| De novo putative loss-of-function variants in TAF4 are associated with a neuro-developmental disorder. | De novo putative loss-of-function variants in TAF4 are associated with a neuro-developmental disorder.
Janssen BDE, van den Boogaard MH, Lichtenbelt K, Seaby EG, Stals K, Ellard S, Newbury-Ecob R, Dixit A, Roht L, Pajusalu S, Õunap K, Firth HV, Buckley M, Wilson M, Roscioli T, Tidwell T, Mao R, Ennis S, Holwerda SJ, van Gassen K, van Jaarsveld RH., Free PMC Article | 12/17/2022 |
| alphaalpha-hub coregulator structure and flexibility determine transcription factor binding and selection in regulatory interactomes. | αα-hub coregulator structure and flexibility determine transcription factor binding and selection in regulatory interactomes.
Friis Theisen F, Salladini E, Davidsen R, Jo Rasmussen C, Staby L, Kragelund BB, Skriver K., Free PMC Article | 07/2/2022 |
| Targeted splicing of hTAF4-TAFH coordinates AS of other TFIID subunits, underscoring the role of TAF4 in synchronised changes of Pol II complex composition essential for efficient cellular reprogramming. | Targeted alternative splicing of TAF4: a new strategy for cell reprogramming.
Kazantseva J, Sadam H, Neuman T, Palm K., Free PMC Article | 04/28/2018 |
| Identification of heteromolecular binding sites in transcription factors Sp1 and TAF4 using high-resolution nuclear magnetic resonance spectroscopy has been reported. | Identification of heteromolecular binding sites in transcription factors Sp1 and TAF4 using high-resolution nuclear magnetic resonance spectroscopy.
Hibino E, Inoue R, Sugiyama M, Kuwahara J, Matsuzaki K, Hoshino M., Free PMC Article | 11/4/2017 |
| Data suggest that many TATA-box-containing promoters contain a TFIIA recognition element (IIARE) that activates transcription by increasing the recruitment of RNA polymerase II, TFIIA (TF2A1/TF2A2 subunits), TAF4, and P300. (TAF4 = TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1; P300 = E1A binding protein p300) | A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.
Wang J, Zhao S, He W, Wei Y, Zhang Y, Pegg H, Shore P, Roberts SGE, Deng W., Free PMC Article | 08/5/2017 |
| the two Q-domains of Sp1 and four Q-domains of TAF4 were disordered under physiological conditions. | Interaction between intrinsically disordered regions in transcription factors Sp1 and TAF4.
Hibino E, Inoue R, Sugiyama M, Kuwahara J, Matsuzaki K, Hoshino M., Free PMC Article | 07/15/2017 |
| Inactivation of hTAF4-TAFH domain accelerates differentiation of human neural progenitor cells. | TAF4 controls differentiation of human neural progenitor cells through hTAF4-TAFH activity.
Kazantseva J, Tints K, Neuman T, Palm K. | 09/12/2015 |
| TAF4 isoforms generated by the alternative splicing participate in the conversion of the cellular transcriptional programs from the maintenance of stem cell state to differentiation | Alternative splicing targeting the hTAF4-TAFH domain of TAF4 represses proliferation and accelerates chondrogenic differentiation of human mesenchymal stem cells.
Kazantseva J, Kivil A, Tints K, Kazantseva A, Neuman T, Palm K., Free PMC Article | 06/28/2014 |
| These interactions are important to the transcriptional activation of these genes by Rta since introducing TAF4 shRNA substantially reduces the ability of Rta to activate these promoters | Role of TAF4 in transcriptional activation by Rta of Epstein-Barr Virus.
Yang YC, Chang LK., Free PMC Article | 07/20/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesAssociation of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. | 12/2/2009 |
| Findings suggest that DNA binding by TAF4/4b-TAF12 facilitates the association of TFIID with the core promoter of a subset of genes. | TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes.
Gazit K, Moshonov S, Elfakess R, Sharon M, Mengus G, Davidson I, Dikstein R., Free PMC Article | 01/21/2010 |
| TAF4b incorporation into TFIID induces an open conformation at the lobe involved in TFIIA & putative activator interactions, correlating with differential activator-dependent transcription & promoter recognition by 4b/4-IID. | Structural changes in TAF4b-TFIID correlate with promoter selectivity.
Liu WL, Coleman RA, Grob P, King DS, Florens L, Washburn MP, Geles KG, Yang JL, Ramey V, Nogales E, Tjian R., Free PMC Article | 01/21/2010 |
| Data present the crystal structure of a complex formed by the interacting domains from two subunits of the general transcription factor TFIID, the human TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20). | Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20).
Werten S, Mitschler A, Romier C, Gangloff YG, Thuault S, Davidson I, Moras D. | 01/21/2010 |
| trans-activation of promoters by simian virus 40 small t-antigen may depend on a consensus TATA motif and such promoters recruit the general transcription factor hTAF(II)130/135 | A role of the TATA box and the general co-activator hTAF(II)130/135 in promoter-specific trans-activation by simian virus 40 small t antigen.
Johannessen M, Olsen PA, Sørensen R, Johansen B, Seternes OM, Moens U. | 01/21/2010 |
| huntingtin interacts with Sp1 and TAFII130; transcriptional activity of SP1 and TAFII130 disrupted in early Huntingtin's Disease | Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.
Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, Hersch SM, Mouradian MM, Young AB, Tanese N, Krainc D. | 01/21/2010 |