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    TCF7L2 transcription factor 7 like 2 [ Homo sapiens (human) ]

    Gene ID: 6934, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans.

    The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans.
    Zeini M, Laurenti MC, Egan AM, Muthusamy K, Ramar A, Vella E, Bailey KR, Cobelli C, Dalla Man C, Vella A.,

    10/1/2024
    Haplotype-based association study of TCF7L2 gene variants with the development of diabetic retinopathy in an Iranian population.

    Haplotype-based association study of TCF7L2 gene variants with the development of diabetic retinopathy in an Iranian population.
    Alidoust L, Sharafshah A, Keshavarz P.

    09/16/2024
    Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway.

    Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway.
    Tang L, Xu S, Wei R, Fan G, Zhou J, Wei X, Xu X., Free PMC Article

    08/30/2024
    Astrocytic beta-catenin signaling via TCF7L2 regulates synapse development and social behavior.

    Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior.
    Szewczyk LM, Lipiec MA, Liszewska E, Meyza K, Urban-Ciecko J, Kondrakiewicz L, Goncerzewicz A, Rafalko K, Krawczyk TG, Bogaj K, Vainchtein ID, Nakao-Inoue H, Puscian A, Knapska E, Sanders SJ, Jan Nowakowski T, Molofsky AV, Wisniewska MB., Free PMC Article

    06/5/2024
    TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study.

    TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study.
    Cruciat G, Florian AR, Chaikh-Sulaiman MS, Staicu A, Caracostea GV, Procopciuc LM, Stamatian F, Muresan D., Free PMC Article

    05/13/2024
    Association of Polymorphic Variants of TCF7L2 and PPARG Genes with Metabolic Markers in Patients with Early Disorders of Carbohydrate Metabolism.

    Association of Polymorphic Variants of TCF7L2 and PPARG Genes with Metabolic Markers in Patients with Early Disorders of Carbohydrate Metabolism.
    Isakova DN, Kolomeichuk SN, Petrova YA, Lyapina MV, Troshina IA, Voronin KA, Petrov IM.

    03/31/2024
    MiR-27a-3p exacerbates cell migration and invasion in right-sided/left-sided colorectal cancer by targeting TGFBR2/TCF7L2.

    MiR-27a-3p exacerbates cell migration and invasion in right-sided/left-sided colorectal cancer by targeting TGFBR2/TCF7L2.
    Bi L, Zhou Y, Zhang Y, Zhang X.

    03/21/2024
    Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes.

    Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes.
    Al Hageh C, O'Sullivan S, Platt DE, Henschel A, Chacar S, Gauguier D, Abchee A, Alefishat E, Nader M, Zalloua PA.

    02/16/2024
    Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis.

    Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis.
    He J, Zhang M, Ren J, Jiang X., Free PMC Article

    01/17/2024
    Association between Transcription Factor 7-Like 2 C/T Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis.

    Association between Transcription Factor 7-Like 2 C/T Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis.
    Zhang Y, Pan GP, Cai JW, Niu YM, Xie LC.

    01/11/2024
    TCF7L2 (rs7903146) But Not CDKAL1 (rs7754840) Gene Polymorphisms Increase the Risk of New-Onset Diabetes After Kidney Transplant.

    TCF7L2 (rs7903146) But Not CDKAL1 (rs7754840) Gene Polymorphisms Increase the Risk of New-Onset Diabetes After Kidney Transplant.
    Helvaci Ö, Korucu B, Yeter HH, Gönen S, Cavnar Helvaci B, Sanisoğlu Y, Bali M, Güz G.

    01/3/2024
    BRD4-binding enhancer promotes CRC progression by interacting with YY1 to activate the Wnt pathway through upregulation of TCF7L2.

    BRD4-binding enhancer promotes CRC progression by interacting with YY1 to activate the Wnt pathway through upregulation of TCF7L2.
    Duan B, Zhou X, Zhang X, Qiu F, Zhang S, Chen Y, Yang J, Wang J, Tan W.

    12/6/2023
    Association of transcription factor 7-like 2 rs12255372 polymorphism with susceptibility of type 2 diabetes mellitus in Bangladeshi population.

    Association of transcription factor 7-like 2 rs12255372 polymorphism with susceptibility of type 2 diabetes mellitus in Bangladeshi population.
    Barman N, Atiqul Haque M, Firoz M, Abdullah Yusuf M, Islam ABMMK.

    10/26/2023
    Novel linkage and association of TCF7L2 variants with PCOS in Italian families.

    Novel linkage and association of TCF7L2 variants with PCOS in Italian families.
    Amin M, Del Bosque-Plata L, Gragnoli C.

    08/25/2023
    Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations.

    Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations.
    Srinivasan S, Liju S, Sathish N, Siddiqui MK, Anjana RM, Pearson ER, Doney ASF, Mohan V, Radha V, Palmer CNA., Free PMC Article

    07/31/2023
    rs7903146 mutation of Type 2 diabetes mellitus-related gene TCF7L2 is not associated with polycystic ovary syndrome in a cohort of Turkey.

    rs7903146 mutation of Type 2 diabetes mellitus-related gene TCF7L2 is not associated with polycystic ovary syndrome in a cohort of Turkey.
    Taşkin E, Eroğlu S.

    06/15/2023
    Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar.

    Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar.
    Phu S, Thida A, Maung KK, Chit TT., Free PMC Article

    05/30/2023
    TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population.

    TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population.
    Mitroi AF, Leopa N, Dumitru E, Dumitru A, Tocia C, Popescu I, Mitroi A, Popescu RC., Free PMC Article

    02/22/2023
    Novel TCF7L2 familial linkage and association with Type 2 diabetes, depression, and their comorbidity.

    Novel TCF7L2 familial linkage and association with Type 2 diabetes, depression, and their comorbidity.
    Del Bosque-Plata L, Amin M, Wu R, Postolache TT, Gragnoli C.

    02/10/2023
    Association between TCF7L2 polymorphism and type 2 diabetes mellitus susceptibility: a case-control study among the Bangladeshi population.

    Association between TCF7L2 polymorphism and type 2 diabetes mellitus susceptibility: a case-control study among the Bangladeshi population.
    Salauddin A, Chakma K, Hasan MM, Akter F, Chowdhury NA, Chowdhury SR, Mannan A.

    02/4/2023
    Transcriptional activity mediated by beta-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines.

    Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines.
    Fröhlich J, Rose K, Hecht A., Free PMC Article

    01/21/2023
    Transcription factor 7-like 2 single nucleotide polymorphisms rs290487 and rs290481 are associated with dyslipidemia in the Balinese population.

    Transcription factor 7-like 2 single nucleotide polymorphisms rs290487 and rs290481 are associated with dyslipidemia in the Balinese population.
    Limardi PC, Oktavianthi S, Priliani L, Lestari R, Saraswati MR, Suastika K, Malik SG., Free PMC Article

    01/14/2023
    Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants.

    Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants.
    Redondo MJ, Richardson SJ, Perry D, Minard CG, Carr ALJ, Brusko T, Kusmartseva I, Pugliese A, Atkinson MA., Free PMC Article

    12/17/2022
    TCF7L2 gene associated postprandial triglyceride dysmetabolism- a novel mechanism for diabetes risk among Asian Indians.

    TCF7L2 gene associated postprandial triglyceride dysmetabolism- a novel mechanism for diabetes risk among Asian Indians.
    Madhu SV, Mishra BK, Mannar V, Aslam M, Banerjee B, Agrawal V., Free PMC Article

    10/29/2022
    The positive regulatory loop of TCF4N/p65 promotes glioblastoma tumourigenesis and chemosensitivity.

    The positive regulatory loop of TCF4N/p65 promotes glioblastoma tumourigenesis and chemosensitivity.
    Hu Y, Zhang B, Lu P, Wang J, Chen C, Yin Y, Wan Q, Wang J, Jiao J, Fang X, Pu Z, Gong L, Ji L, Zhu L, Zhang R, Zhang J, Yang X, Wang Q, Huang Z, Zou J., Free PMC Article

    10/8/2022
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