| Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency. | Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency.
Tenorio-Castano J, Gómez ÁS, Coronado M, Rodríguez-Martín P, Parra A, Pascual P, Cazalla M, Gallego N, Arias P, Morales AV, Nevado J, Lapunzina P. | 11/13/2023 |
| EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells. | EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells.
Wang Z, Wei B, Ma S., Free PMC Article | 10/28/2023 |
| circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition. | circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition.
Liang Q, Chu F, Zhang L, Jiang Y, Li L, Wu H., Free PMC Article | 05/17/2023 |
| SOX5 promotes cell growth and migration through modulating the DNMT1/p21 pathway in bladder cancer. | SOX5 promotes cell growth and migration through modulating the DNMT1/p21 pathway in bladder cancer.
Wu L, Yang Z, Dai G, Fan B, Yuan J, Liu Y, Liu P, Ou Z., Free PMC Article | 07/30/2022 |
| LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma. | LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma.
Li Q, Wang W, Yang T, Li D, Huang Y, Bai G, Li Q. | 06/18/2022 |
| miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5. | miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5.
Yang Z, Ren Z, She R, Ao J, Wa Q, Sun Z, Li B, Tian X. | 09/25/2021 |
| LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer. | LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer.
Chen R, Zhang C, Cheng Y, Wang S, Lin H, Zhang H. | 08/28/2021 |
| Clinical spectrum and follow-up in six individuals with Lamb-Shaffer syndrome (SOX5). | Clinical spectrum and follow-up in six individuals with Lamb-Shaffer syndrome (SOX5).
Innella G, Greco D, Carli D, Magini P, Giorgio E, Galesi O, Ferrero GB, Romano C, Brusco A, Graziano C. | 07/10/2021 |
| Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes. | Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes.
Aguennouz M, Guarneri F, Oteri R, Polito F, Giuffrida R, Cannavò SP. | 07/3/2021 |
| High expression levels and localization of Sox5 in dilated cardiomyopathy. | High expression levels and localization of Sox5 in dilated cardiomyopathy.
Liu Y, Jiang B, Cao Y, Chen W, Yin L, Xu Y, Qiu Z., Free PMC Article | 04/13/2021 |
| MicroRNA-15a/16/SOX5 axis promotes migration, invasion and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes. | MicroRNA-15a/16/SOX5 axis promotes migration, invasion and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.
Wei H, Wu Q, Shi Y, Luo A, Lin S, Feng X, Jiang J, Zhang M, Wang F, Tan W., Free PMC Article | 03/27/2021 |
| Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency. | Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency.
Zawerton A, Mignot C, Sigafoos A, Blackburn PR, Haseeb A, McWalter K, Ichikawa S, Nava C, Keren B, Charles P, Marey I, Tabet AC, Levy J, Perrin L, Hartmann A, Lesca G, Schluth-Bolard C, Monin P, Dupuis-Girod S, Guillen Sacoto MJ, Schnur RE, Zhu Z, Poisson A, El Chehadeh S, Alembik Y, Bruel AL, Lehalle D, Nambot S, Moutton S, Odent S, Jaillard S, Dubourg C, Hilhorst-Hofstee Y, Barbaro-Dieber T, Ortega L, Bhoj EJ, Masser-Frye D, Bird LM, Lindstrom K, Ramsey KM, Narayanan V, Fassi E, Willing M, Cole T, Salter CG, Akilapa R, Vandersteen A, Canham N, Rump P, Gerkes EH, Klein Wassink-Ruiter JS, Bijlsma E, Hoffer MJV, Vargas M, Wojcik A, Cherik F, Francannet C, Rosenfeld JA, Machol K, Scott DA, Bacino CA, Wang X, Clark GD, Bertoli M, Zwolinski S, Thomas RH, Akay E, Chang RC, Bressi R, Sanchez Russo R, Srour M, Russell L, Goyette AE, Dupuis L, Mendoza-Londono R, Karimov C, Joseph M, Nizon M, Cogné B, Kuechler A, Piton A, Deciphering Developmental Disorder Study, Klee EW, Lefebvre V, Clark KJ, Depienne C., Free PMC Article | 02/6/2021 |
| NEAT1/miR-193a-3p/SOX5 axis regulates cartilage matrix degradation in human osteoarthritis. | NEAT1/miR-193a-3p/SOX5 axis regulates cartilage matrix degradation in human osteoarthritis.
Liu F, Liu X, Yang Y, Sun Z, Deng S, Jiang Z, Li W, Wu F. | 11/21/2020 |
| Transactivation of SOX5 by Brachyury promotes breast cancer bone metastasis. | Transactivation of SOX5 by Brachyury promotes breast cancer bone metastasis.
Chen M, Zou S, He C, Zhou J, Li S, Shen M, Cheng R, Wang D, Zou T, Yan X, Huang Y, Shen J., Free PMC Article | 10/31/2020 |
| SOX5 is a direct target of miR-497-5P in the non-small-cell lung cancer cells. | miR-497-5p inhibits tumor cell growth and invasion by targeting SOX5 in non-small-cell lung cancer.
Li G, Wang K, Wang J, Qin S, Sun X, Ren H. | 08/13/2020 |
| The expression levels of lncRNA ILF3-AS1 was up-regulated in osteosarcoma tissues and cell lines, and was modulated by SP1. LncRNA ILF3-AS1 promoted osteosarcoma cells proliferation and metastasis via modulation of miR-212-SOX5 pathway. | SP1-mediated upregulation of lncRNA ILF3-AS1 functions a ceRNA for miR-212 to contribute to osteosarcoma progression via modulation of SOX5.
Hu XH, Dai J, Shang HL, Zhao ZX, Hao YD. | 01/25/2020 |
| The results revealed low expression of miR539 and high expression of SOX5 in gastric cancer tissues and cells as compared with the levels in normal tissues and cells, suggesting that there was a negative correlation between miR539 and SOX5. | MicroRNA‑539 inhibits the proliferation and migration of gastric cancer cells by targeting SRY‑box 5 gene.
Ding S, Zhang Y., Free PMC Article | 01/18/2020 |
| Likely pathogenic variants were identified in SOX5 gene, not previously associated with epilepsy, and UBA5, a recently associated with epilepsy gene. | Diagnostic exome sequencing of syndromic epilepsy patients in clinical practice.
Tumienė B, Maver A, Writzl K, Hodžić A, Čuturilo G, Kuzmanić-Šamija R, Čulić V, Peterlin B. | 09/28/2019 |
| Collectively, the rs2477686 in PEX10 , rs6080550 in SIRPA-SIRPG, and rs10842262 in SOX5 gene may indeed be the genetic risk factors for nonobstructive azoospermia (NOA), which requires further investigation using larger independent sets of samples in different ethnic populations. | PEX10, SIRPA-SIRPG, and SOX5 gene polymorphisms are strongly associated with nonobstructive azoospermia susceptibility.
Gu X, Li H, Chen X, Zhang X, Mei F, Jia M, Xiong C., Free PMC Article | 08/31/2019 |
| CircDOCK1 affected the progression of BC via modulation of circDOCK1/hsa-miR-132-3p/Sox5 pathway. | Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa-miR-132-3p/Sox5 signalling pathway.
Liu P, Li X, Guo X, Chen J, Li C, Chen M, Liu L, Zhang X, Zu X., Free PMC Article | 08/3/2019 |
| First reported meta-analysis of genome-wide association study for chronic back pain (CBP) in adults of European ancestry identified novel genetic associations with CBP at SOX5, CCDC26/GSDMC, and DCC.[meta-analysis] | Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain.
Suri P, Palmer MR, Tsepilov YA, Freidin MB, Boer CG, Yau MS, Evans DS, Gelemanovic A, Bartz TM, Nethander M, Arbeeva L, Karssen L, Neogi T, Campbell A, Mellstrom D, Ohlsson C, Marshall LM, Orwoll E, Uitterlinden A, Rotter JI, Lauc G, Psaty BM, Karlsson MK, Lane NE, Jarvik GP, Polasek O, Hochberg M, Jordan JM, Van Meurs JBJ, Jackson R, Nielson CM, Mitchell BD, Smith BH, Hayward C, Smith NL, Aulchenko YS, Williams FMK., Free PMC Article | 01/19/2019 |
| Sox5 is a previously unrecognized regulator of beta-cell gene expression and secretory function | Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.
Axelsson AS, Mahdi T, Nenonen HA, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Szabat M, Tang Y, Wang J, Salö S, Eliasson L, Artner I, Fex M, Johnson JD, Wollheim CB, Derry JMJ, Mecham B, Spégel P, Mulder H, Costa IG, Zhang E, Rosengren AH., Free PMC Article | 12/22/2018 |
| SOX5 overexpression increased Kruppel-like factor 4 (KLF4) gene expression, which was decreased by SOX5 silencing. KLF4 knockdown abrogated the suppressive effect of SOX5 overexpression on osteogenic differentiation of hMSCs. | TNF-α-Induced SOX5 Upregulation Is Involved in the Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Through KLF4 Signal Pathway.
Xu L, Zheng L, Wang Z, Li C, Li S, Xia X, Zhang P, Li L, Zhang L., Free PMC Article | 11/17/2018 |
| Results show that SOX5 expression levels is increased in the synovium of patients with rheumatoid arthritis (RA). Its overexpression regulates the expression of RANKL in RA synovial fibroblasts. | Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5.
Feng X, Shi Y, Xu L, Peng Q, Wang F, Wang X, Sun W, Lu Y, Tsao BP, Zhang M, Tan W., Free PMC Article | 05/19/2018 |
| SOX5, candidate gene, associated with clinical features of Depression (e.g., earlier age at onset and recurrent and more severe forms of Depression). Gene expression patterns in the prefrontal and anterior cingulate cortex most closely matched the genetic findings. | Psychiatric Genomics: An Update and an Agenda.
Sullivan PF, Agrawal A, Bulik CM, Andreassen OA, Børglum AD, Breen G, Cichon S, Edenberg HJ, Faraone SV, Gelernter J, Mathews CA, Nievergelt CM, Smoller JW, O'Donovan MC, Psychiatric Genomics Consortium., Free PMC Article | 02/10/2018 |