| Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen. | Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen.
Lucero D, Dikilitas O, Mendelson MM, Aligabi Z, Islam P, Neufeld EB, Bansal AT, Freeman LA, Vaisman B, Tang J, Combs CA, Li Y, Voros S, Kullo IJ, Remaley AT., Free PMC Article | 08/29/2024 |
| LZTS3/TAGLN Suppresses Cancer Progression in Human Colorectal Adenocarcinoma Through Regulating Cell Proliferation, Migration, and Actin Cytoskeleton. | LZTS3/TAGLN Suppresses Cancer Progression in Human Colorectal Adenocarcinoma Through Regulating Cell Proliferation, Migration, and Actin Cytoskeleton.
Gu X, Chen S, Wang Z, Bu Q, An S. | 02/15/2024 |
| Loss of prolyl hydroxylase 1 and 2 in SM22alpha-expressing cells prevents Hypoxia-Induced pulmonary hypertension. | Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension.
Barnes EA, Ito R, Che X, Alvira CM, Cornfield DN., | 11/18/2023 |
| Hypoxia-Inducible Factor-1alpha in SM22alpha-Expressing Cells Modulates Alveolarization. | Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization.
Barnes EA, Knutsen C, Kindt A, Che X, Ying L, Adams E, Gonzalez E, Oak P, Hilgendorff A, Alvira CM, Cornfield DN., Free PMC Article | 10/11/2023 |
| Transgelin promotes ferroptosis to inhibit the malignant progression of esophageal squamous cell carcinoma. | Transgelin promotes ferroptosis to inhibit the malignant progression of esophageal squamous cell carcinoma.
Chen Q, Zhang L, Wan C, Yang B, Kong X, Xu X, Gu Y, Wang C, Liu X, Ding Q, Zhu L, Li Y, Wang B, Zhong W., Free PMC Article | 05/25/2023 |
| RNA-sequencing of human aortic valves identifies that miR-629-3p and TAGLN miRNA-mRNA pair involving in calcified aortic valve disease. | RNA-sequencing of human aortic valves identifies that miR-629-3p and TAGLN miRNA-mRNA pair involving in calcified aortic valve disease.
Wang C, Han J, Liu M, Huang Y, Zhou T, Jiang N, Hui H, Xu K. | 12/3/2022 |
| TAGLN Is Downregulated by TRAF6-Mediated Proteasomal Degradation in Prostate Cancer Cells. | TAGLN Is Downregulated by TRAF6-Mediated Proteasomal Degradation in Prostate Cancer Cells.
Wen F, Sun X, Sun C, Dong Z, Jia G, Bao W, Yu H, Yang C. | 01/29/2022 |
| TAGLN mediated stiffness-regulated ovarian cancer progression via RhoA/ROCK pathway. | TAGLN mediated stiffness-regulated ovarian cancer progression via RhoA/ROCK pathway.
Wei X, Lou H, Zhou D, Jia Y, Li H, Huang Q, Ma J, Yang Z, Sun C, Meng Y, Xu S, Yang X, Li X, Ji T, Guo Z, Gao Q., Free PMC Article | 01/22/2022 |
| Identification of targets of JS-K against HBV-positive human hepatocellular carcinoma HepG2.2.15 cells with iTRAQ proteomics. | Identification of targets of JS-K against HBV-positive human hepatocellular carcinoma HepG2.2.15 cells with iTRAQ proteomics.
Liu Z, Xu Y, Zhang W, Gao X, Luo G, Song H, Liu J, Wang H., Free PMC Article | 10/30/2021 |
| The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis. | The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis.
Tsuji-Tamura K, Morino-Koga S, Suzuki S, Ogawa M. | 10/30/2021 |
| m(6)A demethylase ALKBH5 suppresses proliferation and migration of enteric neural crest cells by regulating TAGLN in Hirschsprung's disease. | m(6)A demethylase ALKBH5 suppresses proliferation and migration of enteric neural crest cells by regulating TAGLN in Hirschsprung's disease.
Wang B, Fang X, Sun X, Du C, Zhou L, Lv X, Li Y, Li H, Tang W. | 07/10/2021 |
| Cartilage Oligomeric Matrix Protein promotes epithelial-mesenchymal transition by interacting with Transgelin in Colorectal Cancer. | Cartilage Oligomeric Matrix Protein promotes epithelial-mesenchymal transition by interacting with Transgelin in Colorectal Cancer.
Zhong W, Hou H, Liu T, Su S, Xi X, Liao Y, Xie R, Jin G, Liu X, Zhu L, Zhang H, Song X, Yang C, Sun T, Cao H, Wang B., Free PMC Article | 05/22/2021 |
| Transgelin Silencing Induces Different Processes in Different Breast Cancer Cell Lines. | Transgelin Silencing Induces Different Processes in Different Breast Cancer Cell Lines.
Dvorakova M, Lapcik P, Bouchalova P, Bouchal P. | 04/13/2021 |
| Transgelin is a poor prognostic factor associated with advanced colorectal cancer (CRC) stage promoting tumor growth and migration in a TGFbeta-dependent manner. | Transgelin is a poor prognostic factor associated with advanced colorectal cancer (CRC) stage promoting tumor growth and migration in a TGFβ-dependent manner.
Elsafadi M, Manikandan M, Almalki S, Mahmood A, Shinwari T, Vishnubalaji R, Mobarak M, Alfayez M, Aldahmash A, Kassem M, Alajez NM., Free PMC Article | 03/13/2021 |
| Functional loss of TAGLN inhibits tumor growth and increases chemosensitivity of non-small cell lung cancer. | Functional loss of TAGLN inhibits tumor growth and increases chemosensitivity of non-small cell lung cancer.
Fu J, Wang X, Yue Q. | 02/13/2021 |
| Results indicate that TAGLN is a p53 and PTEN-upregulated gene, expressing higher levels in normal bladder epithelial cells than in carcinoma cells. Further, TAGLN inhibited cell proliferation and invasion in vitro and blocked tumorigenesis in vivo. Collectively, it can be concluded that TAGLN is an antitumor gene in the human bladder. | Transgelin, a p53 and PTEN-Upregulated Gene, Inhibits the Cell Proliferation and Invasion of Human Bladder Carcinoma Cells in Vitro and in Vivo.
Tsui KH, Lin YH, Chang KS, Hou CP, Chen PJ, Feng TH, Juang HH., Free PMC Article | 02/15/2020 |
| SM22alpha reduction in abdominal aortic aneurysms (AAAs) because of the SM22alpha promoter hypermethylation accelerates AAA formation through the reactive oxygen species/NF-kappaB pathway. | SM22α (Smooth Muscle 22α) Prevents Aortic Aneurysm Formation by Inhibiting Smooth Muscle Cell Phenotypic Switching Through Suppressing Reactive Oxygen Species/NF-κB (Nuclear Factor-κB).
Zhong L, He X, Si X, Wang H, Li B, Hu Y, Li M, Chen X, Liao W, Liao Y, Bin J. | 12/7/2019 |
| SM22 is released into the circulation upon severe ischemia of the intestinal muscle layers. Patients with transmural intestinal ischemia had significantly higher plasma SM22 levels than patients with only ischemic mucosal injury, other acute abdominal diseases, or healthy controls. | SM22 a Plasma Biomarker for Human Transmural Intestinal Ischemia.
Schellekens DHSM, Reisinger KW, Lenaerts K, Hadfoune M, Olde Damink SW, Buurman WA, Dejong CHC, Derikx JPM. | 09/7/2019 |
| SM22 plays a role in regulating the transitions and morphological appearance of bacterially generated actin-rich structures during infections. | SM22 is required for the maintenance of actin-rich structures generated during bacterial infections.
Chua MD, Hipolito KJ, Singerr OB, Solway J, Guttman JA. | 06/1/2019 |
| transgelin-1 interacts with actin stress fibers and podosomes in smooth muscle cells via its type-3 CH-domain, while CLIK23 is dispensable for the binding to the actin structures | Transgelin-1 (SM22α) interacts with actin stress fibers and podosomes in smooth muscle cells without using its actin binding site.
Matsui TS, Ishikawa A, Deguchi S. | 05/18/2019 |
| High expression level of TAGLN is associated with prostate cancer. | Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes.
Webber JP, Spary LK, Mason MD, Tabi Z, Brewis IA, Clayton A., Free PMC Article | 01/20/2018 |
| this study identified potential biochemical players involved in distant recurrence and indicates that R-Ras and Transgelin are potential post-surgical prognostic biomarkers for Stage III colorectal cancer | Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.
Xu L, Gao Y, Chen Y, Xiao Y, He Q, Qiu H, Ge W., Free PMC Article | 01/20/2018 |
| During transition from the pluripotent stage towards the neural developmental stage, TAGLN is differentially expressed in bipolar patient derived cells compared to control derived cells. | Early onset of inflammation during ontogeny of bipolar disorder: the NLRP2 inflammasome gene distinctly differentiates between patients and healthy controls in the transition between iPS cell and neural stem cell stages.
Vizlin-Hodzic D, Zhai Q, Illes S, Södersten K, Truvé K, Parris TZ, Sobhan PK, Salmela S, Kosalai ST, Kanduri C, Strandberg J, Seth H, Bontell TO, Hanse E, Ågren H, Funa K., Free PMC Article | 11/18/2017 |
| Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix. | Mechanoregulation of SM22α/Transgelin.
Liu R, Hossain MM, Chen X, Jin JP. | 10/28/2017 |
| transgelin (TAGLN), a transforming growth factor beta (TGFbeta)-inducible gene, was identified as an upregulated gene during in vitro osteoblastic and adipocytic differentiation of human bone marrow-derived stromal (skeletal) stem cells | Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization.
Elsafadi M, Manikandan M, Dawud RA, Alajez NM, Hamam R, Alfayez M, Kassem M, Aldahmash A, Mahmood A., Free PMC Article | 09/30/2017 |