| Spatiotemporal expression and coexpression patterns of SRPK1 in the human brain: A neurodevelopmental perspective. | Spatiotemporal expression and coexpression patterns of SRPK1 in the human brain: A neurodevelopmental perspective.
Wang JJ, Roy SK, Xu YM., Free PMC Article | 03/27/2024 |
| Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3beta Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer. | Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3β Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer.
Huang JQ, Duan LX, Liu QY, Li HF, Hu AP, Song JW, Lin C, Huang B, Yao D, Peng B, Sun Y, Wen Y, Yang L, Xu X, Gong LY., Free PMC Article | 04/10/2023 |
| SRPK1 promotes sepsis-induced acute lung injury via regulating PI3K/AKT/FOXO3 signaling. | SRPK1 promotes sepsis-induced acute lung injury via regulating PI3K/AKT/FOXO3 signaling.
Guo W, Hu Z. | 03/28/2023 |
| Inhibition of SRPK1, a key splicing regulator, exhibits antitumor and chemotherapeutic-sensitizing effects on extranodal NK/T-cell lymphoma cells. | Inhibition of SRPK1, a key splicing regulator, exhibits antitumor and chemotherapeutic-sensitizing effects on extranodal NK/T-cell lymphoma cells.
He C, Liu B, Wang HY, Wu L, Zhao G, Huang C, Liu Y, Shan B, Liu L., Free PMC Article | 11/5/2022 |
| SRPK1 promotes cell proliferation and tumor growth of osteosarcoma through activation of the NF-kappaB signaling pathway. | SRPK1 promotes cell proliferation and tumor growth of osteosarcoma through activation of the NF-κB signaling pathway.
Gong Y, Yang C, Wei Z, Liu J. | 06/18/2022 |
| Increased expression of SRPK1 (serine/arginine-rich protein-specific kinase 1) is associated with progression and unfavorable prognosis in cervical squamous cell carcinoma. | Increased expression of SRPK1 (serine/arginine-rich protein-specific kinase 1) is associated with progression and unfavorable prognosis in cervical squamous cell carcinoma.
Dong Z, Chang X, Xie L, Wang Y, Hou Y., Free PMC Article | 04/23/2022 |
| miR-150 and SRPK1 regulate AKT3 expression to participate in LPS-induced inflammatory response. | miR-150 and SRPK1 regulate AKT3 expression to participate in LPS-induced inflammatory response.
Yao Y, Wang H, Xi X, Sun W, Ge J, Li P., Free PMC Article | 01/29/2022 |
| LINC00473 protects against cerebral ischemia reperfusion injury via sponging miR-15b-5p and miR-15a-5p to regulate SRPK1 expression. | LINC00473 protects against cerebral ischemia reperfusion injury via sponging miR-15b-5p and miR-15a-5p to regulate SRPK1 expression.
Yao B, Ye L, Chen J, Zhuo S, Lin H. | 01/8/2022 |
| SRPK1/2 and PP1alpha exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma. | SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.
Liu H, Gong Z, Li K, Zhang Q, Xu Z, Xu Y., Free PMC Article | 10/23/2021 |
| Nuclear Translocation of SRPKs Is Associated with 5-FU and Cisplatin Sensitivity in HeLa and T24 Cells. | Nuclear Translocation of SRPKs Is Associated with 5-FU and Cisplatin Sensitivity in HeLa and T24 Cells.
Sigala I, Koutroumani M, Koukiali A, Giannakouros T, Nikolakaki E., Free PMC Article | 10/23/2021 |
| Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene. | Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene.
Heft Neal ME, Birkeland AC, Bhangale AD, Zhai J, Kulkarni A, Foltin SK, Jewell BM, Ludwig ML, Pinatti L, Jiang H, McHugh JB, Marentette L, McKean EL, Brenner JC., Free PMC Article | 10/16/2021 |
| A HIF1A/miR-485-5p/SRPK1 axis modulates the aggressiveness of glioma cells upon hypoxia. | A HIF1A/miR-485-5p/SRPK1 axis modulates the aggressiveness of glioma cells upon hypoxia.
Cheng L, Peng R, Guo P, Zhang H, Liu D, Liao X, Liu Y, Mo X, Liao Y. | 09/25/2021 |
| SRPK1 acetylation modulates alternative splicing to regulate cisplatin resistance in breast cancer cells. | SRPK1 acetylation modulates alternative splicing to regulate cisplatin resistance in breast cancer cells.
Wang C, Zhou Z, Subhramanyam CS, Cao Q, Heng ZSL, Liu W, Fu X, Hu Q., Free PMC Article | 06/19/2021 |
| A conserved sequence motif bridges two protein kinases for enhanced phosphorylation and nuclear function of a splicing factor. | A conserved sequence motif bridges two protein kinases for enhanced phosphorylation and nuclear function of a splicing factor.
Aubol BE, Fattet L, Adams JA. | 06/19/2021 |
| WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1. | WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1.
Belali T, Wodi C, Clark B, Cheung MK, Craig TJ, Wheway G, Wagner N, Wagner KD, Roberts S, Porazinski S, Ladomery M. | 02/6/2021 |
| Human papillomavirus type 16 infection activates the host serine arginine protein kinase 1 (SRPK1) - splicing factor axis. | Human papillomavirus type 16 infection activates the host serine arginine protein kinase 1 (SRPK1) - splicing factor axis.
Mole S, Faizo AAA, Hernandez-Lopez H, Griffiths M, Stevenson A, Roberts S, Graham SV., Free PMC Article | 10/31/2020 |
| Serine-Arginine Protein Kinase 1 Regulates Ebola Virus Transcription. | Serine-Arginine Protein Kinase 1 Regulates Ebola Virus Transcription.
Takamatsu Y, Krähling V, Kolesnikova L, Halwe S, Lier C, Baumeister S, Noda T, Biedenkopf N, Becker S., Free PMC Article | 08/29/2020 |
| Serine-Arginine Protein Kinase 1 (SRPK1) as a Prognostic Factor and Potential Therapeutic Target in Cancer: Current Evidence and Future Perspectives. | Serine-Arginine Protein Kinase 1 (SRPK1) as a Prognostic Factor and Potential Therapeutic Target in Cancer: Current Evidence and Future Perspectives.
Nikas IP, Themistocleous SC, Paschou SA, Tsamis KI, Ryu HS., Free PMC Article | 08/29/2020 |
| These results suggested that SRPK1 contributes to gastric cancer development by a new possible mechanism involving small nucleolar RNA mediated signaling | SRPK1 facilitates tumor cell growth via modulating the small nucleolar RNA expression in gastric cancer.
Li Y, Yu S, Wang X, Ye X, He B, Quan M, Gao Y. | 05/30/2020 |
| SRPK1 inhibition produces a significant switch from the short to the long BRD4 isoform at the mRNA and protein levels. | SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML, Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C, Bradley A, Jeremias I, Bates DO, Yusa K, Kouzarides T, Vassiliou GS., Free PMC Article | 02/16/2019 |
| We now show that the ability of SRPK1 to mobilize SRSF1 from speckles to the nucleoplasm is dependent on active CLK1. Diffusion from speckles is promoted by the formation of an SRPK1-CLK1 complex that facilitates dissociation of SRSF1 from CLK1 and enhances the phosphorylation of several serine-proline dipeptides in this SR protein | Mobilization of a splicing factor through a nuclear kinase-kinase complex.
Aubol BE, Keshwani MM, Fattet L, Adams JA., Free PMC Article | 09/15/2018 |
| SRPK1 is a direct target of miR-1296 in the epatocellular carcinoma. | MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway.
Xu Q, Liu X, Liu Z, Zhou Z, Wang Y, Tu J, Li L, Bao H, Yang L, Tu K., Free PMC Article | 08/18/2018 |
| knockdown of the SRPK1 gene by RNAi inhibits the proliferation of K562 cells and induces apoptosis. | SRPK1‑siRNA suppresses K562 cell growth and induces apoptosis via the PARP‑caspase3 pathway.
Wang H, Ge W, Jiang W, Li D, Ju X. | 07/14/2018 |
| Findings suggest MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in CRC cells. These results reveal a novel molecular mechanism by which MALAT1 regulates AKAP-9 expression in CRC cells. | Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal cancer cells.
Hu ZY, Wang XY, Guo WB, Xie LY, Huang YQ, Liu YP, Xiao LW, Li SN, Zhu HF, Li ZG, Kan H., Free PMC Article | 12/2/2017 |
| The frameshift mutation detected in the current study would result in premature stops of amino acid synthesis in PLA2R1 and SRPK1 proteins and hence resembles a typical inactivating mutation. | Inactivating frameshift mutation of putative tumor suppressor genes PLA2R1 and SRPK1 in gastric and colorectal cancers.
Lee JH, Jo YS, Kim MS, Yoo NJ, Lee SH. | 11/11/2017 |