| Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity. | Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
Toth D, Dudas B, Miteva MA, Balog E., Free PMC Article | 12/20/2023 |
| Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations. | Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations.
Dudas B, Toth D, Perahia D, Nicot AB, Balog E, Miteva MA., Free PMC Article | 11/6/2021 |
| Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function. | Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
Idris M, Mitchell DJ, Gordon R, Sidharthan NP, Butcher NJ, Minchin RF. | 07/24/2021 |
| Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan. | Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan.
Aversa J, Song M, Shimazu T, Inoue M, Charvat H, Yamaji T, Sawada N, Pfeiffer RM, Karimi P, Dawsey SM, Rabkin CS, Tsugane S, Camargo MC. | 03/13/2021 |
| Investigating the molecular mechanism of hydroxylated bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase SULT1A1. | Investigating the molecular mechanism of hydroxylated bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase SULT1A1.
Ma G, Geng L, Lu Y, Wei X, Yu H. | 12/26/2020 |
| Evaluation of a conserved tryptophanyl residue in donor substrate binding and catalysis by a phenol sulfotransferase (SULT1A1). | Evaluation of a conserved tryptophanyl residue in donor substrate binding and catalysis by a phenol sulfotransferase (SULT1A1).
Beckmann JD, Chodavarapu S, Doyle B. | 12/12/2020 |
| These findings highlight the key insights of structural consequences caused by R213H mutation, which would enrich the understanding regarding the role of SULT1A1 mutation in cancer development. | Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding.
Dash R, Ali MC, Dash N, Azad MAK, Hosen SMZ, Hannan MA, Moon IS., Free PMC Article | 04/25/2020 |
| Different ethnic and racial populations have varying degrees of SULT1A1-mediated sulfation activity. | Multi-ethnic SULT1A1 copy number profiling with multiplex ligation-dependent probe amplification.
Vijzelaar R, Botton MR, Stolk L, Martis S, Desnick RJ, Scott SA., Free PMC Article | 03/23/2019 |
| Patients were categorized in three groups depending on the decreased SULT1A1 activity due to rs6839 and rs1042157: low activity group (rs6839 (GG) and rs1042157 (TT)); high activity group (rs6839 (AA) and rs1042157 (CC)); and medium activity group (all the other combinations of rs6839 and rs1042157). Associations between SULT1A1 phenotypes and clinical outcome (RFS) were explored | Genetic polymorphisms of 3'-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy.
Sanchez-Spitman AB, Dezentjé VO, Swen JJ, Moes DJAR, Gelderblom H, Guchelaar HJ., Free PMC Article | 01/12/2019 |
| Suggest SULT1A1/1A2 play a central role in furfuryl alcohol bioactivation and the formation of hemoglobin adducts. | Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.
Monien BH, Sachse B, Meinl W, Abraham K, Lampen A, Glatt H. | 09/1/2018 |
| SULT1A1 Arg213His (rs9282861) polymorphism might be associated with breast cancer risk, especially among Asian population. | Association between SULT1A1 Arg213His (rs9282861) Polymorphism and Risk of Breast Cancer: A Systematic Review and Meta-Analysis.
Forat-Yazdi M, Jafari M, Kargar S, Abolbaghaei SM, Nasiri R, Farahnak S, Foroughi E, Neamatzadeh H. | 08/11/2018 |
| No significant difference was observed in the RNA levels of CYP1A1 and SULT1A1 between the two groups. The frequency of expression of the CYP17 T/C variant tended to be higher and the A allele of COMT polymorphism together with down-regulation of its mRNA expression may be more frequent in Chinese women with idiopathic POI | The significance of polymorphism and expression of oestrogen metabolism-related genes in Chinese women with premature ovarian insufficiency.
Qin C, Chen Y, Lin Q, Yao J, Wu W, Xie J. | 08/4/2018 |
| The importance of SULT1A1 genotype for hepatic methyleugenol DNA adducts in humans, and a strong impact of SULT1A1 copy number variations on SULT1A1 hepatic phenotype. | Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels.
Tremmel R, Herrmann K, Engst W, Meinl W, Klein K, Glatt H, Zanger UM. | 07/21/2018 |
| SULT1A1 role in the metabolic detoxification of heterocyclic aromatic amines | Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells.
Chevereau M, Glatt H, Zalko D, Cravedi JP, Audebert M. | 07/21/2018 |
| Silencing the SULT1A1 gene led to changes in resveratrol metabolism, with higher intracellular accumulation of the nonmetabolized resveratrol. | Role of sulfotransferases in resveratrol metabolism in human adipocytes.
Gheldof N, Moco S, Chabert C, Teav T, Barron D, Hager J. | 07/7/2018 |
| the NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism combination with smoking significantly confer susceptibility to BC. [META-ANALYSIS] | Combined effects of NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism and smoking on bladder cancer risk: Two meta-analyses.
Wang XC, Wang J, Tao HH, Zhang C, Xu LF. | 03/17/2018 |
| SULT1A1 gene copy number affected the minor allele frequency for each single nucleotide polymorphisms tested. Before administration of exogenous hormones, increasing number of G alleles at rs9282861 was associated with earlier age at menopause, lower frequency of night sweats, and less severe insomnia. Variability in onset of menopause and symptoms before initiation of hormone therapy is partly due to SULT1A1 variation. | Influence of SULT1A1 genetic variation on age at menopause, estrogen levels, and response to hormone therapy in recently postmenopausal white women.
Moyer AM, de Andrade M, Weinshilboum RM, Miller VM., Free PMC Article | 02/17/2018 |
| SULT1A1 copy number variation was negatively correlated with estrone-sulfate to estrone ratio predominantly in males (E1S/E1; p=0.03, r=-0.21) and may be associated with increased risk for common allergies. | Relationship of SULT1A1 copy number variation with estrogen metabolism and human health.
Liu J, Zhao R, Ye Z, Frey AJ, Schriver ER, Snyder NW, Hebbring SJ., Free PMC Article | 11/18/2017 |
| This study demonstrates that the presence of His allele and Gln allele in case of SULT1A1 rs9282861 and XRCC1 rs25487, respectively, involve in lung cancer prognosis in Bangladeshi population. | Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population.
Tasnim T, Al-Mamun MMA, Nahid NA, Islam MR, Apu MNH, Bushra MU, Rabbi SNI, Nahar Z, Chowdhury JA, Ahmed MU, Islam MS, Hasnat A. | 11/18/2017 |
| We conclude from these studies that SULT1A1 is involved in the bioactivation of AA-I through the sulfonation of AL-I-NOH, contributing significantly to the toxicities of AA observed in vivo. | Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N-hydroxyaristolactam I in human cells.
Hashimoto K, Zaitseva IN, Bonala R, Attaluri S, Ozga K, Iden CR, Johnson F, Moriya M, Grollman AP, Sidorenko VS., Free PMC Article | 05/20/2017 |
| Epigallocatechin gallate (EGCG) displays high affinity and specificity for SULT1A1. The allosteric network is shown to involve 14 distinct complexes. ECGG binds both the allosteric site and, relatively weakly, the active site of SULT1A1. | Isozyme Specific Allosteric Regulation of Human Sulfotransferase 1A1.
Wang T, Cook I, Leyh TS., Free PMC Article | 05/13/2017 |
| The polymorphism of SULT1A1*2 is not associated with esophageal squamous cell carcinoma risk. | Genotypes of CYP1A1, SULT1A1 and SULT1A2 and risk of squamous cell carcinoma of esophagus: outcome of a case-control study from Kashmir, India.
Shah IA, Bhat GA, Mehta P, Lone MM, Dar NA. | 05/6/2017 |
| SULT1A1 high Copy Number Variation on high Estrogen Concentration and Tamoxifen-Associated Adverse Drug Reactions in Premenopausal Thai Breast Cancer. | Effects of SULT1A1 Copy Number Variation on Estrogen Concentration and Tamoxifen-Associated Adverse Drug Reactions in Premenopausal Thai Breast Cancer Patients: A Preliminary Study.
Charoenchokthavee W, Ayudhya DP, Sriuranpong V, Areepium N. | 01/28/2017 |
| SULT1A1 is responsible for bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol. | Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.
Sachse B, Meinl W, Sommer Y, Glatt H, Seidel A, Monien BH., Free PMC Article | 10/22/2016 |
| Cytosolic sulfotransferase 1A1 regulates HIV-1 minus-strand DNA elongation in primary human monocyte-derived macrophages. | Cytosolic sulfotransferase 1A1 regulates HIV-1 minus-strand DNA elongation in primary human monocyte-derived macrophages.
Swann J, Murry J, Young JA., Free PMC Article | 10/22/2016 |