| TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers. | TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers.
Damhofer H, Tatar T, Southgate B, Scarneo S, Agger K, Shlyueva D, Uhrbom L, Morrison GM, Hughes PF, Haystead T, Pollard SM, Helin K., Free PMC Article | 05/2/2024 |
| The Effects and Mechanisms of Xanthones in Alzheimer's Disease: A Systematic Review. | The Effects and Mechanisms of Xanthones in Alzheimer's Disease: A Systematic Review.
Pang LW, Hamzah S, Tan SLJ, Mah SH, Yow HY. | 11/27/2023 |
| USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1. | USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1.
Zhang H, Han Y, Xiao W, Gao Y, Sui Z, Ren P, Meng F, Tang P, Yu Z., Free PMC Article | 11/14/2023 |
| Association of XIST/miRNA155/Gab2/TAK1 cascade with the pathogenesis of anti-phospholipid syndrome and its effect on cell adhesion molecules and inflammatory mediators. | Association of XIST/miRNA155/Gab2/TAK1 cascade with the pathogenesis of anti-phospholipid syndrome and its effect on cell adhesion molecules and inflammatory mediators.
Abd-Elmawla MA, Elsabagh YA, Aborehab NM., Free PMC Article | 11/7/2023 |
| Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis. | Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis.
Bale S, Verma P, Yalavarthi B, Scarneo SA, Hughes P, Amin MA, Tsou PS, Khanna D, Haystead TA, Bhattacharyya S, Varga J., Free PMC Article | 07/25/2023 |
| SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner. | SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner.
Qian Q, Hu F, Yu W, Leng D, Li Y, Shi H, Deng D, Ding K, Liang C, Liu J., Free PMC Article | 04/10/2023 |
| Emerging role of TAK1 in the regulation of skeletal muscle mass. | Emerging role of TAK1 in the regulation of skeletal muscle mass.
Roy A, Narkar VA, Kumar A., Free PMC Article | 03/22/2023 |
| MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure. | MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure.
Saxena V, Arregui S, Kamocka MM, Hains DS, Schwaderer A., Free PMC Article | 11/26/2022 |
| Enhanced expression of mRNA for transforming growth factor beta activated kinase 1 in CD34+ cells of the bone marrow in rheumatoid arthritis. | Enhanced expression of mRNA for transforming growth factor β activated kinase 1 in CD34+ cells of the bone marrow in rheumatoid arthritis.
Hirohata S, Nagai T, Tomita T. | 11/12/2022 |
| TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells. | TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells.
Rodrigues M, Petrova T, Tibbs B, Arthur JSC, Cohen P., Free PMC Article | 10/15/2022 |
| MicroRNA-449c-5p alleviates lipopolysaccharide-induced HUVECs injury via inhibiting the activation NF-kappab signaling pathway by TAK1. | MicroRNA-449c-5p alleviates lipopolysaccharide-induced HUVECs injury via inhibiting the activation NF-κb signaling pathway by TAK1.
Fu Q, Yu W, Fu S, Xu Z, Zhang S. | 05/21/2022 |
| TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance. | TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.
Xia S, Ji L, Tao L, Pan Y, Lin Z, Wan Z, Pan H, Zhao J, Cai L, Xu J, Cai X., Free PMC Article | 03/12/2022 |
| SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes. | SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes.
Lieu YK, Liu Z, Ali AM, Wei X, Penson A, Zhang J, An X, Rabadan R, Raza A, Manley JL, Mukherjee S., Free PMC Article | 02/26/2022 |
| Targeted inhibition of TAK1 abrogates TGFbeta1 non-canonical signaling axis, NFkappaB/Smad7 inhibiting human endometriotic cells proliferation and inducing cell death involving autophagy. | Targeted inhibition of TAK1 abrogates TGFβ1 non-canonical signaling axis, NFκB/Smad7 inhibiting human endometriotic cells proliferation and inducing cell death involving autophagy.
Kaushal JB, Shukla V, Sankhwar P, Jha RK, Dwivedi A. | 02/19/2022 |
| MAP3K7 Loss Drives Enhanced Androgen Signaling and Independently Confers Risk of Recurrence in Prostate Cancer with Joint Loss of CHD1. | MAP3K7 Loss Drives Enhanced Androgen Signaling and Independently Confers Risk of Recurrence in Prostate Cancer with Joint Loss of CHD1.
Jillson LK, Rider LC, Rodrigues LU, Romero L, Karimpour-Fard A, Nieto C, Gillette C, Torkko K, Danis E, Smith EE, Nolley R, Peehl DM, Lucia MS, Costello JC, Cramer SD., Free PMC Article | 01/29/2022 |
| Tumor resistance to radiotherapy is triggered by an ATM/TAK1-dependent-increased expression of the cellular prion protein. | Tumor resistance to radiotherapy is triggered by an ATM/TAK1-dependent-increased expression of the cellular prion protein.
Bernardino-Sgherri J, Siberchicot C, Auvré F, Busso D, Brocas C, El Masri G, Lioutsko A, Ferri F, Radicella JP, Romeo PH, Bravard A. | 01/15/2022 |
| MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression. | MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression.
Huang Z, Tang B, Yang Y, Yang Z, Shi L, Bai Y, Yan B, Karnes RJ, Zhang J, Jimenez R, Wang L, Wei Q, Yang J, Xu W, Jia Z, Huang H. | 01/8/2022 |
| MicroRNA129 plays a protective role in sepsisinduced acute lung injury through the suppression of pulmonary inflammation via the modulation of the TAK1/NFkappaB pathway. | MicroRNA‑129 plays a protective role in sepsis‑induced acute lung injury through the suppression of pulmonary inflammation via the modulation of the TAK1/NF‑κB pathway.
Yao W, Xu L, Jia X, Li S, Wei L., Free PMC Article | 12/11/2021 |
| TRIM31 promotes apoptosis via TAK1-mediated activation of NF-kappaB signaling in sepsis-induced myocardial dysfunction. | TRIM31 promotes apoptosis via TAK1-mediated activation of NF-κB signaling in sepsis-induced myocardial dysfunction.
Yang X, Sun J, Sun F, Yao Y, Tian T, Zhou J, Shen W, Lu M, Lei M., Free PMC Article | 12/11/2021 |
| USP1-WDR48 deubiquitinase complex enhances TGF-beta induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1. | USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1.
Han D, Wang L, Chen B, Zhao W, Liang Y, Li Y, Zhang H, Liu Y, Wang X, Chen T, Li C, Song X, Luo D, Li Z, Yang Q., Free PMC Article | 12/4/2021 |
| Plasma IL8 Is a Biomarker for TAK1 Activation and Predicts Resistance to Nanoliposomal Irinotecan in Patients with Gemcitabine-Refractory Pancreatic Cancer. | Plasma IL8 Is a Biomarker for TAK1 Activation and Predicts Resistance to Nanoliposomal Irinotecan in Patients with Gemcitabine-Refractory Pancreatic Cancer.
Merz V, Zecchetto C, Santoro R, Simionato F, Sabbadini F, Mangiameli D, Piro G, Cavaliere A, Deiana M, Valenti MT, Bazan D, Fedele V, Lonardi S, Melisi D. | 11/27/2021 |
| Characterization of the aberrant splicing of MAP3K7 induced by cancer-associated SF3B1 mutation. | Characterization of the aberrant splicing of MAP3K7 induced by cancer-associated SF3B1 mutation.
Li Z, Zhao B, Shi Y, Liang Y, Qian R, Wan Y. | 10/2/2021 |
| TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-kappaB pathways. | TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways.
Zhou Y, Tao T, Liu G, Gao X, Gao Y, Zhuang Z, Lu Y, Wang H, Li W, Wu L, Zhang D, Hang C., Free PMC Article | 10/2/2021 |
| DGKzeta depletion attenuates HIF-1alpha induction and SIRT1 expression, but enhances TAK1-mediated AMPKalpha phosphorylation under hypoxia. | DGKζ depletion attenuates HIF-1α induction and SIRT1 expression, but enhances TAK1-mediated AMPKα phosphorylation under hypoxia.
Akimoto R, Tanaka T, Nakano T, Hozumi Y, Kawamae K, Goto K. | 08/7/2021 |
| TAK1 is involved in sodium L-lactate-stimulated p38 signaling and promotes apoptosis. | TAK1 is involved in sodium L-lactate-stimulated p38 signaling and promotes apoptosis.
Da Q, Yan Z, Li Z, Han Z, Ren M, Huang L, Zhang X, Liu J, Wang T. | 07/24/2021 |