Ooi SS, Eldershaw DN, Weeratunga S, Liu M, Jones MJ, Millard SS, Ng DC, Pagano M, Bonfim-Melo A, Schneider T, Komander D, Lazarou M, Collins BM, Pagan JK., Free PMC Article | 08/21/2024 |
| CTCF and BORIS-mediated autophagy regulation via alternative splicing of BNIP3L in breast cancer. | CTCF and BORIS-mediated autophagy regulation via alternative splicing of BNIP3L in breast cancer.
Pandey A, Kakani P, Shukla S., Free PMC Article | 07/29/2024 |
| Association between BCL2 interacting protein 3 like (BNIP3L) genetic polymorphisms and the risk of multiple myeloma in China. | Association between BCL2 interacting protein 3 like (BNIP3L) genetic polymorphisms and the risk of multiple myeloma in China.
Wang Q, Wang Y, Wu J, Xie X, Qin H, Huang C, Li Z, Ling Z, Li R. | 07/18/2024 |
| Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species. | Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species.
Yamashita SI, Sugiura Y, Matsuoka Y, Maeda R, Inoue K, Furukawa K, Fukuda T, Chan DC, Kanki T., | 07/16/2024 |
| Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome. | Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome.
Gao K, Chen Y, Mo R, Wang C., Free PMC Article | 02/14/2024 |
| Uncovering interactions of mitochondrial proteins BNIP3 and BNIP3L with necroptosis-associated kinase RIPK3: Insights into kinase activation. | Uncovering interactions of mitochondrial proteins BNIP3 and BNIP3L with necroptosis-associated kinase RIPK3: Insights into kinase activation.
Luo B, Ming Z. | 08/16/2023 |
| FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels. | FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels.
Elcocks H, Brazel AJ, McCarron KR, Kaulich M, Husnjak K, Mortiboys H, Clague MJ, Urbé S., Free PMC Article | 06/30/2023 |
| The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy. | The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy.
Gok MO, Connor OM, Wang X, Menezes CJ, Llamas CB, Mishra P, Friedman JR., Free PMC Article | 02/22/2023 |
| Mitophagy Effects of Protodioscin on Human Osteosarcoma Cells by Inhibition of p38MAPK Targeting NIX/LC3 Axis. | Mitophagy Effects of Protodioscin on Human Osteosarcoma Cells by Inhibition of p38MAPK Targeting NIX/LC3 Axis.
Huang CF, Hsieh YH, Yang SF, Kuo CH, Wang PH, Liu CJ, Lin RC., Free PMC Article | 02/15/2023 |
| BNIP3 and Nix: Atypical regulators of cell fate. | BNIP3 and Nix: Atypical regulators of cell fate.
Field JT, Gordon JW. | 08/20/2022 |
| BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation. | BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
da Silva Rosa SC, Martens MD, Field JT, Nguyen L, Kereliuk SM, Hai Y, Chapman D, Diehl-Jones W, Aliani M, West AR, Thliveris J, Ghavami S, Rampitsch C, Dolinsky VW, Gordon JW., Free PMC Article | 04/16/2022 |
| A brief overview of BNIP3L/NIX receptor-mediated mitophagy. | A brief overview of BNIP3L/NIX receptor-mediated mitophagy.
Marinković M, Novak I., Free PMC Article | 03/26/2022 |
| NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation. | NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation.
Simpson CL, Tokito MK, Uppala R, Sarkar MK, Gudjonsson JE, Holzbaur ELF., Free PMC Article | 02/5/2022 |
| Expression and Clinical Significance of BCL2 Interacting Protein 3 Like in Multiple Myeloma. | Expression and Clinical Significance of BCL2 Interacting Protein 3 Like in Multiple Myeloma.
Li R, Chen G, Dang Y, He R, Liu A, Ma J, Ling Z., Free PMC Article | 12/18/2021 |
| Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery. | Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery.
Marinković M, Šprung M, Novak I., Free PMC Article | 12/4/2021 |
| NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection. | NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection.
Mahla RS, Kumar A, Tutill HJ, Krishnaji ST, Sathyamoorthy B, Noursadeghi M, Breuer J, Pandey AK, Kumar H. | 11/6/2021 |
| Identification of rare and common variants in BNIP3L: a schizophrenia susceptibility gene. | Identification of rare and common variants in BNIP3L: a schizophrenia susceptibility gene.
Zhou J, Ma C, Wang K, Li X, Jian X, Zhang H, Yuan J, Yin J, Chen J, Shi Y., Free PMC Article | 07/10/2021 |
| Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a. | Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a.
Brennan L, Disatham J, Kantorow M., Free PMC Article | 02/2/2021 |
| [Knockdown of ALAS2 Affects Erythroid Differentiation by Down-regulating Mitophagy Receptor BNIP3L]. | [Knockdown of ALAS2 Affects Erythroid Differentiation by Down-regulating Mitophagy Receptor BNIP3L].
Hu ST, Li XY, Chen H, Xu LH, Fang JP. | 10/24/2020 |
| Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation. | Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation.
Okuyama K, Kitajima Y, Egawa N, Kitagawa H, Ito K, Aishima S, Yanagihara K, Tanaka T, Noshiro H., Free PMC Article | 10/3/2020 |
| NIX-mediated mitophagy is a new oncogenic KRAS effector pathway that suppresses functional mitochondrial content to stimulate cell proliferation and augment redox homeostasis. This pathway promotes the progression of pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDAC) and represents a new dependency in pancreatic cancer. | Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.
Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA., Free PMC Article | 08/13/2020 |
| BNIP3L is a candidate prognostic marker. | BNIP3L Is a New Autophagy Related Prognostic Biomarker for Melanoma Patients Treated With AGI-101H.
Kazimierczak U, Kolenda T, Kowalczyk D, Mackiewicz J, Mackiewicz A. | 07/18/2020 |
| present the results of analysis of BNIP3 and BNIP3L/Nix proteins in cells harboring a combination of the 11778G>A and the 3460G>A Leber's Hereditary Optic Neuropathy mutations | Analysis of BNIP3 and BNIP3L/Nix expression in cybrid cell lines harboring two LHON-associated mutations.
Kodroń A, Hajieva P, Kulicka A, Paterczyk B, Jankauskaite E, Bartnik E. | 06/27/2020 |
| NIX was overexpressed in the pseudopalisading cells that envelop the hypoxic-necrotic regions, and mitochondrial NIX expression was robust in patient-derived glioblastoma tumor tissues and glioblastoma stem cells. NIX was required for hypoxia and oxidative stress-induced mitophagy through NFE2L2/NRF2 transactivation.NIX expression was associated with poor outcome for patients with glioblastoma. | Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma.
Jung J, Zhang Y, Celiku O, Zhang W, Song H, Williams BJ, Giles AJ, Rich JN, Abounader R, Gilbert MR, Park DM., Free PMC Article | 06/6/2020 |
| These data suggest that Nix-dependent mitophagy promotes airway epithelial cell and mitochondria injury induced by cigarette smoke, and may be involved in the pathogenesis of chronic obstructive pulmonary disease and other cigarette smoke-associated diseases | Nix/BNIP3L-dependent mitophagy accounts for airway epithelial cell injury induced by cigarette smoke.
Zhang M, Shi R, Zhang Y, Shan H, Zhang Q, Yang X, Li Y, Zhang J. | 05/30/2020 |