| Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia. | Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
Suske T, Sorger H, Manhart G, Ruge F, Prutsch N, Zimmerman MW, Eder T, Abdallah DI, Maurer B, Wagner C, Schönefeldt S, Spirk K, Pichler A, Pemovska T, Schweicker C, Pölöske D, Hubanic E, Jungherz D, Müller TA, Aung MMK, Orlova A, Pham HTT, Zimmel K, Krausgruber T, Bock C, Müller M, Dahlhoff M, Boersma A, Rülicke T, Fleck R, de Araujo ED, Gunning PT, Aittokallio T, Mustjoki S, Sanda T, Hartmann S, Grebien F, Hoermann G, Haferlach T, Staber PB, Neubauer HA, Look AT, Herling M, Moriggl R., Free PMC Article | 04/18/2024 |
| PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry. | PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry.
Li CF, Chan TC, Fang FM, Yu SC, Huang HY., Free PMC Article | 08/16/2023 |
| Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer. | Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer.
Li J, Li L, Mahesutihan G, Meng J, Chen Y, Lv J., Free PMC Article | 03/10/2023 |
| STAT5b: A master regulator of key biological pathways. | STAT5b: A master regulator of key biological pathways.
Smith MR, Satter LRF, Vargas-Hernández A., Free PMC Article | 02/13/2023 |
| STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis. | STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis.
Pelham SJ, Caldirola MS, Avery DT, Mackie J, Rao G, Gothe F, Peters TJ, Guerin A, Neumann D, Vokurkova D, Hwa V, Zhang W, Lyu SC, Chang I, Manohar M, Nadeau KC, Gaillard MI, Bezrodnik L, Iotova V, Zwirner NW, Gutierrez M, Al-Herz W, Goodnow CC, Vargas-Hernández A, Forbes Satter LR, Hambleton S, Deenick EK, Ma CS, Tangye SG. | 10/15/2022 |
| Identification of novel STAT5B mutations and characterization of TCRbeta signatures in CD4+ T-cell large granular lymphocyte leukemia. | Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia.
Bhattacharya D, Teramo A, Gasparini VR, Huuhtanen J, Kim D, Theodoropoulos J, Schiavoni G, Barilà G, Vicenzetto C, Calabretto G, Facco M, Kawakami T, Nakazawa H, Falini B, Tiacci E, Ishida F, Semenzato G, Kelkka T, Zambello R, Mustjoki S., Free PMC Article | 05/14/2022 |
| miR-146a enhances regulatory T-cell differentiation and function in allergic rhinitis by targeting STAT5b. | miR-146a enhances regulatory T-cell differentiation and function in allergic rhinitis by targeting STAT5b.
Zhang Y, Yang Y, Guo J, Cui L, Yang L, Li Y, Mou Y, Jia C, Zhang L, Song X. | 04/16/2022 |
| Developmental Adaptive Immune Defects Associated with STAT5B Deficiency in Three Young Siblings. | Developmental Adaptive Immune Defects Associated with STAT5B Deficiency in Three Young Siblings.
Foley CL, Al Remeithi SS, Towe CT, Dauber A, Backeljauw PF, Tyzinski L, Kumar AR, Hwa V., Free PMC Article | 01/15/2022 |
| Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways. | Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.
Bonaccorso P, Bugarin C, Buracchi C, Fazio G, Biondi A, Lo Nigro L, Gaipa G. | 08/21/2021 |
| MKL-1 is a coactivator for STAT5b, the regulator of Treg cell development and function. | MKL-1 is a coactivator for STAT5b, the regulator of Treg cell development and function.
Xiang Y, Wang J, Li JP, Guo W, Huang F, Zhang HM, Li HH, Dai ZT, Zhang ZJ, Li H, Bao LY, Gu CJ, Chen K, Zhang TC, Liao XH., Free PMC Article | 08/14/2021 |
| Human growth disorders associated with impaired GH action: Defects in STAT5B and JAK2. | Human growth disorders associated with impaired GH action: Defects in STAT5B and JAK2.
Hwa V., Free PMC Article | 07/31/2021 |
| STAT3 and STAT5B mutations have unique distribution in T-cell large granular lymphocyte proliferations and advanced myeloid neoplasms. | STAT3 and STAT5B mutations have unique distribution in T-cell large granular lymphocyte proliferations and advanced myeloid neoplasms.
Qu S, Jia Y, Wang H, Ai X, Xu Z, Qin T, Pan L, Li B, Huang G, Gale RP, Xiao Z., Free PMC Article | 07/17/2021 |
| Inactivated STAT5 pathway underlies a novel inhibitory role of EBF1 in chronic lymphocytic leukemia. | Inactivated STAT5 pathway underlies a novel inhibitory role of EBF1 in chronic lymphocytic leukemia.
Wang C, Li L, Li M, Shen X, Liu Y, Wang S. | 05/1/2021 |
| Optimization of a high-throughput fluorescence polarization assay for STAT5B DNA binding domain-targeting inhibitors. | Optimization of a high-throughput fluorescence polarization assay for STAT5B DNA binding domain-targeting inhibitors.
Manaswiyoungkul P, Erdogan F, Olaoye OO, Cabral AD, de Araujo ED, Gunning PT. | 01/23/2021 |
| Does acute promyelocytic leukemia patient with the STAT5B/RARa fusion gene respond well to decitabine?: A case report and literature review. | Does acute promyelocytic leukemia patient with the STAT5B/RARa fusion gene respond well to decitabine?: A case report and literature review.
Wang L, Yan X, He J., Free PMC Article | 11/21/2020 |
| Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer. | Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.
Erb HHH, Bodenbender J, Handle F, Diehl T, Donix L, Tsaur I, Gleave M, Haferkamp A, Huber J, Fuessel S, Juengel E, Culig Z, Thomas C., Free PMC Article | 10/10/2020 |
| ATP Inhibits the Transcription Factor STAT5b. | ATP Inhibits the Transcription Factor STAT5b.
Berg A, Sperl B, Berg T. | 09/12/2020 |
| results show that in addition to the impaired terminal maturation of NK cells, human STAT5b mutation leads to impairments in early activation events in NK cell lytic synapse formation. | Human signal transducer and activator of transcription 5b (STAT5b) mutation causes dysregulated human natural killer cell maturation and impaired lytic function.
Vargas-Hernández A, Witalisz-Siepracka A, Prchal-Murphy M, Klein K, Mahapatra S, Al-Herz W, Mace EM, Carisey AF, Orange JS, Sexl V, Forbes LR., Free PMC Article | 08/1/2020 |
| High STAT5B expression is associated with imatinib resistance in chronic myeloid leukemia. | MicroRNA-221 sensitizes chronic myeloid leukemia cells to imatinib by targeting STAT5.
Jiang X, Cheng Y, Hu C, Zhang A, Ren Y, Xu X. | 08/1/2020 |
| STAT5 refer to STAT5A and STAT5B, however they have might have different role in hematopoietic stem cells or in Chronic myeloid leukemia cells. [review] | The Role of STAT5 in Tyrosine Kinase Inhibitor (IMATINIB) Resistance in CML Patients.
Putri A, Rinaldi I, Louisa M, Koesnoe S. | 07/25/2020 |
| altered IL-2-mediated STAT-5 phosphorylation within individual circulatory CD8+CD25+ Tregs may be associated with asthma and disease severity | Interleukin-2-mediated stat-5 expression levels in CD8+CD25+ regulatory T cells: the relevance for asthma.
Eusebio M, Kraszula L, Kupczyk M, Kuna P, Pietruczuk M. | 02/8/2020 |
| STAT5BN642H, are associated with aggressive forms of CD56+ T cell (NKT). | STAT5B(N642H) drives transformation of NKT cells: a novel mouse model for CD56(+) T-LGL leukemia.
Klein K, Witalisz-Siepracka A, Maurer B, Prinz D, Heller G, Leidenfrost N, Prchal-Murphy M, Suske T, Moriggl R, Sexl V., Free PMC Article | 02/8/2020 |
| Signal transducer and activator of transcription 5B deficiency due to a novel missense mutation in the coiled-coil domain. | Signal transducer and activator of transcription 5B deficiency due to a novel missense mutation in the coiled-coil domain.
Acres MJ, Gothe F, Grainger A, Skelton AJ, Swan DJ, Willet JDP, Leech S, Galcheva S, Iotova V, Hambleton S, Engelhardt KR., Free PMC Article | 11/16/2019 |
| STAT5B promoted cell proliferation and drug resistance in human Mantle cell lymphoma cells by activating the Akt signaling pathway. | The Signal Transducer and Activator of Transcription 5B (STAT5B) Gene Promotes Proliferation and Drug Resistance of Human Mantle Cell Lymphoma Cells by Activating the Akt Signaling Pathway.
Zhang W, Liang X, Gong Y, Xiao C, Guo B, Yang T., Free PMC Article | 08/3/2019 |
| Herein, we emphasize the aggressive nature of STAT5B(N642H) in driving T-cell neoplasia upon hematopoietic expression in transgenic mice, revealing evidence of multiple T-cell subset organ infiltration. Notably, we demonstrate STAT5B(N642H)-driven transformation of gammadelta T-cells in in vivo syngeneic transplant models, comparable to STAT5B(N642H) patient gammadelta T-cell entities. | Structural and functional consequences of the STAT5B(N642H) driver mutation.
de Araujo ED, Erdogan F, Neubauer HA, Meneksedag-Erol D, Manaswiyoungkul P, Eram MS, Seo HS, Qadree AK, Israelian J, Orlova A, Suske T, Pham HTT, Boersma A, Tangermann S, Kenner L, Rülicke T, Dong A, Ravichandran M, Brown PJ, Audette GF, Rauscher S, Dhe-Paganon S, Moriggl R, Gunning PT., Free PMC Article | 06/22/2019 |