| IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus. | IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus.
Song Y, Wei F, Liu Y, Han F, Ma L, Zhuang Y, Pan C, Jia Z, Gong A., Free PMC Article | 08/6/2022 |
| Identification of a unique anti-Ro60 subset with restricted serological and molecular profiles. | Identification of a unique anti-Ro60 subset with restricted serological and molecular profiles.
Lee AYS, Beroukas D, Brown L, Lucchesi C, Kaur A, Gyedu L, Hughes N, Ng YH, Saran O, Gordon TP, Wang JJ., Free PMC Article | 07/31/2021 |
| Noncoding Y RNAs regulate the levels, subcellular distribution and protein interactions of their Ro60 autoantigen partner. | Noncoding Y RNAs regulate the levels, subcellular distribution and protein interactions of their Ro60 autoantigen partner.
Leng Y, Sim S, Magidson V, Wolin SL., Free PMC Article | 09/12/2020 |
| Because the Ro60 ribonucleoprotein (RNP) is a clinically important target of autoantibodies in patients with rheumatic diseases such as Sjogren's syndrome, systemic lupus erythematosus, and neonatal lupus, this review discusses potential roles for Ro60 RNPs in the initiation and pathogenesis of systemic autoimmune rheumatic disease. [review] | Ro60 and Y RNAs: structure, functions, and roles in autoimmunity.
Boccitto M, Wolin SL., Free PMC Article | 02/15/2020 |
| strengthens the anti-inflammatory effect via macrophage polarization by estrogen induction in abdominal aortic aneurysm | TROVE2 strengthens the anti-inflammatory effect via macrophage polarization by estrogen induction in abdominal aortic aneurysm.
Chen S, Zhao Y, Jin H, Qi X, He J, Huang J, Ding Y, Chen W, Wu C, Ding X, Chen S, Zhang H, Shang Y, Du D, Zhao J. | 02/1/2020 |
| TROVE2 is a novel target of miR-128 in astrocytoma tissues and the expression of TROVE2 is increased with the pathological stages increasing. | Expression Profile of MiR-128 in the Astrocytoma Patients and Cell Lines.
Xu J, Liu Y, Guo S, Ma S, Xiao L, Wei N, Xue R. | 01/20/2018 |
| Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 and anti-La. | Association of anti-Ro52, anti-Ro60 and anti-La antibodies with diagnostic, clinical and laboratory features in a referral hospital in Jerez, Spain.
Menor Almagro R, Jurado Roger A, Rodríguez Gutiérrez FJ, Solís Díaz R, Cardiel MH, Salaberri Maestrojuan JJ. | 04/29/2017 |
| These findings establish a link among the lupus autoantigen Ro60, Alu retroelements, and type I interferon. | The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.
Hung T, Pratt GA, Sundararaman B, Townsend MJ, Chaivorapol C, Bhangale T, Graham RR, Ortmann W, Criswell LA, Yeo GW, Behrens TW., Free PMC Article | 04/2/2016 |
| Findings indicate a relentless turnover of short-lived clonotypic variants, masquerading as long-lived Ro60 humoral autoimmunity. | Long-term Ro60 humoral autoimmunity in primary Sjögren's syndrome is maintained by rapid clonal turnover.
Lindop R, Arentz G, Bastian I, Whyte AF, Thurgood LA, Chataway TK, Jackson MW, Gordon TP. | 11/16/2013 |
| The Y3 RNA moiety of the Ro60 ribonucleoprotein plays a critical role in the pathogenesis of fetal cardiac injury by altering the subcellular location of Ro60 autoantibodies. | Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus.
Reed JH, Sim S, Wolin SL, Clancy RM, Buyon JP., Free PMC Article | 09/21/2013 |
| these data indicate that ZBP1 may function as an adapter to export the Ro/Y3 RNA complex from nuclei. | The zipcode-binding protein ZBP1 influences the subcellular location of the Ro 60-kDa autoantigen and the noncoding Y3 RNA.
Sim S, Yao J, Weinberg DE, Niessen S, Yates JR 3rd, Wolin SL., Free PMC Article | 02/11/2012 |
| conclude that RNPs containing hY RNAs and Ro60, La or nucleolin are not required for the function of hY RNAs in chromosomal DNA replication in a human cell-free system, which can be mediated by Y RNAs outside of these RNPs | Ribonucleoprotein particles containing non-coding Y RNAs, Ro60, La and nucleolin are not required for Y RNA function in DNA replication.
Langley AR, Chambers H, Christov CP, Krude T., Free PMC Article | 03/12/2011 |
| 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity | 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity.
Heinlen LD, McClain MT, Ritterhouse LL, Bruner BF, Edgerton CC, Keith MP, James JA, Harley JB., Free PMC Article | 01/15/2011 |
| dichotomy of human autoantibody responses against mutually exclusive determinants linked to a single domain of a systemic autoantigen and supports a model in which tolerance is broken by different immunogenic forms of Ro 60 | Reactivity with dichotomous determinants of Ro 60 stratifies autoantibody responses in lupus and primary Sjögren's syndrome.
Reed JH, Dudek NL, Osborne SE, Kaufman KM, Jackson MW, Purcell AW, Gordon TP. | 06/28/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| Activation of Toll-like receptors by fetal factor Ro60-associated single-stranded RNA particles is relevant in autoimmune-associated congenital heart block, where the obligate maternal factor is an anti-SSA/Ro autoantibody. | Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block.
Clancy RM, Alvarez D, Komissarova E, Barrat FJ, Swartz J, Buyon JP., Free PMC Article | 03/29/2010 |
| results demonstrate that Ro 60 functions as a novel receptor for beta(2)GPI on the surface of apoptotic cells. The formation of Ro 60-beta(2)GPI complexes may protect against anti-Ro 60 autoantibody-mediated tissue injury. | Ro 60 functions as a receptor for beta(2)-glycoprotein I on apoptotic cells.
Reed JH, Giannakopoulos B, Jackson MW, Krilis SA, Gordon TP. | 01/21/2010 |
| interactions between Ro-Y5 and L5-5S RNPs establish 5S RNA as a target of quality control | Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control.
Hogg JR, Collins K., Free PMC Article | 01/21/2010 |
| Increased Ro/SSA 60 and La/SSB mRNA expression in minor salivary glands in primary Sjogren's syndrome (pSS) suggest that these 2 autoantigens, but not Ro/SSA 52, are involved in tissue-specific autoimmune response in pSS. | Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA 52 kDa, mRNA and protein in minor salivary glands from patients with primary Sjögren's syndrome.
Barcellos KS, Nonogaki S, Enokihara MM, Teixeira MS, Andrade LE. | 01/21/2010 |
| In viitro RNA chaperone activity of SSA2 was studied. | RNA chaperone activity of protein components of human Ro RNPs.
Belisova A, Semrad K, Mayer O, Kocian G, Waigmann E, Schroeder R, Steiner G., Free PMC Article | 01/21/2010 |
| The structural organization and Zn2+-dependent subdomain interactions involving autoiantigenic epitopes in the RBBC region of SS-A were studied. | Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52.
Hennig J, Ottosson L, Andrésen C, Horvath L, Kuchroo VK, Broo K, Wahren-Herlenius M, Sunnerhagen M. | 01/21/2010 |