| RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition. | RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition.
Dong W, Li X, Cheng L, Yang J, Zhao Z, Qiang X, Li P, Wu J, Guo L. | 04/4/2024 |
| Ribonucleic Acid Export 1 Is a Kinetochore-Associated Protein That Participates in Chromosome Alignment in Mouse Oocytes. | Ribonucleic Acid Export 1 Is a Kinetochore-Associated Protein That Participates in Chromosome Alignment in Mouse Oocytes.
Chen F, Jiao XF, Meng F, Wang YS, Ding ZM, Miao YL, Xiong JJ, Huo LJ., Free PMC Article | 06/19/2021 |
| RAE1 and NUP98 participate inBMAL1 shuttling and promote the degradation and activity of BMAL1 and CLOCK. | RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer.
Zheng X, Zhao X, Zhang Y, Tan H, Qiu B, Ma T, Zeng J, Tao D, Liu Y, Lu Y, Ma Y., Free PMC Article | 04/11/2020 |
| surface NKG2D ligand RAE1epsilon on tumour cells induces CD11b(+) Gr-1(+) myeloid-derived suppressor cell (MDSC) via NKG2D in vitro and in vivo. | NKG2D ligand RAE1ε induces generation and enhances the inhibitor function of myeloid-derived suppressor cells in mice.
Qian L, Liu Y, Wang S, Gong W, Jia X, Liu L, Ye F, Ding J, Xu Y, Fu Y, Tian F., Free PMC Article | 05/5/2018 |
| The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 family of NKG2D ligands. RAE-1 is transcriptionally repressed by histone deacetylase inhibitor 3 (HDAC3) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II and preventing it from activating HDAC3. | A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression.
Greene TT, Tokuyama M, Knudsen GM, Kunz M, Lin J, Greninger AL, DeFilippis VR, DeRisi JL, Raulet DH, Coscoy L., Free PMC Article | 12/16/2017 |
| High RAE1 expression is associated with lymphoma. | CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells.
Sauer M, Schuldner M, Hoffmann N, Cetintas A, Reiners KS, Shatnyeva O, Hallek M, Hansen HP, Gasser S, von Strandmann EP., Free PMC Article | 09/16/2017 |
| Viral infection of cultured cells increased RAE-1 expression, resulting in enhanced NK cell-mediated killing through NKG2D recognition. | Activating receptor NKG2D targets RAE-1-expressing allogeneic neural precursor cells in a viral model of multiple sclerosis.
Weinger JG, Plaisted WC, Maciejewski SM, Lanier LL, Walsh CM, Lane TE., Free PMC Article | 05/23/2015 |
| An increased expression of the NKG2D ligand MICA in systemic lupus erthematosus (SLE) patients' kidneys and Rae-1 and Mult-1 in various murine SLE models, is reported. | NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery.
Spada R, Rojas JM, Pérez-Yagüe S, Mulens V, Cannata-Ortiz P, Bragado R, Barber DF., Free PMC Article | 05/2/2015 |
| Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-gamma in experimental dry eye. | Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-γ in experimental dry eye.
Coursey TG, Bohat R, Barbosa FL, Pflugfelder SC, de Paiva CS., Free PMC Article | 02/28/2015 |
| Highly target-specific liver NKT cells selectively remove activated hepatic stellate cells through an NKG2D-Rae1 interaction to ameliorate liver fibrosis after IL-30 treatment. | IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice.
Mitra A, Satelli A, Yan J, Xueqing X, Gagea M, Hunter CA, Mishra L, Li S., Free PMC Article | 02/14/2015 |
| Results suggest that genomic damage in tumor cells leads to activation of STING-dependent DNA sensor pathways, thereby activating RAE1 and enabling tumor immunosurveillance. | RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma.
Lam AR, Bert NL, Ho SS, Shen YJ, Tang LF, Xiong GM, Croxford JL, Koo CX, Ishii KJ, Akira S, Raulet DH, Gasser S., Free PMC Article | 07/26/2014 |
| GM-SCF, IL-21 and Rae1 expression, alone or in combination, induces a cellular immune response against H22 tumor cells. | Activation of cellular immunity and marked inhibition of liver cancer in a mouse model following gene therapy and tumor expression of GM-SCF, IL-21, and Rae-1.
Cheng M, Zhi K, Gao X, He B, Li Y, Han J, Zhang Z, Wu Y., Free PMC Article | 07/12/2014 |
| mouse cytomegalovirus m152/gp40 interaction with RAE1gamma structural analysis reveals a paradigm for MHC/MHC interaction in immune evasion | Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1γ reveals a paradigm for MHC/MHC interaction in immune evasion.
Wang R, Natarajan K, Revilleza MJ, Boyd LF, Zhi L, Zhao H, Robinson H, Margulies DH., Free PMC Article | 03/2/2013 |
| Expression of RAE-1 proteins on erythroblast surfaces increased early after Friend virus inoculation and infected erythroid cells are recognized by natural killer cells mainly through the NKG2D-RAE-1 interactions in vivo. | Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In Vivo.
Ogawa T, Tsuji-Kawahara S, Yuasa T, Kinoshita S, Chikaishi T, Takamura S, Matsumura H, Seya T, Saga T, Miyazawa M., Free PMC Article | 07/16/2011 |
| NKG2D/Rae1 interaction is involved in the synergic effects of NK cells and Kupffer cells on acute liver injury. | NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis.
Hou X, Zhou R, Wei H, Sun R, Tian Z. | 01/21/2010 |
| Blocking RA synthesis by the Raldh inhibitor or blocking retinoic acid signaling by the retinoic acid receptor antagonist abolished upregulation of RAE-1. RA stimulates RAE1 expression and sensitizes early activated HSCs to NK cell killing. | Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1.
Radaeva S, Wang L, Radaev S, Jeong WI, Park O, Gao B. | 01/21/2010 |
| VSV M protein blocks mRNA export by disrupting Rae1 function, which can be reverted by induction of Rae1 expression. | VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway.
Faria PA, Chakraborty P, Levay A, Barber GN, Ezelle HJ, Enninga J, Arana C, van Deursen J, Fontoura BM. | 01/21/2010 |
| Hepatic ischemia/reperfusion injury increrases gene expression. | Yisheng injection decreases the expression of H60 and RAE-1 genes in ischemic mice liver.
Cheng F, Feng L, Li S, Tan J, Cao L, He Y, Ye Z, Li Y. | 01/21/2010 |
| In kidney reperfusion injury, there is a higher rats of mRNA espression | The effect of renal ischemia-reperfusion injury on expression of RAE-1 and H60 in mice kidney.
Feng L, Cheng F, Ye Z, Li S, He Y, Yao X, Tang Q, Li Y. | 01/21/2010 |
| results suggest that Rae1 and Nup98 are temporal regulators of APC(Cdh1) that maintain euploidy by preventing unscheduled degradation of securin | The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.
Jeganathan KB, Malureanu L, van Deursen JM. | 01/21/2010 |